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Search life-sciences literature (45,105,671 articles, preprints and more)

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Differences in the pathological, transcriptomic, and prognostic implications of lymphoid structures between primary and metastatic cutaneous melanomas.
Karapetyan L, Li A, Vargas De Stefano D, Abushukair HM, Al-Bzour AN, Knight A, Layding C, Wang H, Xu J, Yao J, Song X, Joy M, Nguyen J, Moran-Segura C, Bruno S, Sander C, Messina J, Mule JJ, Storkus WJ, Kirkwood JM
J Immunother Cancer, 12(11):e009231, 12 Nov 2024
Cited by: 0 articles | PMID: 39537211
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Neoadjuvant vidutolimod and nivolumab in high-risk resectable melanoma: A prospective phase II trial.
Davar D, Morrison RM, Dzutsev AK, Karunamurthy A, Chauvin JM, Amatore F, Deutsch JS, Das Neves RX, Rodrigues RR, McCulloch JA, Wang H, Hartman DJ, Badger JH, Fernandes MR, Bai Y, Sun J, Cole AM, Aggarwal P, Fang JR, [...] Zarour HM
Cancer Cell, 42(11):1898-1918.e12, 31 Oct 2024
Cited by: 0 articles | PMID: 39486411
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NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs.
Dong B, Obermajer N, Tsuji T, Matsuzaki J, Bonura CM, Sander C, Withers H, Long MD, Chavel C, Olejniczak SH, Minderman H, Kirkwood JM, Edwards RP, Storkus WJ, Romero P, Kalinski P
Cancer Immunol Res, 12(10):1421-1437, 01 Oct 2024
Cited by: 0 articles | PMID: 38949179
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Evaluation and Surgical Management of Pediatric Cutaneous Melanoma and Atypical Spitz and Non-Spitz Melanocytic Tumors (Melanocytomas): A Report From Children's Oncology Group.
Sargen MR, Barnhill RL, Elder DE, Swetter SM, Prieto VG, Ko JS, Bahrami A, Gerami P, Karunamurthy A, Pappo AS, Schuchter LM, LeBoit PE, Yeh I, Kirkwood JM, Jen M, Dunkel IJ, Durham MM, Christison-Lagay ER, Austin MT, [...] Seynnaeve B
J Clin Oncol, JCO2401154, 04 Oct 2024
Cited by: 0 articles | PMID: 39365959
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Treatment outcomes following partial shave biopsy of atypical and malignant melanocytic tumors in pediatric patients.
Arjunan A, Wardrop M, Malek MM, Davit AJ, Sargen MR, Kirkwood JM, Demanelis K, Seynnaeve BKN
Melanoma Res, 34(6):544-548, 05 Sep 2024
Cited by: 0 articles | PMID: 39235826
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Feasibility of a prospective pediatric melanocytic tumor clinical trial: A report of multidisciplinary clinician survey data from the Children's Oncology Group Rare Tumor Committee.
Mitchell SG, Christison-Lagay E, Aldrink J, Sargen MR, Laetsch TW, Austin M, Jen M, Gartrell R, Karunamurthy A, Kirkwood JM, Pappo AS, Seynnaeve BKN
Pediatr Blood Cancer, 71(12):e31312, 09 Sep 2024
Cited by: 0 articles | PMID: 39252525
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Assessing clonal changes in T cells over time following immunotherapy is a breeze with Cyclone.
Cillo AR, Kirkwood JM
Cancer Cell, 42(9):1491-1493, 01 Sep 2024
Cited by: 0 articles | PMID: 39255774
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Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8⁺ T cells to promote antitumor immunity.
Cillo AR, Cardello C, Shan F, Karapetyan L, Kunning S, Sander C, Rush E, Karunamurthy A, Massa RC, Rohatgi A, Workman CJ, Kirkwood JM, Bruno TC, Vignali DAA
Cell, 187(16):4373-4388.e15, 01 Aug 2024
Cited by: 4 articles | PMID: 39121849
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LAG-3 and PD-1 synergize on CD8<sup>+</sup> T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity.
Andrews LP, Butler SC, Cui J, Cillo AR, Cardello C, Liu C, Brunazzi EA, Baessler A, Xie B, Kunning SR, Ngiow SF, Huang YJ, Manne S, Sharpe AH, Delgoffe GM, Wherry EJ, Kirkwood JM, Bruno TC, Workman CJ, Vignali DAA
Cell, 187(16):4355-4372.e22, 01 Aug 2024
Cited by: 4 articles | PMID: 39121848
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Automated Quantitative CD8+ Tumor-Infiltrating Lymphocytes and Tumor Mutation Burden as Independent Biomarkers in Melanoma Patients Receiving Front-Line Anti-PD-1 Immunotherapy.
Fortman D, Karunamurthy A, Hartman D, Wang H, Seigh L, Abukhiran I, Najjar YG, Pantanowitz L, Zarour HM, Kirkwood JM, Davar D
Oncologist, 29(7):619-628, 01 Jul 2024
Cited by: 1 article | PMID: 38655867 | PMCID: PMC11224974
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Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma.
Long GV, Hauschild A, Santinami M, Kirkwood JM, Atkinson V, Mandala M, Merelli B, Sileni VC, Nyakas M, Haydon A, Dutriaux C, Robert C, Mortier L, Schachter J, Schadendorf D, Lesimple T, Plummer R, Larkin J, Tan M, [...] Dummer R
N Engl J Med, 391(18):1709-1720, 19 Jun 2024
Cited by: 1 article | PMID: 38899716
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GZ17-6.02 kills PDX isolates of uveal melanoma.
Booth L, Roberts JL, Spasojevic I, Baker KC, Poklepovic A, West C, Kirkwood JM, Dent P
Oncotarget, 15:328-344, 17 May 2024
Cited by: 0 articles | PMID: 38758815 | PMCID: PMC11101052
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Neoadjuvant Dual Checkpoint Inhibitors vs Anti-PD1 Therapy in High-Risk Resectable Melanoma: A Pooled Analysis.
Mangla A, Lee C, Mirsky MM, Wang M, Rothermel LD, Hoehn R, Bordeaux JS, Carroll BT, Theuner J, Li S, Fu P, Kirkwood JM
JAMA Oncol, 10(5):612-620, 01 May 2024
Cited by: 3 articles | PMID: 38546551 | PMCID: PMC10979364
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Radiomic analysis of patient and inter-organ heterogeneity in response to immunotherapies and BRAF targeted therapy in metastatic melanoma
Tompkins A, Gray ZN, Dadey RE, Zenkin S, Batavani N, Newman S, Amouzegar A, Ak M, Ak N, Pak TY, Peddagangireddy V, Mamindla P, Behr S, Goodman A, Ploucha DL, Kirkwood JM, Zarour HM, Najjar YG, Davar D, [...] Bao R
medRxiv, 27 Apr 2024
Cited by: 0 articles | PPR: PPR844278
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Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma: Outcomes in histopathologic subgroups from the randomized, double-blind, phase 3 KEYNOTE-716 trial.
Schadendorf D, Luke JJ, Ascierto PA, Long GV, Rutkowski P, Khattak A, Del Vecchio M, de la Cruz-Merino L, Mackiewicz J, Sileni VC, Kirkwood JM, Robert C, Grob JJ, Dummer R, Carlino MS, Zhao Y, Kalabis M, Krepler C, Eggermont A, Scolyer RA
J Immunother Cancer, 12(3):e007501, 13 Mar 2024
Cited by: 1 article | PMID: 38485189 | PMCID: PMC10941196
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Pembrolizumab Versus Placebo as Adjuvant Therapy in Resected Stage IIB or IIC Melanoma: Final Analysis of Distant Metastasis-Free Survival in the Phase III KEYNOTE-716 Study.
Luke JJ, Ascierto PA, Khattak MA, de la Cruz Merino L, Del Vecchio M, Rutkowski P, Spagnolo F, Mackiewicz J, Chiarion-Sileni V, Kirkwood JM, Robert C, Grob JJ, de Galitiis F, Schadendorf D, Carlino MS, Wu XL, Fukunaga-Kalabis M, Krepler C, Eggermont AMM, Long GV
J Clin Oncol, 42(14):1619-1624, 07 Mar 2024
Cited by: 11 articles | PMID: 38452313 | PMCID: PMC11095869
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Author Correction: Adjuvant nivolumab in resected stage IIB/C melanoma: primary results from the randomized, phase 3 CheckMate 76K trial.
Kirkwood JM, Del Vecchio M, Weber J, Hoeller C, Grob JJ, Mohr P, Loquai C, Dutriaux C, Chiarion-Sileni V, Mackiewicz J, Rutkowski P, Arenberger P, Quereux G, Meniawy TM, Ascierto PA, Menzies AM, Durani P, Lobo M, Campigotto F, [...] Long GV
Nat Med, 30(3):906, 01 Mar 2024
Cited by: 0 articles | PMID: 38177857 | PMCID: PMC10957465
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Publisher Correction: Adjuvant nivolumab in resected stage IIB/C melanoma: primary results from the randomized, phase 3 CheckMate 76K trial.
Kirkwood JM, Del Vecchio M, Weber J, Hoeller C, Grob JJ, Mohr P, Loquai C, Dutriaux C, Chiarion-Sileni V, Mackiewicz J, Rutkowski P, Arenberger P, Quereux G, Meniawy TM, Ascierto PA, Menzies AM, Durani P, Lobo M, Campigotto F, [...] Long GV
Nat Med, 30(2):607, 01 Feb 2024
Cited by: 0 articles | PMID: 37923838 | PMCID: PMC10878963
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Plain language summary of the CheckMate 76K study results: nivolumab given after stage 2B/2C melanoma is removed by surgery.
Kirkwood JM, Vecchio MD, Weber J, Hoeller C, Grob JJ, Mohr P, Loquai C, Dutriaux C, Chiarion-Sileni V, Mackiewicz J, Rutkowski P, Arenberger P, Quereux G, Meniawy TM, Ascierto PA, Menzies AM, Durani P, Lobo M, Campigotto F, [...] Long GV
Future Oncol, 20(15):959-968, 23 Feb 2024
Cited by: 0 articles | PMID: 38390818
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Correction: Combination of Itacitinib or Parsaclisib with Pembrolizumab in Patients with Advanced Solid Tumors: A Phase I Study.
Munster P, Iannotti N, Cho DC, Kirkwood JM, Villaruz LC, Gibney GT, Hodi FS, Mettu NB, Jones M, Bowman J, Smith M, Lakshminarayanan M, O'Day S
Cancer Res Commun, 4(3):785, 01 Mar 2024
Cited by: 0 articles | PMID: 38477691 | PMCID: PMC10936421
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Prognostic gene expression profile testing to inform use of adjuvant therapy: A survey of melanoma experts.
Fastner S, Shen N, Hartman RI, Chu EY, Kim CC, Kirkwood JM, Grossman D
Cancer Med, 12(24):22103-22108, 14 Dec 2023
Cited by: 2 articles | PMID: 38098216 | PMCID: PMC10757117
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Combination of Itacitinib or Parsaclisib with Pembrolizumab in Patients with Advanced Solid Tumors: A Phase I Study.
Munster P, Iannotti N, Cho DC, Kirkwood JM, Villaruz LC, Gibney GT, Hodi FS, Mettu NB, Jones M, Bowman J, Smith M, Lakshminarayanan M, O'Day S
Cancer Res Commun, 3(12):2572-2584, 01 Dec 2023
Cited by: 3 articles | PMID: 38115208 | PMCID: PMC10729644
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Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma.
Hassel JC, Piperno-Neumann S, Rutkowski P, Baurain JF, Schlaak M, Butler MO, Sullivan RJ, Dummer R, Kirkwood JM, Orloff M, Sacco JJ, Ochsenreither S, Joshua AM, Gastaud L, Curti B, Piulats JM, Salama AKS, Shoushtari AN, Demidov L, [...] Nathan P
N Engl J Med, 389(24):2256-2266, 21 Oct 2023
Cited by: 31 articles | PMID: 37870955 | PMCID: PMC11188986
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Real-world outcomes with immuno-oncology therapies in advanced melanoma: final results of the OPTIMIzE registry study.
Kirkwood JM, Kottschade LA, McWilliams RR, Khushalani NI, Jang S, Hallmeyer S, McDermott DF, Tawbi H, Che M, Lee CH, Ritchings C, Le TK, Park B, Ramsey S
Immunotherapy, 16(1):29-42, 08 Nov 2023
Cited by: 2 articles | PMID: 37937397
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Adjuvant nivolumab in resected stage IIB/C melanoma: primary results from the randomized, phase 3 CheckMate 76K trial.
Kirkwood JM, Del Vecchio M, Weber J, Hoeller C, Grob JJ, Mohr P, Loquai C, Dutriaux C, Chiarion-Sileni V, Mackiewicz J, Rutkowski P, Arenberger P, Quereux G, Meniawy TM, Ascierto PA, Menzies AM, Durani P, Lobo M, Campigotto F, [...] Long GV
Nat Med, 29(11):2835-2843, 16 Oct 2023
Cited by: 24 articles | PMID: 37845511 | PMCID: PMC10667090
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