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Search life-sciences literature (45,103,589 articles, preprints and more)

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AAV8 gene therapy reverses cardiac pathology and prevents early mortality in a mouse model of Friedreich's ataxia.
Chang JC, Ryan MR, Stark MC, Liu S, Purushothaman P, Bolan F, Johnson CA, Champe M, Meng H, Lawlor MW, Halawani S, Ngaba LV, Lynch DR, Davis C, Gonzalo-Gil E, Lutz C, Urbinati F, Medicherla B, Fonck C
Mol Ther Methods Clin Dev, 32(1):101193, 22 Jan 2024
Cited by: 2 articles | PMID: 38352270 | PMCID: PMC10862410
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Safety Findings of Dosing Gene Therapy Vectors in NHP With Pre-existing or Treatment-Emergent Anti-capsid Antibodies.
Chandra S, Long BR, Fonck C, Melton AC, Arens J, Woloszynek J, O'Neill CA
Toxicol Pathol, 51(5):246-256, 01 Jul 2023
Cited by: 3 articles | PMID: 37921115
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Young mice administered adult doses of AAV5-hFVIII-SQ achieve therapeutic factor VIII expression into adulthood.
Zhang L, Yates B, Murphy R, Liu S, Xie L, Handyside B, Sihn CR, Bouwman T, Galicia N, Tan D, Fonck C, Arens J, Clark A, Zhang W, Chandra S, Srimani J, Holcomb J, Van Tuyl A, Henshaw J, [...] Fong S
Mol Ther Methods Clin Dev, 26:519-531, 13 Aug 2022
Cited by: 2 articles | PMID: 36092364 | PMCID: PMC9440360
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Cerebellar Pathology in an Inducible Mouse Model of Friedreich Ataxia.
Mercado-Ayón E, Warren N, Halawani S, Rodden LN, Ngaba L, Dong YN, Chang JC, Fonck C, Mavilio F, Lynch DR, Lin H
Front Neurosci, 16:819569, 24 Mar 2022
Cited by: 4 articles | PMID: 35401081 | PMCID: PMC8987918
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Muscle-directed gene therapy corrects Pompe disease and uncovers species-specific GAA immunogenicity.
Eggers M, Vannoy CH, Huang J, Purushothaman P, Brassard J, Fonck C, Meng H, Prom MJ, Lawlor MW, Cunningham J, Sadhu C, Mavilio F
EMBO Mol Med, 14(1):e13968, 01 Dec 2021
Cited by: 20 articles | PMID: 34850579 | PMCID: PMC8749482
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Lack of germline transmission in male mice following a single intravenous administration of AAV5-hFVIII-SQ gene therapy.
Fonck C, Su C, Arens J, Koziol E, Srimani J, Henshaw J, Van Tuyl A, Chandra S, Vettermann C, O'Neill CA
Gene Ther, 30(7-8):581-586, 07 Feb 2022
Cited by: 4 articles | PMID: 35132205 | PMCID: PMC10457182
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Ex Vivo Gene Therapy: Graft-versus-host Disease (GVHD) in NSG™ (NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ) Mice Transplanted with CD34⁺ Human Hematopoietic Stem Cells.
Chandra S, Cristofori P, Fonck C, O'Neill CA
Toxicol Pathol, 47(5):656-660, 07 May 2019
Cited by: 6 articles | PMID: 31064282
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The Impact of Pre-existing Immunity on the Non-clinical Pharmacodynamics of AAV5-Based Gene Therapy.
Long BR, Sandza K, Holcomb J, Crockett L, Hayes GM, Arens J, Fonck C, Tsuruda LS, Schweighardt B, O'Neill CA, Zoog S, Vettermann C
Mol Ther Methods Clin Dev, 13:440-452, 11 Apr 2019
Cited by: 36 articles | PMID: 31193016 | PMCID: PMC6513774
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CNS Adverse Effects: From Functional Observation Battery/Irwin Tests to Electrophysiology.
Fonck C, Easter A, Pietras MR, Bialecki RA
Handb Exp Pharmacol, 229:83-113, 01 Jan 2015
Cited by: 5 articles | PMID: 26091637
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Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.
O'Neill HC, Laverty DC, Patzlaff NE, Cohen BN, Fonck C, McKinney S, McIntosh JM, Lindstrom JM, Lester HA, Grady SR, Marks MJ
Pharmacol Biochem Behav, 103(3):603-621, 01 Nov 2012
Cited by: 15 articles | PMID: 23123803 | PMCID: PMC3544981
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Combining radio telemetry and automated blood sampling: a novel approach for integrative pharmacology and toxicology studies.
Kamendi HW, Brott DA, Chen Y, Litwin DC, Lengel DJ, Fonck C, Bui KH, Gorko MA, Bialecki RA
J Pharmacol Toxicol Methods, 62(1):30-39, 23 May 2010
Cited by: 8 articles | PMID: 20507819
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Human mesenchymal stromal cells and their derivative, SB623 cells, rescue neural cells via trophic support following in vitro ischemia.
Tate CC, Fonck C, McGrogan M, Case CC
Cell Transplant, 19(8):973-984, 26 Mar 2010
Cited by: 52 articles | PMID: 20350349
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Approaches to seizure risk assessment in preclinical drug discovery.
Easter A, Bell ME, Damewood JR, Redfern WS, Valentin JP, Winter MJ, Winter MJ, Fonck C, Bialecki RA
Drug Discov Today, 14(17-18):876-884, 21 Jun 2009
Cited by: 23 articles | PMID: 19545644
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Demonstration of functional alpha4-containing nicotinic receptors in the medial habenula.
Fonck C, Nashmi R, Salas R, Zhou C, Huang Q, De Biasi M, Lester RA, Lester HA
Neuropharmacology, 56(1):247-253, 26 Aug 2008
Cited by: 16 articles | PMID: 18789953 | PMCID: PMC2645341
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Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm.
Shao XM, Tan W, Xiu J, Puskar N, Fonck C, Lester HA, Feldman JL
J Neurosci, 28(2):519-528, 01 Jan 2008
Cited by: 33 articles | PMID: 18184794 | PMCID: PMC3477875
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Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation.
Teper Y, Whyte D, Cahir E, Lester HA, Grady SR, Marks MJ, Cohen BN, Fonck C, McClure-Begley T, McIntosh JM, Labarca C, Lawrence A, Chen F, Gantois I, Davies PJ, Petrou S, Murphy M, Waddington J, Horne MK, [...] Drago J
J Neurosci, 27(38):10128-10142, 01 Sep 2007
Cited by: 47 articles | PMID: 17881519 | PMCID: PMC6672658
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Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice.
Damaj MI, Fonck C, Marks MJ, Deshpande P, Labarca C, Lester HA, Collins AC, Martin BR
J Pharmacol Exp Ther, 321(3):1161-1169, 19 Mar 2007
Cited by: 45 articles | PMID: 17371806
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Knockin mice with Leu9'Ser alpha4-nicotinic receptors: substantia nigra dopaminergic neurons are hypersensitive to agonist and lost postnatally.
Orb S, Wieacker J, Labarca C, Fonck C, Lester HA, Schwarz J
Physiol Genomics, 18(3):299-307, 11 Aug 2004
Cited by: 16 articles | PMID: 15199190
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Novel seizure phenotype and sleep disruptions in knock-in mice with hypersensitive alpha 4* nicotinic receptors.
Fonck C, Cohen BN, Nashmi R, Whiteaker P, Wagenaar DA, Rodrigues-Pinguet N, Deshpande P, McKinney S, Kwoh S, Munoz J, Labarca C, Collins AC, Marks MJ, Lester HA
J Neurosci, 25(49):11396-11411, 01 Dec 2005
Cited by: 64 articles | PMID: 16339034 | PMCID: PMC6725918
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Increased sensitivity to agonist-induced seizures, straub tail, and hippocampal theta rhythm in knock-in mice carrying hypersensitive alpha 4 nicotinic receptors.
Fonck C, Nashmi R, Deshpande P, Damaj MI, Marks MJ, Riedel A, Schwarz J, Collins AC, Labarca C, Lester HA
J Neurosci, 23(7):2582-2590, 01 Apr 2003
Cited by: 39 articles | PMID: 12684443 | PMCID: PMC6742094
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Rapid reduction of ATP synthesis and lack of free radical formation by MPP+ in rat brain synaptosomes and mitochondria.
Fonck C, Baudry M
Brain Res, 975(1-2):214-221, 01 Jun 2003
Cited by: 23 articles | PMID: 12763610
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Hypersensitive knockin mouse strains identify receptors and pathways for nicotine action.
Lester HA, Fonck C, Tapper AR, McKinney S, Damaj MI, Balogh S, Owens J, Wehner JM, Collins AC, Labarca C
Curr Opin Drug Discov Devel, 6(5):633-639, 01 Sep 2003
Cited by: 18 articles | PMID: 14579512
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Autosomal recessive polycystic kidney disease in adulthood.
Fonck C, Chauveau D, Gagnadoux MF, Pirson Y, Grünfeld JP
Nephrol Dial Transplant, 16(8):1648-1652, 01 Aug 2001
Cited by: 50 articles | PMID: 11477168
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Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety.
Labarca C, Schwarz J, Deshpande P, Schwarz S, Nowak MW, Fonck C, Nashmi R, Kofuji P, Dang H, Shi W, Fidan M, Khakh BS, Chen Z, Bowers BJ, Boulter J, Wehner JM, Lester HA
Proc Natl Acad Sci U S A, 98(5):2786-2791, 20 Feb 2001
Cited by: 117 articles | PMID: 11226318 | PMCID: PMC30217
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Outcome of cadaver kidney transplantation in 23 patients with type 2 diabetes mellitus.
Mieghem AV, Fonck C, Coosemans W, Vandeleene B, Vanrenterghem Y, Squifflet JP, Pirson Y
Nephrol Dial Transplant, 16(8):1686-1691, 01 Aug 2001
Cited by: 6 articles | PMID: 11477175
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1-25 of 34 results

1 2

Search life-sciences literature (45,103,589 articles, preprints and more)

Search results

AAV8 gene therapy reverses cardiac pathology and prevents early mortality in a mouse model of Friedreich's ataxia.

Safety Findings of Dosing Gene Therapy Vectors in NHP With Pre-existing or Treatment-Emergent Anti-capsid Antibodies.

Young mice administered adult doses of AAV5-hFVIII-SQ achieve therapeutic factor VIII expression into adulthood.

Cerebellar Pathology in an Inducible Mouse Model of Friedreich Ataxia.

Muscle-directed gene therapy corrects Pompe disease and uncovers species-specific GAA immunogenicity.

Lack of germline transmission in male mice following a single intravenous administration of AAV5-hFVIII-SQ gene therapy.

Ex Vivo Gene Therapy: Graft-versus-host Disease (GVHD) in NSG™ (NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ) Mice Transplanted with CD34⁺ Human Hematopoietic Stem Cells.

The Impact of Pre-existing Immunity on the Non-clinical Pharmacodynamics of AAV5-Based Gene Therapy.

CNS Adverse Effects: From Functional Observation Battery/Irwin Tests to Electrophysiology.

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Combining radio telemetry and automated blood sampling: a novel approach for integrative pharmacology and toxicology studies.

Human mesenchymal stromal cells and their derivative, SB623 cells, rescue neural cells via trophic support following in vitro ischemia.

Approaches to seizure risk assessment in preclinical drug discovery.

Demonstration of functional alpha4-containing nicotinic receptors in the medial habenula.

Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm.

Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation.

Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice.

Knockin mice with Leu9'Ser alpha4-nicotinic receptors: substantia nigra dopaminergic neurons are hypersensitive to agonist and lost postnatally.

Novel seizure phenotype and sleep disruptions in knock-in mice with hypersensitive alpha 4* nicotinic receptors.

Increased sensitivity to agonist-induced seizures, straub tail, and hippocampal theta rhythm in knock-in mice carrying hypersensitive alpha 4 nicotinic receptors.

Rapid reduction of ATP synthesis and lack of free radical formation by MPP+ in rat brain synaptosomes and mitochondria.

Hypersensitive knockin mouse strains identify receptors and pathways for nicotine action.

Autosomal recessive polycystic kidney disease in adulthood.

Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety.

Outcome of cadaver kidney transplantation in 23 patients with type 2 diabetes mellitus.

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