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Search life-sciences literature (45,103,589 articles, preprints and more)

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Breaking Free: Development of Circular AAV Cargos for Targeted Seamless Integration in the Liver
Estes BJ, Gandhi N, Von Stetina J, Paudel D, Nan AX, Amin P, Rose J, Wu S, Zheng K, Zhang Y, Cochrane JC, Finn JD, Xie J
bioRxiv, 29 Oct 2024
Cited by: 0 articles | PPR: PPR932241
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Engineered Bxb1 variants improve integrase activity and fidelity
Rose J, Kim H, Von Stetina J, Thangavelu M, Conway H, O'Hara MS, Hanna P, Biondi T, Dunyak MT, Finn JD, Kumar S, Cochrane JC
bioRxiv, 21 Oct 2024
Cited by: 0 articles | PPR: PPR928963
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Large Serine Integrase Off-Target Discovery with Deep Learning for Genome Wide Prediction
Bakalar MH, Biondi T, Liang X, Santesmasses D, Bara AM, Mehta JB, Wang J, Hazelbaker DZ, Finn JD, O’Connell DJ
bioRxiv, 13 Oct 2024
Cited by: 0 articles | PPR: PPR923842
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Low RT-based Genome Editing Fidelity in Mouse Hepatocytes: Challenges and Solutions
Dunyak MT, Hanna P, Nan AX, von Stetina J, Pokharel R, O’Hara M, Estes BJ, Zheng K, Svenson S, Andresen J, Li W, Agrawal M, Hughes C, Spicer M, Choudhary V, Kelley L, Wang J, Meagher M, Xie J, [...] Finn JD
bioRxiv, 03 Nov 2024
Cited by: 0 articles | PPR: PPR934809
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Ligase-mediated programmable genomic integration (L-PGI): an efficient site-specific gene editing system that overcomes the limitations of reverse transcriptase-based editing systems
Nan AX, Chickering M, Bartolome C, Shadija N, Li D, Estes B, Stetina JV, Li W, Andresen J, Cochrane JC, Bai C, Gatlin J, Wang J, Norouzi D, Kumar S, Dunyak MT, Chavez L, Seth A, Halperin S, [...] Xie J
bioRxiv, 29 Sep 2024
Cited by: 0 articles | PPR: PPR919502
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Curative levels of endogenous gene replacement achieved in non-human primate liver using programmable genomic integration
Xie J, Dunyak MT, Hanna P, Nan AX, Estes B, Cochrane JC, Wu S, Wang J, McGinnis C, Wang Q, Pokharel R, Paudel D, Zhang J, Li D, Amin P, Narayan S, Hsia A, Hazelbaker DZ, Shi X, [...] Finn JD
bioRxiv, 13 Oct 2024
Cited by: 0 articles | PPR: PPR923827
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Unlocking the potential of iPSC-derived immune cells: engineering iNK and iT cells for cutting-edge immunotherapy.
Fang M, Allen A, Luo C, Finn JD
Front Immunol, 15:1457629, 30 Aug 2024
Cited by: 0 articles | PMID: 39281684 | PMCID: PMC11392856
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Large Serine Integrase Off-target Discovery and Validation for Therapeutic Genome Editing
Hazelbaker DZ, Mehta JB, McGinnis C, Santesmasses D, Bara AM, Liang X, Biondi T, Fennell T, Homer N, Estes B, Xie J, Norouzi D, Molugu K, Amunugama R, Luo C, Amin P, Shi X, Cochrane J, Kumar S, [...] O’Connell DJ
bioRxiv, 24 Aug 2024
Cited by: 0 articles | PPR: PPR900463
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Transfection reagent artefact likely accounts for some reports of extracellular vesicle function.
McConnell RE, Youniss M, Gnanasambandam B, Shah P, Zhang W, Finn JD
J Extracell Vesicles, 11(10):e12253, 01 Oct 2022
Cited by: 8 articles | PMID: 36214493 | PMCID: PMC9549734
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Evolutionary insights into coagulation factor IX Padua and other high-specific-activity variants.
Samelson-Jones BJ, Finn JD, Raffini LJ, Merricks EP, Camire RM, Nichols TC, Arruda VR
Blood Adv, 5(5):1324-1332, 01 Mar 2021
Cited by: 10 articles | PMID: 33656538 | PMCID: PMC7948292
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A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties.
Dooley K, McConnell RE, Xu K, Lewis ND, Haupt S, Youniss MR, Martin S, Sia CL, McCoy C, Moniz RJ, Burenkova O, Sanchez-Salazar J, Jang SC, Choi B, Harrison RA, Houde D, Burzyn D, Leng C, Kirwin K, [...] Williams DE
Mol Ther, 29(5):1729-1743, 21 Jan 2021
Cited by: 116 articles | PMID: 33484965 | PMCID: PMC8116569
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Timing of Intensive Immunosuppression Impacts Risk of Transgene Antibodies after AAV Gene Therapy in Nonhuman Primates.
Samelson-Jones BJ, Finn JD, Favaro P, Wright JF, Arruda VR
Mol Ther Methods Clin Dev, 17:1129-1138, 12 May 2020
Cited by: 27 articles | PMID: 32490034 | PMCID: PMC7256432
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National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries.
NCD Risk Factor Collaboration (NCD-RisC)
Int J Epidemiol, 49(1):173-192, 01 Feb 2020
Cited by: 32 articles | PMID: 31321439 | PMCID: PMC7245049
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Hyperactivity of factor IX Padua (R338L) depends on factor VIIIa cofactor activity.
Samelson-Jones BJ, Finn JD, George LA, Camire RM, Arruda VR
JCI Insight, 5:128683, 20 Jun 2019
Cited by: 26 articles | PMID: 31219805 | PMCID: PMC6675543
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Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants.
NCD Risk Factor Collaboration (NCD-RisC)
Int J Epidemiol, 47(3):872-883i, 01 Jun 2018
Cited by: 33 articles | PMID: 29579276 | PMCID: PMC6005056
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A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing.
Finn JD, Smith AR, Patel MC, Shaw L, Youniss MR, van Heteren J, Dirstine T, Ciullo C, Lescarbeau R, Seitzer J, Shah RR, Shah A, Ling D, Growe J, Pink M, Rohde E, Wood KM, Salomon WE, Harrington WF, [...] Morrissey DV
Cell Rep, 22(9):2227-2235, 01 Feb 2018
Cited by: 349 articles | PMID: 29490262
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Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults.
NCD Risk Factor Collaboration (NCD-RisC)
Lancet, 390(10113):2627-2642, 10 Oct 2017
Cited by: 3089 articles | PMID: 29029897 | PMCID: PMC5735219
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Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants.
NCD Risk Factor Collaboration (NCD-RisC)
Lancet, 389(10064):37-55, 16 Nov 2016
Cited by: 1022 articles | PMID: 27863813 | PMCID: PMC5220163
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Empty Capsids and Macrophage Inhibition/Depletion Increase rAAV Transgene Expression in Joints of Both Healthy and Arthritic Mice.
Aalbers CJ, Broekstra N, van Geldorp M, Kramer E, Ramiro S, Tak PP, Vervoordeldonk MJ, Finn JD
Hum Gene Ther, 28(2):168-178, 02 Nov 2016
Cited by: 9 articles | PMID: 27806641
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Natural history, risk factors and clinical features of primary hypogonadism in ageing men: Longitudinal Data from the European Male Ageing Study.
Ahern T, Swiecicka A, Eendebak RJ, Carter EL, Finn JD, Pye SR, O'Neill TW, Antonio L, Keevil B, Bartfai G, Casanueva FF, Forti G, Giwercman A, Han TS, Kula K, Lean ME, Pendleton N, Punab M, Rastrelli G, [...] EMAS study group
Clin Endocrinol (Oxf), 85(6):891-901, 18 Aug 2016
Cited by: 22 articles | PMID: 27374987
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Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study.
Overman MJ, Pendleton N, O'Neill TW, Bartfai G, Casanueva FF, Finn JD, Forti G, Rastrelli G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean MEJ, Punab M, Lee DM, Correa ES, Ahern T, Verschueren SMP, Antonio L, [...] EMAS Study Group
Eur J Nutr, 56(6):2093-2103, 01 Jul 2016
Cited by: 8 articles | PMID: 27370643
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Interactions Between Depression and Lower Urinary Tract Symptoms: The Role of Adverse Life Events and Inflammatory Mechanisms. Results From the European Male Ageing Study.
Castellini G, Wu FC, Finn JD, OʼNeill TW, Lean ME, Pendleton N, Rastrelli G, Rutter MK, Gacci M, Ricca V, Maggi M, EMAS Study Group
Psychosom Med, 78(6):758-769, 01 Jul 2016
Cited by: 6 articles | PMID: 27057816
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A century of trends in adult human height.
NCD Risk Factor Collaboration (NCD-RisC)
Elife, 5:e13410, 26 Jul 2016
Cited by: 182 articles | PMID: 27458798 | PMCID: PMC4961475
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Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants.
NCD Risk Factor Collaboration (NCD-RisC)
Lancet, 387(10027):1513-1530, 06 Apr 2016
Cited by: 1700 articles | PMID: 27061677 | PMCID: PMC5081106
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Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study.
McCabe PS, Pye SR, Beth JM, Lee DM, Tajar A, Bartfai G, Boonen S, Bouillon R, Casanueva F, Finn JD, Forti G, Giwercman A, Huhtaniemi IT, Kula K, Pendleton N, Punab M, Vanderschueren D, Wu FC, O'Neill TW, EMAS Study Group
BMC Musculoskelet Disord, 17:32, 16 Jan 2016
Cited by: 14 articles | PMID: 26774507 | PMCID: PMC4715359
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