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Search life-sciences literature (45,103,589 articles, preprints and more)

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Targeting NAD+ Metabolism Vulnerability in FH-Deficient Hereditary Leiomyomatosis and Renal Cell Carcinoma with the novel NAMPT Inhibitor OT-82.
Najera SS, Ricketts CJ, Schmidt LS, Medina JI, Saito K, Ileva L, Brender JR, James AM, Peer CJ, Gouker B, Karim BO, Chernova O, Wells C, Wei MH, Yang Y, Zhang X, Klumpp-Thomas C, Travers J, Chen L, [...] Meier JL
Mol Cancer Ther, 14 Oct 2024
Cited by: 0 articles | PMID: 39397296
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A patient-derived cell model for malignant transformation in IDH-mutant glioma.
Kim O, Sergi Z, Yu G, Yamamoto K, Quezado M, Abdullaev Z, Crooks DR, Kishimoto S, Li Q, Lu P, Blackman B, Andresson T, Wu X, Tran B, Wei JS, Zhang W, Zhang M, Song H, Khan J, [...] Wu J
Acta Neuropathol Commun, 12(1):148, 10 Sep 2024
Cited by: 0 articles | PMID: 39256867 | PMCID: PMC11385154
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Pharmacologic ascorbate induces transient hypoxia sensitizing pancreatic ductal adenocarcinoma to a hypoxia activated prodrug.
Kishimoto S, Crooks DR, Yasunori O, Kota Y, Yamamoto K, Linehan WM, Levine M, Krishna MC, Brender JR
Free Radic Biol Med, 222:579-587, 09 Jul 2024
Cited by: 0 articles | PMID: 38992394
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Molecular Characterization of Metastatic Oncocytoma With Exceptional Response to Treatment: A Case Report.
Webster BR, Ricketts CJ, Vocke CD, Gamble D, Crooks DR, Yang Y, Friedman L, Toubaji A, Msaouel P, Hernandez JM, Linehan WM, Ball MW
JCO Precis Oncol, 8:e2400188, 01 Jul 2024
Cited by: 0 articles | PMID: 39038244
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Pharmacological Ascorbate Induces Transient Hypoxia Sensitizing Pancreatic Ductal Adenocarcinoma to a Hypoxia Activated Prodrug
Kishimoto S, Crooks DR, Yasunori O, Kota Y, Yamamoto K, Linehan WM, Levine M, Krishna MC, Brender JR
bioRxiv, 15 May 2024
Cited by: 0 articles | PPR: PPR853778
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Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma.
Fitzsimmons CM, Mandler MD, Lunger JC, Chan D, Maligireddy SS, Schmiechen AC, Gamage ST, Link C, Jenkins LM, Chan K, Andresson T, Crooks DR, Meier JL, Linehan WM, Batista PJ
NAR Cancer, 6(1):zcae004, 07 Feb 2024
Cited by: 4 articles | PMID: 38328795 | PMCID: PMC10849186
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Metabolic and imaging phenotypes associated withRB1loss in castrate resistant prostate cancer
Ahmad F, White M, Yamamoto K, Crooks DR, Agarwal S, Yang Y, Capaldo B, Raj S, Alilin AN, Ton A, Adler S, Seidel J, Olkowski C, Cherukuri MK, Choyke PL, Kelly K, Brender JR
bioRxiv, 17 Nov 2023
Cited by: 0 articles | PPR: PPR760794
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Cryptic splice mutation in the fumarate hydratase gene in patients with clinical manifestations of Hereditary Leiomyomatosis and Renal Cell Cancer.
Crooks DR, Cawthon GM, Fitzsimmons CM, Perez M, Ricketts CJ, Vocke CD, Yang Y, Middelton L, Nielsen D, Schmidt LS, Tandon M, Merino MJ, Ball MW, Meier JL, Batista PJ, Linehan WM
Hum Mol Genet, 32(22):3135-3145, 01 Nov 2023
Cited by: 0 articles | PMID: 37561409 | PMCID: PMC10630246
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PRDM10 RCC: A Birt-Hogg-Dubé-like Syndrome Associated With Lipoma and Highly Penetrant, Aggressive Renal Tumors Morphologically Resembling Type 2 Papillary Renal Cell Carcinoma.
Schmidt LS, Vocke CD, Ricketts CJ, Blake Z, Choo KK, Nielsen D, Gautam R, Crooks DR, Reynolds KL, Krolus JL, Bashyal M, Karim B, Cowen EW, Malayeri AA, Merino MJ, Srinivasan R, Ball MW, Zbar B, Marston Linehan W
Urology, 179:58-70, 16 Jun 2023
Cited by: 8 articles | PMID: 37331486 | PMCID: PMC10592549
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High-throughput and targeted drug screens identify pharmacological candidates against MiT-translocation renal cell carcinoma.
Lang M, Schmidt LS, Wilson KM, Ricketts CJ, Sourbier C, Vocke CD, Wei D, Crooks DR, Yang Y, Gibbs BK, Zhang X, Klumpp-Thomas C, Chen L, Guha R, Ferrer M, McKnight C, Itkin Z, Wangsa D, Wangsa D, [...] Linehan WM
J Exp Clin Cancer Res, 42(1):99, 25 Apr 2023
Cited by: 4 articles | PMID: 37095531 | PMCID: PMC10127337
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Targeting mutant p53-R248W reactivates WT p53 function and alters the onco-metabolic profile.
Brown K, Jenkins LMM, Crooks DR, Surman DR, Mazur SJ, Xu Y, Arimilli BS, Yang Y, Lane AN, Fan TW, Schrump DS, Linehan WM, Ripley RT, Appella E
Front Oncol, 12:1094210, 11 Jan 2023
Cited by: 2 articles | PMID: 36713582 | PMCID: PMC9874945
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Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma
Fitzsimmons CM, Mandler MD, Lunger JC, Chan D, Maligireddy SS, Schmiechen AC, Gamage ST, Link C, Jenkins LM, Crooks DR, Meier JL, Linehan WM, Batista PJ
bioRxiv, 10 Apr 2023
Cited by: 0 articles | PPR: PPR643501
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Resolving Enantiomers of 2-Hydroxy Acids by Nuclear Magnetic Resonance.
Lin P, Crooks DR, Linehan WM, Fan TW, Lane AN
Anal Chem, 94(36):12286-12291, 30 Aug 2022
Cited by: 2 articles | PMID: 36040304 | PMCID: PMC9539631
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Real-Time insight into in vivo redox status utilizing hyperpolarized [1-¹³C] N-acetyl cysteine.
Yamamoto K, Opina A, Sail D, Blackman B, Saito K, Brender JR, Malinowski RM, Seki T, Oshima N, Crooks DR, Kishimoto S, Saida Y, Otowa Y, Choyke PL, Ardenkjær-Larsen JH, Mitchell JB, Linehan WM, Swenson RE, Krishna MC
Sci Rep, 11(1):12155, 09 Jun 2021
Cited by: 7 articles | PMID: 34108512 | PMCID: PMC8190077
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NMR Methods for Determining Lipid Turnover via Stable Isotope Resolved Metabolomics.
Lin P, Dai L, Crooks DR, Neckers LM, Higashi RM, Fan TW, Lane AN
Metabolites, 11(4):202, 29 Mar 2021
Cited by: 11 articles | PMID: 33805301 | PMCID: PMC8065598
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Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer.
Crooks DR, Maio N, Lang M, Ricketts CJ, Vocke CD, Gurram S, Turan S, Kim YY, Cawthon GM, Sohelian F, De Val N, Pfeiffer RM, Jailwala P, Tandon M, Tran B, Fan TW, Lane AN, Ried T, Wangsa D, [...] Linehan WM
Sci Signal, 14(664):eabc4436, 05 Jan 2021
Cited by: 43 articles | PMID: 33402335 | PMCID: PMC8039187
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Multifocal Renal Cell Carcinomas With Somatic IDH2 Mutation: Report of a Previously Undescribed Neoplasm.
Merino MJ, Ricketts CJ, Moreno V, Yang Y, Fan TWM, Lane AN, Meltzer PS, Vocke CD, Crooks DR, Linehan WM
Am J Surg Pathol, 45(1):137-142, 01 Jan 2021
Cited by: 5 articles | PMID: 33165095 | PMCID: PMC7736215
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Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite.
Perez M, Bak DW, Bergholtz SE, Crooks DR, Arimilli BS, Yang Y, Weerapana E, Linehan WM, Meier JL
J Biol Chem, 295(39):13410-13418, 19 Aug 2020
Cited by: 4 articles | PMID: 32820045 | PMCID: PMC7521642
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Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway.
Panarsky R, Crooks DR, Lane AN, Yang Y, Cassel TA, Fan TW, Linehan WM, Moscow JA
Cancer Metab, 8:7, 03 Aug 2020
Cited by: 2 articles | PMID: 32774853 | PMCID: PMC7397616
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Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite
Perez M, Bak DW, Bergholtz SE, Crooks DR, Yang Y, Weerapana E, Linehan WM, Meier JL
bioRxiv, 26 Jun 2020
Cited by: 0 articles | PPR: PPR180814
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In vivodeuterated water labeling allows tumor visualization via deuterium magnetic resonance spectroscopic imaging of cholesterol
Assmann JC, Brender JR, Farthing DE, Saito K, Kishimoto S, Warrick KA, Maglakelidze N, Crooks DR, Merkle H, Gress RE, Krishna MC, Buxbaum NP
bioRxiv, 17 Oct 2019
Cited by: 0 articles | PPR: PPR98821
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Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice.
Kishimoto S, Brender JR, Crooks DR, Matsumoto S, Seki T, Oshima N, Merkle H, Lin P, Reed G, Chen AP, Ardenkjaer-Larsen JH, Munasinghe J, Saito K, Yamamoto K, Choyke PL, Mitchell J, Lane AN, Fan TW, Linehan WM, Krishna MC
Elife, 8:e46312, 13 Aug 2019
Cited by: 11 articles | PMID: 31408004 | PMCID: PMC6706239
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Targeting Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor 2 (HER2) Expressing Bladder Cancer Using Combination Photoimmunotherapy (PIT).
Siddiqui MR, Railkar R, Sanford T, Crooks DR, Eckhaus MA, Haines D, Choyke PL, Kobayashi H, Agarwal PK
Sci Rep, 9(1):2084, 14 Feb 2019
Cited by: 38 articles | PMID: 30765854 | PMCID: PMC6375935
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Metabolic Labeling of Cultured Mammalian Cells for Stable Isotope-Resolved Metabolomics: Practical Aspects of Tissue Culture and Sample Extraction.
Crooks DR, Fan TW, Linehan WM
Methods Mol Biol, 1928:1-27, 01 Jan 2019
Cited by: 11 articles | PMID: 30725447 | PMCID: PMC8195444
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The Metabolic Basis of Kidney Cancer.
Linehan WM, Schmidt LS, Crooks DR, Wei D, Srinivasan R, Lang M, Ricketts CJ
Cancer Discov, 9(8):1006-1021, 14 May 2019
Cited by: 132 articles | PMID: 31088840
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1-25 of 52 results

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Search life-sciences literature (45,103,589 articles, preprints and more)

Search results

Targeting NAD+ Metabolism Vulnerability in FH-Deficient Hereditary Leiomyomatosis and Renal Cell Carcinoma with the novel NAMPT Inhibitor OT-82.

A patient-derived cell model for malignant transformation in IDH-mutant glioma.

Pharmacologic ascorbate induces transient hypoxia sensitizing pancreatic ductal adenocarcinoma to a hypoxia activated prodrug.

Molecular Characterization of Metastatic Oncocytoma With Exceptional Response to Treatment: A Case Report.

Pharmacological Ascorbate Induces Transient Hypoxia Sensitizing Pancreatic Ductal Adenocarcinoma to a Hypoxia Activated Prodrug

Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma.

Metabolic and imaging phenotypes associated withRB1loss in castrate resistant prostate cancer

Cryptic splice mutation in the fumarate hydratase gene in patients with clinical manifestations of Hereditary Leiomyomatosis and Renal Cell Cancer.

PRDM10 RCC: A Birt-Hogg-Dubé-like Syndrome Associated With Lipoma and Highly Penetrant, Aggressive Renal Tumors Morphologically Resembling Type 2 Papillary Renal Cell Carcinoma.

High-throughput and targeted drug screens identify pharmacological candidates against MiT-translocation renal cell carcinoma.

Targeting mutant p53-R248W reactivates WT p53 function and alters the onco-metabolic profile.

Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma

Resolving Enantiomers of 2-Hydroxy Acids by Nuclear Magnetic Resonance.

Real-Time insight into in vivo redox status utilizing hyperpolarized [1-¹³C] N-acetyl cysteine.

NMR Methods for Determining Lipid Turnover via Stable Isotope Resolved Metabolomics.

Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer.

Multifocal Renal Cell Carcinomas With Somatic IDH2 Mutation: Report of a Previously Undescribed Neoplasm.

Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite.

Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway.

Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite

In vivodeuterated water labeling allows tumor visualization via deuterium magnetic resonance spectroscopic imaging of cholesterol

Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice.

Targeting Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor 2 (HER2) Expressing Bladder Cancer Using Combination Photoimmunotherapy (PIT).

Metabolic Labeling of Cultured Mammalian Cells for Stable Isotope-Resolved Metabolomics: Practical Aspects of Tissue Culture and Sample Extraction.

The Metabolic Basis of Kidney Cancer.

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