Figure 1

Information flow and integration in the Cancer Digital Slide Archive (CDSA). Whole-slide images (WSIs) and other data types are mirrored from The Cancer Genome Atlas repository. Radiology data from The Cancer Imaging Archive is downloaded and organized within an XNAT research PACs. These data sources are integrated using a MySQL database to register the available data and associations between elements. The CDSA portal draws on information from the MySQL database, as well as metadata from the Memorial Sloan Kettering cBioPortal, and image analysis results from a local instance of the Pathology Analytical Imaging Standards (PAIS) database. WSIs are converted into web-friendly formats and served through CDSA using VIPS, IIP, and OpenSlide.