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The gamma-subunit of the acetylcholine receptor is not expressed in the levator palpebrae superioris.

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Affiliations

  • 1. Department of Neurology, Case Western Reserve University School of Medicine, OH 44106.
      Authors
    • Kaminski HJ 1
    (1 author)

ORCIDs linked to this article

Neurology, 01 Mar 1995, 45(3 Pt 1):516-518
https://doi.org/10.1212/wnl.45.3.516 PMID: 7898708 

Abstract 

In extraocular muscle (EOM), expression of the gamma-subunit, which is associated with the fetal-type acetylcholine receptor (AChR), may offer a differential target for immune-mediated damage and could explain the preponderance of ocular manifestations caused by myasthenia gravis (MG). Using Poly(A)+ RNA hybridization, we investigated expression of the gamma-subunit in bovine levator palpebrae superioris (LP), a muscle also differentially involved by MG. There were no transcripts of the gamma-subunit of the AChR, but the epsilon-subunit, associated with the adult-type AChR, was present. The results indicate that the susceptibility of LP to MG is not mediated by gamma-subunit expression and suggest that multiterminal fibers in EOM may be the site of gamma-subunit expression.

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Read article at publisher's site: https://doi.org/10.1212/wnl.45.3.516

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Funding 

Funders who supported this work.

NEI NIH HHS (1)