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Epidemiological impact of Neisseria gonorrhoeae and Chlamydia trachomatis screening in men having sex with men: a modelling study.

Collaborators (366)

Author information

Affiliations

  • 1. EPIMOD, Lyon, France.
      Authors
    • Flaig J 1
    • Voirin N 1
    (2 authors)
  • 2. Infectious Diseases, CHU d'Orléans, Orléans, France
      Authors
    • Hocqueloux L 2
    (1 author)
  • 3. Department of Infectious Diseases, Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Pitié Salpêtrière Hospital, Paris, France.
      Authors
    • Palich R 3
    (1 author)
  • 4. CHU de Martinique, Fort-de-France, Martinique.
      Authors
    • Cuzin L 4
    (1 author)
  • 5. CH Gustave Dron de Tourcoing, Tourcoing, France.
      Authors
    • Robineau O 5
    (1 author)
    • Show all (8)

ORCIDs linked to this article

Show all (6)

Sexually Transmitted Infections, 19 Aug 2024, 100(6):349-355
https://doi.org/10.1136/sextrans-2023-056103 PMID: 38789265 

Abstract 

Objectives

The impact of the systematic screening of Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) in men having sex with men (MSM) on these pathogens' epidemiology remains unclear. We conducted a modelling study to analyse this impact in French MSM.

Methods

We modelled NG and CT transmission using a site-specific deterministic compartmental model. We calibrated NG and CT prevalence at baseline using results from MSM enrolled in the Dat'AIDS cohort. The baseline scenario was based on 1 million MSM, 40 000 of whom were tested every 90 days and 960 000 every 200 days. Incidence rate ratios (IRRs) at steady state were simulated for NG, CT, NG and/or CT infections, for different combinations of tested sites, testing frequency and numbers of frequently tested patients.

Results

The observed prevalence rate was 11.0%, 10.5% and 19.1% for NG, CT and NG and/or CT infections. The baseline incidence rate was estimated at 138.2 per year per 100 individuals (/100PY), 86.8/100PY and 225.0/100PY for NG, CT and NG and/or CT infections. Systematically testing anal, pharyngeal and urethral sites at the same time reduced incidence by 14%, 23% and 18% (IRR: 0.86, 0.77 and 0.82) for NG, CT and NG and/or CT infections. Reducing the screening interval to 60 days in frequently tested patients reduced incidence by 20%, 29% and 24% (IRR: 0.80, 0.71 and 0.76) for NG, CT and NG and/or CT infections. Increasing the number of frequently tested patients to 200 000 reduced incidence by 29%, 40% and 33% (IRR: 0.71, 0.60 and 0.67) for NG, CT and NG and/or CT infections. No realistic scenario could decrease pathogens' incidence by more than 50%.

Conclusions

To curb the epidemic of NG and CT in MSM, it would not only be necessary to drastically increase screening, but also to add other combined interventions.

Full text links 

Read article at publisher's site: https://doi.org/10.1136/sextrans-2023-056103

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