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Titration of Sedentary Behavior With Varying Physical Activity Levels Reduces Mortality in Patients With Type 2 Diabetes.

Author information

Affiliations

  • 1. Department of Cardiology, Guangdong Provincial Key Laboratory of Heart Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
      Authors
    • Liu J 1
    • Ai C 1
    • Li Z 1
    • Huang X 1
    • Zheng C 1
    • Bin J 1, 2
    • Lin H 1
    • Liao Y 1, 2
    (8 authors)
  • 2. Cardiovascular Center, The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Foshan 528200, China.
      Authors
    • Shen M 2
    • Bin J 1, 2
    • Guan Z 2, 4
    • Liao Y 1, 2
    (4 authors)
  • 3. Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou Guangdong 510515, China.
      Authors
    • Liao W 3
    (1 author)
  • 4. School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
      Authors
    • Li J 4
    • Guan Z 2, 4
    (2 authors)

ORCIDs linked to this article

The Journal of Clinical Endocrinology and Metabolism, 01 Nov 2024, 109(12):3156-3165
https://doi.org/10.1210/clinem/dgae323 PMID: 38739731 

Abstract 

Context

Both physical activity (PA) and sedentary behavior (SB) exert an important impact on type 2 diabetes, but it remains unclear regarding how the maximum impact on improving mortality by an optimized proportion of the two lifestyles can be achieved.

Objective

To explore the impacts of PA/SB combinations on mortality in patients with diabetes.

Methods

Patients with type 2 diabetes samplings were collected from the National Health and Nutrition Examination Survey dataset. Their lifestyles were categorized into 8 groups based on combinations of the PA and SB levels. Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals.

Results

During the follow-up period, 1148 deaths (18.94%) were recorded. High SB (sedentary time ≥6 hours/day) was significantly associated with higher all-cause mortality [hazards ratio (HR) 1.65]. In participants with low SB (<6 hours/day), low PA was associated with lower all-cause mortality (HR 0.43), while a further increase of PA level did not show further reductions in either all-cause or cardiovascular mortality. In contrast, in participants with high SB, all levels of PA were associated with lower all-cause mortality (P < .05), but only moderate PA was associated with lower cardiovascular mortality (HR 0.30).

Conclusion

In patients with type 2 diabetes, different combinations of various levels of PA and SB are associated with different degrees of risk for all-cause or cardiovascular mortality.

Full text links 

Read article at publisher's site: https://doi.org/10.1210/clinem/dgae323

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Funding 

Funders who supported this work.

Chinese Postdoctoral Science Foundation (1)

Municipal Project of Research and Utilization of Healthcare Key Technology (1)

National Natural Science Foundation of China (2)