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Antimicrobial resistance and phylogenetic relatedness of extended-spectrum ß-lactamase (ESBL)-producing Escherichia coli in peridomestic rats (Rattus norvegicus and Rattus tanezumi) linked to city areas and animal farms in Hong Kong.

Author information

Affiliations

  • 1. Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine, City University of Hong Kong, Kowloon Tong, Hong Kong Special Administrative Region, China.
      Authors
    • Uea-Anuwong T 1
    • Biggel M 1
    • Lugsomya K 1
    • Kiu LH 1
    (4 authors)
  • 2. Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, 8057, Zurich, Switzerland.
      Authors
    • Cernela N 2
    • Boss S 2
    • Stephan R 2
    • Nüesch-Inderbinen M 2
    (4 authors)
  • 3. Centre for Applied One Health Research and Policy Advice, City University of Hong Kong, Kowloon Tong, Hong Kong Special Administrative Region, China.
      Authors
    • Hung WW 3
    (1 author)
  • 4. Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
      Authors
    • Gröhn YT 4
    (1 author)
  • 5. Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine, City University of Hong Kong, Kowloon Tong, Hong Kong Special Administrative Region, China; Centre for Applied One Health Research and Policy Advice, City University of Hong Kong, Kowloon Tong, Hong Kong Special Administrative Region, China.
      Authors
    • Magouras I 5
    (1 author)

ORCIDs linked to this article

Environmental Research, 08 Mar 2024, 251(Pt 1):118623
https://doi.org/10.1016/j.envres.2024.118623 PMID: 38462086 

Abstract 

Extended-spectrum β-lactamase-producing Escherichia (E.) coli (ESBL-EC) in the clinical setting have emerged as a major threat to public and animal health. Wildlife, including Rattus spp. may serve as reservoirs and spreaders of ESBL-EC in the environment. Peridomestic rats are well adapted to living in proximity to humans and animals in a variety of urban and agricultural environments and may serve as sentinels to identify variations of ESBL-EC within their different habitats. In this study, a set of 221 rats (Rattus norvegicus, R. tanezumi, R. andamanensis, and Niviventer huang) consisting of 104 rats from city areas, 44 from chicken farms, 52 from pig farms, and 21 from stables of horse-riding schools were screened for ESBL-EC. Overall, a total of 134 ESBL-EC were isolated from the caecal samples of 130 (59%) rats. The predominant blaESBL genes were blaCTX-M-14, blaCTX-M-15, blaCTX-M-55, and blaCTX-M-65. Phylogenetic analysis revealed a total of 62 sequence types (STs) and 17 SNP clusters. E. coli ST10 and ST155 were common to ESBL-EC from city areas and chicken farms, and ST44 were found among ESBL-EC from city areas and pig farms. Extra-intestinal pathogenic E. coli (ExPEC) ST69, ST131 and ST1193 were found exclusively among rats from city areas, and avian pathogenic E. coli (APEC) ST177 was restricted to ESBL-EC originating from chicken farms. Phylogenetic analysis showed that the populations of rodent ESBL-EC from city areas, chicken farms and pig farms were genetically different, suggesting a certain degree of partitioning between the human and animal locations. This study contributes to current understanding of ESBL-EC occurring in rats in ecologically diverse locations.

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Read article at publisher's site: https://doi.org/10.1016/j.envres.2024.118623

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