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A Historic Cohort Analysis of Radiographic and Serologic Findings in Patients With Scleroderma and Interstitial Lung Disease.

Author information

Affiliations

  • 1. From the Departments of Internal Medicine.
      Authors
    • Jhawar N 1
    • Wilson C 1
    (2 authors)
  • 2. Quantitative Health Sciences.
      Authors
    • Li Z 2
    • Ma Y 2
    (2 authors)
  • 3. Rheumatology, Mayo Clinic, Jacksonville, FL.
      Authors
    • Abril A 3
    (1 author)

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases, 20 Nov 2023, 30(1):e18-e22
https://doi.org/10.1097/rhu.0000000000002042 PMID: 37983683 

Abstract 

Background/objective

Few studies have investigated associations between rheumatologic serology patterns and different interstitial lung disease (ILD) patterns.

Methods

We present novel findings of a historic cohort study (n = 454) with data collected from 2011 to 2021 within our hospital system. In this institutional review board-approved study, data regarding rheumatologic serologies and ILD patterns were noted based on chart review in patients with scleroderma. The Kruskal-Wallis rank sum and χ2 tests were used for statistical analysis.

Results

Results showed a statistically significant association between anti-U1 snRNP with lymphoid interstitial pneumonia, which has not been previously described.

Conclusions

We demonstrated novel serologic associations with ILD patterns, which have important clinical implications. More robust and high-powered studies are needed to elucidate the role of serologic testing and their association with ILD phenotypes.

Full text links 

Read article at publisher's site: https://doi.org/10.1097/rhu.0000000000002042

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