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Detection of Cancer-Derived Exosomes Using a Sensitive Colorimetric Aptasensor.

Author information

Affiliations

  • 1. Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, China.
      Authors
    • Xu L 1, 2
    (1 author)
  • 2. Institute for Pharmaceutical Science, King's College London, London, UK.
      Authors
    • Xu L 1, 2
    • Al-Jamal KT 2
    (2 authors)

ORCIDs linked to this article

Methods in Molecular Biology (Clifton, N.J.), 01 Jan 2022, 2504:21-30
https://doi.org/10.1007/978-1-0716-2341-1_2 PMID: 35467276 

Abstract 

Exosomes are a type of extracellular vesicles that contain constituents including proteins, DNAs, and RNAs of the cells that secrete them. Cancerous exosomes are potential biomarkers for cancer diagnosis. Biosensors are useful analytical tools for quantification of biomarkers and targeted molecules. An aptasensor uses the aptamer as the biorecognition element to bind to the target and is one main type of biosensors that is promising for exosomes analysis and clinical cancer detection. The assay described in this chapter allows for reliable, sensitive, and specific detection of cancer-derived exosomes using a colorimetric aptasensor that is promising for point-of-care testing.

Full text links 

Read article at publisher's site: https://doi.org/10.1007/978-1-0716-2341-1_2

References 

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