Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Ablation of IL-17 expression moderates experimental autoimmune myasthenia gravis disease severity.

Author information

Affiliations

  • 1. Departments of Neurology, George Washington University, Washington, DC, USA.
      Authors
    • Aguilo-Seara G 1
    • Xie Y 1
    (2 authors)
  • 2. Pharmacology & Physiology, George Washington University, Washington, DC, USA.
      Authors
    • Sheehan J 2
    (1 author)
  • 3. Departments of Neurology, George Washington University, Washington, DC, USA; Pharmacology & Physiology, George Washington University, Washington, DC, USA.
      Authors
    • Kusner LL 3
    • Kaminski HJ 3
    (2 authors)

ORCIDs linked to this article

Cytokine, 06 Jun 2017, 96:279-285
https://doi.org/10.1016/j.cyto.2017.05.008 PMID: 28599246 

Abstract 

An array of cytokines influences the pathogenesis of early onset myasthenia gravis (MG) and its animal model, experimental autoimmune myasthenia gravis (EAMG). Patients with MG, in particular those with more severe weakness, have elevations of the pro-inflammatory cytokine IL-17 in the blood. We assessed the role of IL-17A in autoimmunity by inducing EAMG in mice with knockout of IL-17 and found a reduction of EAMG severity, but not a complete ablation of disease. The IL-17ko mice had no evidence of weakness, low levels of acetylcholine receptor antibodies, and retention of acetylcholine receptor at the neuromuscular junction. Splenic germinal center size was reduced in EAMG IL-17ko mice along with elevations of Foxp3 and BCL-6 gene expression, suggesting a shift away from pro-inflammatory signals. The results emphasize the importance of IL-17 in EAMG development and that IL-17 independent pathways drive the autoimmune reaction.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.cyto.2017.05.008

References 

Articles referenced by this article (27)

Show 10 more references (10 of 27)

Citations & impact 

Impact metrics

18
Citations
Jump to Citations
3
Data citations
Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/20942785
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/20942785

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/j.cyto.2017.05.008

Supporting
Mentioning
Contrasting
0
20
0

Article citations

Go to all (18) article citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.