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Corticotropin-releasing hormone and dopamine release in healthy individuals.

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Affiliations

  • 1. Research Imaging Centre, Centre for Addiction and Mental Health, 250 College St., Toronto, ON, Canada; Addictions Division, Centre for Addiction and Mental Health, 100 Stokes St., Toronto, ON, Canada; Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, 250 College St., Toronto, ON, Canada.
      Authors
    • Payer D 1
    (1 author)
  • 2. Research Imaging Centre, Centre for Addiction and Mental Health, 250 College St., Toronto, ON, Canada.
      Authors
    • Williams B 2
    • Mansouri E 2
    • Stevanovski S 2
    • Nakajima S 2
    (4 authors)
  • 3. Research Imaging Centre, Centre for Addiction and Mental Health, 250 College St., Toronto, ON, Canada; Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, 250 College St., Toronto, ON, Canada; Departments of Medicine, Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada.
      Authors
    • Le Foll B 3
    • Kish S 3
    (2 authors)
  • 4. Research Imaging Centre, Centre for Addiction and Mental Health, 250 College St., Toronto, ON, Canada; Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, 250 College St., Toronto, ON, Canada.
      Authors
    • Houle S 4
    • Mizrahi R 4
    • Boileau I 4
    (3 authors)
  • 5. Departments of Medicine, Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada.
      Authors
    • George SR 5
    (1 author)
    • Show all (6)

ORCIDs linked to this article

Psychoneuroendocrinology, 01 Dec 2016, 76:192-196
https://doi.org/10.1016/j.psyneuen.2016.11.034 PMID: 27951520 

Abstract 

Corticotropin-releasing hormone (CRH) is a key component of the neuroendocrine response to stress. In animal models, CRH has been shown to modulate dopamine release, and this interaction is believed to contribute to stress-induced relapse in neuropsychiatric disorders. Here we investigated whether CRH administration induces dopamine release in humans, using positron emission tomography (PET). Eight healthy volunteers (5 female, 22-48 years old) completed two PET scans with the dopamine D2/3 receptor radioligand [11C]-(+)-PHNO: once after saline injection, and once after injection of corticorelin (synthetic human CRH). We also assessed subjective reports and measured plasma levels of endocrine hormones (adrenocorticotropic hormone and cortisol). Relative to saline, corticorelin administration decreased binding of the D2/3 PET probe [11C]-(+)-PHNO, suggesting dopamine release. Endocrine stress markers were also elevated, in line with activation of the hypothalamic-pituitary-adrenal axis, but we detected no changes in subjective ratings. Preliminary results from this proof-of-concept study suggests that CRH challenge in combination with [11C]-(+)-PHNO PET may serve as an assay of dopamine release, presenting a potential platform for evaluating CRH/dopamine interactions in neuropsychiatric disorders and CRH antagonists as potential treatment avenues.

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Read article at publisher's site: https://doi.org/10.1016/j.psyneuen.2016.11.034

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