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Single fiber EMG as an outcome measure in myasthenia gravis: results from a double-blind, placebo-controlled trial.

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Affiliations

  • 1. Department of Neurological Sciences, Rush University, Chicago, Illinois 60612, USA.
      Authors
    • Meriggioli MN 1
    (1 author)

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society, 01 Sep 2003, 20(5):382-385
https://doi.org/10.1097/00004691-200309000-00011 PMID: 14702000 

Abstract 

In a placebo-controlled, therapeutic, pilot trial of mycophenolate mofetil (MM) in autoimmune myasthenia gravis (MG), the authors compared pretreatment and posttreatment single fiber electromyography (SFEMG) jitter measurements performed on the same muscle in a total of 11 patients. The mean jitter value decreased (improved) by an average of 15.4 micros in patients receiving MM (n = 6), compared to an increase (worsening) in mean jitter of 4.0 micros in patients receiving placebo (n = 5). This difference was statistically significant (P = 0.030). In most patients, the change in SFEMG measurements correlated with the change in clinical state as measured by quantitative testing of muscle function. The authors conclude that immunomodulation by MM improves neuromuscular junction function in MG and that SFEMG may be a useful marker of early response in future therapeutic trials in autoimmune MG.

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Read article at publisher's site: https://doi.org/10.1097/00004691-200309000-00011

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