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Altered T cell signalling in ageing.

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Affiliations

  • 1. Tübingen Ageing and Tumour Immunology Group, Second Department of Internal Medicine, University of Tübingen Medical School, Zentrum für Medizinsche Forschung, Waldhörnlestr. 22, D-72072, Tubingen, Germany.
      Authors
    • Pawelec G 1
    (1 author)

Mechanisms of Ageing and Development, 01 Sep 2001, 122(14):1613-1637
https://doi.org/10.1016/s0047-6374(01)00290-1 PMID: 11511400 

Review

Abstract 

T cell responses are altered in the aged in a manner usually interpreted as detrimental to host defences against infectious agents and possibly also against cancer. T cell dysregulation may be caused by any or a combination of stem cell deficits, compromised T cell differentiation, inefficient antigen processing and presentation by antigen presenting cells, suboptimal processing of the antigenic signal by T cells or inability of the T cell to respond appropriately thereafter. This review will focus on altered T cell signalling in ageing, encompassing not only alterations in signal transduction by the antigen-specific T cell receptor, but changes in the balance of positive and negative T cell costimulation and the resultant modified cytokine environment, the response to which is itself altered in ageing.

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Read article at publisher's site: https://doi.org/10.1016/s0047-6374(01)00290-1

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