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Preclinical investigations and first-in-human application of $^{152}$Tb-PSMA-617 for PET/CT imaging of prostate cancer / Müller, Cristina (PSI, Villigen) ; Singh, Aviral (Unlisted, DE ; Unlisted, NL) ; Umbricht, Christoph A (PSI, Villigen) ; Kulkarni, Harshad R (Unlisted, DE) ; Johnston, Karl (CERN) ; Benešová, Martina (PSI, Villigen) ; Senftleben, Stefan (Unlisted, DE) ; Müller, Dirk (Unlisted, DE) ; Vermeulen, Christiaan (PSI, Villigen) ; Schibli, Roger (ETH, Zurich (main) ; PSI, Villigen) et al.
The results of this study demonstrate the successful preparation and preclinical testing of $^{152}$Tb-PSMA-617 and its first application in a patient with mCRPC. This work could pave the way towards clinical application of other Tb radionuclides in the near future, most importantly $^{161}$Tb, which has promising decay characteristics for an effective treatment of mCRPC patients..
2019 - 10 p. - Published in : EJNMMI Res. 9 (2019) 68 fulltext from publisher: PDF;

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Clinical evaluation of the radiolanthanide terbium-152: first-in-human PET/CT with $^152$Tb-DOTATOC / Baum, Richard P (Zentralklinik, Bad Berka) ; Singh, Aviral (Zerntralklinik, Bad Berka) ; Benešová, Martina (PSI, Villigen ; ETH, Zurich (main)) ; Vermeulen, Christiaan (PSI, Villigen) ; Gnesin, Silvano (Lausanne U. Hospital, Lausanne) ; Köster, Ulli (Laue-Langevin Inst.) ; Johnston, Karl (CERN) ; Müller, Dirk (Zentralklinik, Bad Berka) ; Senftleben, Stefan (Zentralklinik, Bad Berka) ; Kulkarni, Harshad R (Zentralklinik, Bad Berka) et al.
The existence of theragnostic pairs of radionuclides allows the preparation of radiopharmaceuticals for diagnostic and therapeutic purposes. Radiolanthanides, such as $^{177}$Lu, are successfully used for therapeutic purposes; however, a perfect diagnostic match is currently not available for clinical use. [...]
2017 - 9 p. - Published in : Dalton Trans. 46 (2017) 14638-14646 External links: Fulltext; Fulltext; Fulltext; Fulltext

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