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1.
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Measurement of $^{12}$C Fragmentation Cross Sections on C, O, and H in the Energy Range of Interest for Particle Therapy Applications
/ Mattei, I ; Alexandrov, A ; Alunni Solestizi, L ; Ambrosi, G ; Argiro, S ; Bartosik, N ; Battistoni, G ; Belcari, N ; Biondi, S ; Bisogni, M G et al.
In a carbon ion treatment the nuclear fragmentation of both target and beam projectiles impacts on the dose released on the tumor and on the surrounding healthy tissues. Carbon ion fragmentation occurring inside the patient body has to be studied in order to take into account this contribution. [...]
2020 - 14 p.
- Published in : IEEE Trans. Rad. Plasma Med. Sci. 4 (2020) 269-282
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2.
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Biological effectiveness of He-3 and He-4 ion beams for cancer hadrontherapy: a study based on the BIANCA biophysical model
/ Carante, M P (INFN, Pavia ; Pavia U.) ; Embriaco, A (INFN, Pavia) ; Aricò, G (CERN) ; Ferrari, A (Heidelberg U. Hospital ; Gangneung-Wonju Natl. U.) ; Mairani, A (HITS, Heidelberg) ; Mein, S (HITS, Heidelberg) ; Ramos, R (INFN, Pavia) ; Sala, P (INFN, Milan) ; Ballarini, F (INFN, Pavia ; Pavia U.)
While cancer therapy with protons and C-ions is continuously spreading, in the near future patients will be also treated with He-ions which, in comparison to photons, combine the higher precision of protons with the higher relative biological effectiveness (RBE) of C-ions. Similarly to C-ions, also for He-ions the RBE variation along the beam must be known as precisely as possible, especially for active beam delivery systems. [...]
2021 - 14 p.
- Published in : Phys. Med. Biol. 66 (2021) 195009
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3.
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Ion charge separation with new generation of nuclear emulsion films
/ Montesi, M.C. (Naples U. ; INFN, Naples) ; Lauria, A. (Naples U. ; INFN, Naples) ; Alexandrov, A. (INFN, Naples ; Naples U. ; Natl. U. Sci. Tech., Moscow ; Lebedev Inst.) ; Solestizi, L. Alunni (INFN, Perugia ; Perugia U.) ; Giovanni, Ambrosi (INFN, Perugia) ; Argirò, S. (Turin U. ; INFN, Turin) ; Diaz, R. (Havana, CEADEN) ; Bartosik, N. (INFN, Turin) ; Battistoni, G. (INFN, Milan) ; Belcari, N. (Pisa U. ; INFN, Pisa) et al.
In hadron therapy, the accelerated ions, interacting with the body of the patient, cause the fragmentation of both projectile and target nuclei. The fragments interact with the human tissues depositing energy both in the entrance channel and in the volume surrounding the tumor. [...]
2019 - 8 p.
- Published in : Open Physics 17 (2019) 233-240
Fulltext: PDF;
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4.
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RBE predictions by the BIANCA model for $in$ $vitro$ and $in$ $vivo$ irradiations in hadron therapy scenarios
/ Carante, M P (INFN, Pavia) ; Aricò, G (CERN) ; Embriaco, A (INFN, Pavia) ; Ferrari, A (Heidelberg U. Hospital ; Gangneung-Wonju Natl. U.) ; Karger, C P (Unlisted, DE) ; Kozlowska, W (Med. U. of Vienna, Spitalgasse ; CERN) ; Mairani, A (HITS, Heidelberg) ; P Sala, (INFN, Milan) ; Ballarini, F (Pavia U. ; INFN, Pavia)
BIANCA is a two-parameter biophysical model that simulates chromosome aberrations and cell death induced by ionizing radiation, including ions of interest for hadron therapy. In this framework, the model parameters were tuned to produce a radiobiological database describing the survival of V79 cells, chosen as a reference, after irradiation with different monochromatic ion beams [...]
2021 - 9 p.
- Published in : Nuovo Cimento C 43 (2021) 137
Fulltext from publisher: PDF;
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5.
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The FOOT FragmentatiOn Of Target Experiment
/ Alexandrov, Andrey (INFN, Naples) ; Alpat, Behcet (INFN, Perugia) ; Ambrosi, Giovanni (INFN, Perugia) ; Argirò, Stefano (Turin U. ; INFN, Turin) ; Battistoni, Giuseppe (INFN, Milan) ; Bisogni, Maria Giuseppina (Pisa U. ; INFN, Pisa) ; Belcari, Nicola (Pisa U. ; INFN, Pisa) ; Biondi, Silvia (INFN, Bologna ; Bologna U.) ; Bruni, Graziano (INFN, Bologna) ; Camarlinghi, Niccolò (Pisa U. ; INFN, Pisa) et al.
In proton-therapy clinical practice a constant RBE equal to 1.1 is adopted, regardless of the demonstrated RBE variations, which depends on physical and biological parameters. Among other mechanisms, nuclear interactions might influence the proton-RBE due to secondary heavier particles produced by target fragmentation that can significantly contribute to the total dose: an un-wanted and undetermined increase of normal tissues complications probability may occur. [...]
Geneva : CERN, 2019 - 8 p.
- Published in : CERN Proc.: 1 (2019) , pp. 305-312
Fulltext: PDF;
In : 15th International Conference on Nuclear Reaction Mechanisms, Varenna, Italy, 11 - 15 Jun 2018, pp.305-312
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6.
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MONET code: evaluation of the dose in Hadrontherapy
/ Embriaco, A (INFN, Milan) ; Fontana, A (INFN, Pavia) ; Rotondi, A (INFN, Pavia ; Pavia U.)
The energy deposition of Helium ion beams in a water target was investigated
with the development of a new model. The model, called MONET (MOdel of ioN dosE
for Therapy), evaluates the 3D energy deposition distribution for protons in a
water phantom. [...]
Geneva : CERN, 2019 - 6 p.
- Published in : CERN Proc.: 1 (2019) , pp. 327-332
Fulltext: PDF;
In : 15th International Conference on Nuclear Reaction Mechanisms, Varenna, Italy, 11 - 15 Jun 2018, pp.327-332
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7.
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A model for the accurate computation of the lateral scattering of protons in water
/ Bellinzona, EV (Pavia U. ; INFN, Pavia ; Munich U.) ; Ciocca, M (CNAO, Milan) ; Embriaco, A (Pavia U. ; INFN, Pavia) ; Ferrari, A (CERN) ; Fontana, A (Munich U.) ; Mairani, A (CNAO, Milan) ; Parodi, K (Munich U. ; HITS, Heidelberg) ; Rotondi, A (Pavia U. ; INFN, Pavia) ; Sala, P (INFN, Milan) ; Tessonnier, T (Heidelberg U. Hospital)
A pencil beam model for the calculation of the lateral scattering in water of protons for any therapeutic energy and depth is presented. It is based on the full Molière theory, taking into account the energy loss and the effects of mixtures and compounds. [...]
2016 - 17 p.
- Published in : Phys. Med. Biol. 61 (2016) N102-117
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8.
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An analytical solution to lateral dose prediction in Hadrontherapy
/ Bellinzona, E V (Pavia U., Dept. Fis. 'A. Volta' ; INFN, Pavia ; Munich U.) ; Ciocca, M (CNAO, Milan) ; Embriaco, A (Pavia U., Dept. Fis. 'A. Volta' ; INFN, Pavia) ; Ferrari, A (CERN) ; Fontana, A (INFN, Pavia) ; Mairani, A (CNAO, Milan ; HITS, Heidelberg) ; Parodi, K (Munich U. ; HITS, Heidelberg) ; Rotondi, A (Pavia U., Dept. Fis. 'A. Volta' ; INFN, Pavia) ; Sala, P (INFN, Milan) ; Tessonnier, T (HITS, Heidelberg)
Geneva : CERN, 2015
Published version from CERN: PDF;
In : 14th International Conference on Nuclear Reaction Mechanisms, Villa Monastero, Varenna, Italy, 15 - 19 Jun 2015, pp.347
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