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1.
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Demonstration and characterisation of a novel dual-scattering system for very high energy electrons
/ Robertson, C (JAI, UK ; Unlisted, UK ; Newcastle upon Tyne U. ; CERN) ; Corsini, R (CERN) ; Farabolini, W (CERN) ; Gerbershagen, A (U. Med. Ctr. Groningen, Groningen) ; Korysko, P (JAI, UK ; CERN) ; Latina, A (CERN) ; Malyzhenkov, A (CERN ; Unlisted, CH) ; Dosanjh, M (JAI, UK ; CERN)
This article describes the design and implementation of the first known prototype of a dual-scattering system for the delivery of a uniform VHEE beam with transverse dimensions suitable for pre-clinical and potential future clinical use. The results presented in this article are the first experimental characterisation of beam flattening with dual-scattering foils in the VHEE regime, confirmed with both profile measurements with a YAG screen and radiochromic EBT3 films. [...]
2025 - 12 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 1082 (2026) 170943
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2.
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Dual-scattering foil installation at CLEAR
/ Robertson, Cameron (Oxford U.) ; Aksoy, Avni (Ankara U.) ; Bateman, Joseph (Oxford U.) ; Corsini, Roberto (CERN) ; Dosanjh, Manjit (CERN) ; Farabolini, Wilfrid (CERN) ; Gerbershagen, Alexander (Groningen U.) ; Korysko, Pierre (Oxford U.) ; Latina, Andrea (CERN) ; Malyzhenkov, Alexander (CERN) et al.
The CLEAR facility at CERN allows users to receive an electron beam with energy up to 200 MeV, allowing flexibility in intensity, beam size and bunch structures. Separate from the main CERN accelerator complex, it is capable of hosting numerous experiments with rapid installations at two test stands.It would be highly desirable for many applications, but particularly those of a medical nature, to be able to provide a ‘flat’ beam at CLEAR, with a uniform intensity distribution over a significant component of its transverse dimensions. [...]
2023 - 4 p.
- Published in : JACoW IPAC 2023 (2023) THPM073
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.THPM073
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3.
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The CLEAR user facility: a review of the experimental methods and future plans
/ Korysko, Pierre (Oxford U. ; CERN) ; Malyzhenkov, Alexander (CERN) ; Aksoy, Avni (CERN) ; Robertson, Cameron (Oxford U.) ; Bateman, Joseph (Oxford U.) ; Sjobak, Kyrre (Oslo U.) ; Dosanjh, Manjit (Oxford U.) ; Corsini, Roberto (CERN) ; Rieker, Vilde (CERN) ; Farabolini, Wilfrid (CERN)
The CERN Linear Accelerator for Research (CLEAR) is a test facility delivering an electron beam in the 30-220 MeV energy range to a diverse user community. In 2022, several hardware and software upgrades were done to the main installation, and procedures and methods were developed to address specific user requirements, including a further extension of the beam parameter ranges. [...]
2023 - 4 p.
- Published in : JACoW IPAC 2023 (2023) MOPL141
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.MOPL141
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4.
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VHEE and ultra high dose rate radiotherapy studies in the CLEAR user facility
/ Korysko, Pierre (Oxford U. ; CERN) ; Malyzhenkov, Alexander (CERN) ; Robertson, Cameron (Oxford U.) ; Bateman, Joseph (Oxford U.) ; Dosanjh, Manjit (Oxford U.) ; Corsini, Roberto (CERN) ; Rieker, Vilde (CERN) ; Farabolini, Wilfrid (CERN)
Given the current availability of high-gradient accelerator technology for cost effective and compact electron LINACs in the 100-200 MeV energy range, using Very High Energy Electron (VHEE) radiotherapy (RT) for cancer treatment recently gained a lot of interest. The Ultra High Dose Rate (UHDR) or FLASH dose regime, in which cancerous cells are damaged while healthy tissues are largely spared is one of the main topics studied. [...]
2023 - 4 p.
- Published in : JACoW IPAC 2023 (2023) THPM078
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.THPM078
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5.
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Radiochromic Film Dosimetry for VHEE and UHDR: Considerations for the CLEAR Facility and Comparisons with Alanine, RPL and Dosimetry Phantoms
/ Rieker, V.F. (CERN ; Oslo U.) ; Bateman, J.J. (Oxford U.) ; Wroe, L.M. (CERN) ; Caloz, M. (Unlisted, CH) ; Grilj, V. (Unlisted, CH) ; Aguiar, Y.Q. (CERN) ; Schüller, A. (Braunschweig, Phys. Tech. Bund.) ; Bailat, C. (Unlisted, CH) ; Farabolini, W. (CERN) ; Gilardi, A. (CERN) et al.
Radiochromic films (RCFs) offer valuable two-dimensional dosimetry capabilities with a conceptually simple operating principle that requires minimal investment, making them particularly suitable for very high energy electron (VHEE) FLASH dosimetry where dosimetry standards are currently lacking. [...]
arXiv:2506.16837.
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33.
Fulltext
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6.
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Access to diagnostic imaging and radiotherapy technologies for patients with cancer in the Baltic countries, eastern Europe, central Asia, and the Caucasus: a comprehensive analysis
/ Dosanjh, Manjit (Oxford U. ; Unlisted, US) ; Gershan, Vesna (IAEA, Vienna) ; Wendling, Eugenia C (Unlisted, US) ; Khader, Jamal S (Unlisted, JO) ; Ige, Taofeeq A (Unlisted, NG) ; Ristova, Mimoza (Skopje U.) ; Hugtenburg, Richard (Swansea U. (main)) ; Georgieva, Petya (CERN) ; Coleman, C Norman (Unlisted, US) ; Pistenmaa, David A (Unlisted, US) et al.
Only 10–40% of patients with cancer in low-income and middle-income countries were able to access
curative or palliative radiotherapy in 2015. We aimed to assess the current status of diagnostic imaging and
radiotherapy services in the Baltic countries, eastern Europe, central Asia, and the Caucasus by collecting and
analysing local data..
2024 - 9 p.
- Published in : Lancet Oncology 25 (2024) 1487-1495
publication: PDF;
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7.
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Radiotherapy and theranostics: a Lancet Oncology Commission
/ Abdel-Wahab, May ; Giammarile, Francesco ; Carrara, Mauro ; Paez, Diana ; Hricak, Hedvig ; Ayati, Nayyereh ; Li, Jing Jing ; Mueller, Malina ; Aggarwal, Ajay ; Al-Ibraheem, Akram et al.
Following on from the 2015 Lancet Oncology Commission on expanding global access to radiotherapy, Radiotherapy and theranostics: a Lancet Oncology Commission was created to assess the access and availability of radiotherapy to date and to address the important issue of access to the promising field of theranostics at a global level. A marked disparity in the availability of radiotherapy machines between high-income countries and low-income and middle-income countries (LMICs) has been identified previously and remains a major problem. [...]
2024
- Published in : Lancet Oncology 25 (2024) e545-e580
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9.
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Spatially fractionated radiotherapy with very high energy electron pencil beam scanning
/ Fischer, Jade (Victoria U.) ; Hart, Alexander (Victoria U.) ; Bedriová, Nicole (Zilina U.) ; Krim, Deae-eddine (Victoria U.) ; Clements, Nathan (Victoria U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U.) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (Oslo U.) ; Corsini, Roberto (CERN) et al.
Objective. To evaluate spatially fractionated radiation therapy (SFRT) for very-high-energy electrons (VHEEs) delivered with pencil beam scanning. [...]
2024 - 12 p.
- Published in : Phys. Med. Biol. 70 (2025) 015011
Fulltext: PDF;
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10.
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Medical activities in CLEAR: studies towards radiotherapy using Very High Energy Electrons (VHEE) in the FLASH regime
/ Corsini, Roberto (CERN) ; Malyzhenkov, Alexander (CERN) ; Gilardi, Antonio (Naples U. ; INFN, Naples) ; Aksoy, Avni (CERN) ; Robertson, Cameron (Oxford U.) ; Bateman, Joseph (Oxford U.) ; Dosanjh, Manjit (CERN) ; Korysko, Pierre (Oxford U.) ; Rieker, Vilde (CERN) ; Farabolini, Wilfrid (CERN)
Given the present availability of high-gradient accelerator technology for compact and cost-effective electron linacs in the 100-200 MeV energy range, the interest for Very High Energy Electron (VHEE) radiotherapy (RT) for cancer treatment recently reached an all-time high. Particular significance is assumed by the Ultra-High Dose Rate (UHDR) regime where the so-called FLASH biological effect takes place, in which cancer cells are damaged while healthy tissue is largely spared. [...]
2024 - 4 p.
- Published in : JACoW LINAC 2024 (2024) THPB018
Fulltext: PDF;
In : 32nd Linear Accelerator Conference (LINAC 2024), Chicago, Illinois, United States, 25 - 30 Aug 2024, pp.THPB018
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