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Quantification of trace $^{227}$Ac and other radionuclidic impurities in mass-separated $^{225}$Ac samples produced at CERN-MEDICIS / Johnson, Jake D (Leuven U.) ; Bernerd, Cyril (Leuven U. ; CERN) ; Bruchertseifer, Frank (Unlisted, DE) ; Cocolios, Thomas E (Leuven U.) ; Deseyn, Marie (Leuven U.) ; Duchemin, Charlotte (Leuven U. ; CERN) ; Heines, Michael (Leuven U.) ; Keppens, Max (Leuven U.) ; Lambert, Laura (CERN) ; Meurrens, Nathan (Leuven U.) et al.
$^{225}$Ac is a promising candidate medical radionuclide for targeted alpha therapy of advanced stage cancers. One of the main production pathways is the high-energy proton spallation of thorium-based targets, that requires an efficient, nuclide-selective separation method to recover $^{225}$Ac from hundreds of co-produced spallation and fission products. [...]
2025 - 14 p. - Published in : Sci. Rep. 15 (2025) 23563 Fulltext: PDF;

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Resonant laser ionization and mass separation of $^{225}$Ac / Johnson, Jake D (Leuven U.) ; Heines, Michael (Leuven U.) ; Bruchertseifer, Frank (Geel, JRC) ; Chevallay, Eric (CERN) ; Cocolios, Thomas E (Leuven U.) ; Dockx, Kristof (Leuven U.) ; Duchemin, Charlotte (Leuven U. ; CERN) ; Heinitz, Stephan (SCK-CEN, Mol) ; Heinke, Reinhard (Leuven U. ; CERN) ; Hurier, Sophie (Leuven U. ; SCK-CEN, Mol) et al.
$^{225}$Ac is a radio-isotope that can be linked to biological vector molecules to treat certain distributed cancers using targeted alpha therapy. However, developing $^{225}$Ac-labelled radiopharmaceuticals remains a challenge due to the supply shortage of pure $^{225}$Ac itself. [...]
2023 - 11 p. - Published in : Sci. Rep. 13 (2023) 1347 Fulltext: PDF;

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CERN-MEDICIS: A Review Since Commissioning in 2017 / MEDICIS Collaboration
The CERN-MEDICIS (MEDical Isotopes Collected from ISolde) facility has delivered its first radioactive ion beam at CERN (Switzerland) in December 2017 to support the research and development in nuclear medicine using non-conventional radionuclides. Since then, fourteen institutes, including CERN, have joined the collaboration to drive the scientific program of this unique installation and evaluate the needs of the community to improve the research in imaging, diagnostics, radiation therapy and personalized medicine. [...]
2021 - 11 p. - Published in : Frontiers in Medicine 8 (2021) 693682 Fulltext: PDF;

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Towards reliable production of 225Ac for medical applications: Systematic analysis of the production of Fr, Ra and Ac beams. / Dockx, Kristof (KU Leuven, Belgium) ; Bruchertseifer, Frank (JRC-ITU, Germany) ; Cocolios, Thomas Elias (KU Leuven, Belgium) ; Dierckx, Marc (SCK-CEN, Belgium) ; Fedosseev, Valentin N (CERN, Switzerland) ; Fenwick, Andrew (NPL, United Kingdom) ; Giles, Tim (CERN, Switzerland) ; Houngbo, Donald (SCK-CEN, Belgium) ; Judge, Steven (NPL, United Kingdom) ; Keightley, John (NPL, United Kingdom) et al.
CERN-INTC-2017-016 ; INTC-P-498. - 2017.
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Radium and Francium beam tests to produce 225Ac/ 213Bi generators at CERN-MEDICIS / Bruchertseifer, Frank (JRC-ITU, Karlsruhe) ; Morgenstern, Alfred (JRC-ITU, Karlsruhe) ; Martinez, Yisel (KULeuven, Leuven & CERN, Geneva) ; Cocolios, Thomas (KULeuven, Leuven) ; Stora, Thierry (CERN, Geneva)
CERN-INTC-2015-052 ; INTC-I-164. - 2015.
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