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CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications
/ Whitmore, L (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech. ; Texas U., Houston) ; Mackay, R I (Manchester U.) ; van Herk, M (Manchester U.) ; Korysko, P (Oxford U. ; CERN) ; Farabolini, W (CERN) ; Malyzhenkov, A (CERN) ; Corsini, R (CERN) ; Jones, R M (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.)
Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due to their highly penetrating nature and their applicability as a modality for FLASH (ultra-high dose-rate) radiotherapy. The dose distributions due to VHEE need to be optimised; one option is through the use of quadrupole magnets to focus the beam, reducing the dose to healthy tissue and allowing for targeted dose delivery at conventional or FLASH dose-rates. [...]
2024 - 15 p.
- Published in : Sci. Rep. 14 (2024) 11120
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Beam-based commissioning of a novel X-band transverse deflection structure with variable polarization
/ González Caminal, P (DESY) ; Christie, F (DESY) ; D'Arcy, R (DESY) ; Jaster-Merz, S M (DESY) ; Assmann, R (DESY) ; Burkart, F (DESY) ; Conrad, B (DESY) ; Dinter, H (DESY) ; Foese, M (DESY) ; Herrmann, J (DESY) et al.
Longitudinal electron-beam diagnostics play a critical role in the operation and control of x-ray free-electron lasers, which rely on parameters such as the current profile, the longitudinal phase space, or the slice emittance of the particle distribution. On the one hand, the femtosecond-scale electron bunches produced at these facilities impose stringent requirements on the resolution achievable with the diagnostics. [...]
2024 - 19 p.
- Published in : Phys. Rev. Accel. Beams 27 (2024) 032801
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3.
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Determination of the Terbium-152 half-life from mass-separated samples from CERN-ISOLDE and assessment of the radionuclide purity
/ Collins, S M (Teddington, Natl. Phys. Lab ; U. Surrey (main)) ; Ko¨ster, U (Laue-Langevin Inst.) ; Robinson, A P (Teddington, Natl. Phys. Lab ; U. Manchester (main) ; Manchester U.) ; Ivanov, P (Teddington, Natl. Phys. Lab) ; Cocolios, T E (Leuven U.) ; Russell, B (Teddington, Natl. Phys. Lab) ; Fenwick, A J (Teddington, Natl. Phys. Lab) ; Bernerd, C (Leuven U. ; CERN) ; Stegemann, S (Leuven U.) ; Johnston, K (CERN) et al.
Terbium-152 is one of four terbium radioisotopes that together form a potential theranostic toolbox for the personalised treatment of tumours. As 152 Tb decay by positron emission it can be utilised for diagnostics by positron emission tomography. [...]
2023 - 16 p.
- Published in : Appl. Radiat. Isot. 202 (2023) 111044
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Half-life determination of $^{155}$Tb from mass-separated samples produced at CERN-MEDICIS
/ Collins, S M (Teddington, Natl. Phys. Lab ; Surrey U.) ; Robinson, A P (Teddington, Natl. Phys. Lab) ; Ivanov, P (Teddington, Natl. Phys. Lab) ; Köster, U (Laue-Langevin Inst.) ; Cocolios, T E (Leuven U.) ; Russell, B (Teddington, Natl. Phys. Lab) ; Webster, B (Teddington, Natl. Phys. Lab ; Surrey U.) ; Fenwick, A J (Teddington, Natl. Phys. Lab) ; Duchemin, C (Leuven U. ; CERN) ; Ramos, J P (Leuven U. ; CERN ; Belgian Ceramic Res. Ctr., Mons) et al.
Terbium-155 has been identified for its potential for single-photon emission computed tomography (SPECT) in nuclear medicine. For activity measurements, an accurate and precise half-life of this radionuclide is required. [...]
2022 - 11 p.
- Published in : Appl. Radiat. Isot. 190 (2022) 110480
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5.
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The PolariX-TDS Project: Bead-Pull Measurements and High-Power Test on the Prototype
/ Craievich, Paolo (PSI, Villigen) ; Aßmann, Ralph (DESY) ; Bopp, Markus (PSI, Villigen) ; Braun, Hans-Heinrich (PSI, Villigen) ; Catalán Lasheras, Nuria (CERN) ; Christie, Florian (DESY) ; Citterio, Alessandro (PSI, Villigen) ; D'Arcy, Richard (DESY) ; Dorda, Ulrich (DESY) ; Foese, Manon (DESY) et al.
A collaboration between DESY, PSI and CERN has been established to develop and build an advanced modular X- band transverse deflection structure (TDS) system with the new feature of providing variable polarization of the deflecting force. The prototype of the novel X-band TDS, the Polarizable X-band (PolariX) TDS, was fabricated at PSI following the high-precision tuning-free production process developed for the C-band Linac of the SwissFEL project. [...]
2019 - 4 p.
- Published in : 10.18429/JACoW-FEL2019-WEP036
Fulltext: PDF;
In : 39th International Free Electron Laser Conference, Hamburg, Germany, 26 - 30 Aug 2019, pp.WEP036
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6.
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Experimental demonstration of novel beam characterization using a polarizable X-band transverse deflection structure
/ Marchetti, B (DESY ; European XFEL, Hamburg) ; Grudiev, A (CERN) ; Craievich, P (PSI, Villigen) ; Assmann, R (DESY) ; Braun, H H (PSI, Villigen) ; Catalan Lasheras, N (CERN) ; Christie, F (DESY) ; D'Arcy, R (DESY) ; Fortunati, R (PSI, Villigen) ; Ganter, R (PSI, Villigen) et al.
The PolariX TDS (Polarizable X-Band Transverse Deflection Structure) is an innovative TDS-design operating in the X-band frequency-range. The design gives full control of the streaking plane, which can be tuned in order to characterize the projections of the beam distribution onto arbitrary transverse axes. [...]
2021 - 14 p.
- Published in : Sci. Rep. 11 (2021) 3560
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7.
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Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage
/ Small, K L (Manchester U. ; Daresbury) ; Henthorn, N T (Manchester U. ; Unlisted, GB) ; Angal-Kalinin, D (Manchester U. ; Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) ; Chadwick, A L (Manchester U. ; Unlisted, GB) ; Santina, E (Manchester U. ; Unlisted, GB) ; Aitkenhead, A (Manchester U. ; Unlisted, GB) ; Kirkby, K J (Manchester U. ; Unlisted, GB) ; Smith, R J (Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) ; Surman, M (Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) ; Jones, J (Daresbury ; Cockcroft Inst. Accel. Sci. Tech.) et al.
This paper presents the first plasmid DNA irradiations carried out with Very High Energy Electrons (VHEE) over 100–200 MeV at the CLEAR user facility at CERN to determine the Relative Biological Effectiveness (RBE) of VHEE. DNA damage yields were measured in dry and aqueous environments to determine that ~ 99% of total DNA breaks were caused by indirect effects, consistent with other published measurements for protons and photons. [...]
2021 - 12 p.
- Published in : Sci. Rep. 11 (2021) 3341
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8.
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Novel $X$ -band transverse deflection structure with variable polarization
/ Craievich, P (PSI, Villigen) ; Bopp, M (PSI, Villigen) ; Braun, H H (PSI, Villigen) ; Citterio, A (PSI, Villigen) ; Fortunati, R (PSI, Villigen) ; Ganter, R (PSI, Villigen) ; Kleeb, T (PSI, Villigen) ; Marcellini, F (PSI, Villigen) ; Pedrozzi, M (PSI, Villigen) ; Prat, E (PSI, Villigen) et al.
A collaboration between DESY, PSI and CERN has developed and built an advanced modular X-band transverse deflection structure (TDS) system with the new feature of providing variable polarization of the deflecting force. The prototype of the novel X-band TDS, the polarizable $X$-band (PolariX) TDS, was fabricated at PSI following the high-precision tuning-free production process developed for the C-band Linac of the SwissFEL project. [...]
2020 - 22 p.
- Published in : Phys. Rev. Accel. Beams 23 (2020) 112001
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9.
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Sub-Femtosecond Time-Resolved Measurements Based on a Variable Polarization X-Band Transverse Deflecting Structures for SwissFEL
/ Craievich, Paolo (PSI, Villigen) ; Aßmann, Ralph (DESY) ; Bopp, Markus (PSI, Villigen) ; Braun, Hans-Heinrich (PSI, Villigen) ; Catalán Lasheras, Nuria (CERN) ; Christie, Florian (DESY) ; D'Arcy, Richard (DESY) ; Ganter, Romain (PSI, Villigen) ; Grudiev, Alexej (CERN) ; Marchetti, Barbara (DESY) et al.
The SwissFEL project, under commissioning at the Paul Scherrer Institut (PSI), will produce FEL radiation for soft and hard X-rays with pulse durations ranging from a few to several tens of femtoseconds. A collaboration between DESY, PSI and CERN has been established with the aim of developing and building an advanced X-Band transverse deflector structure (TDS) with the new feature of providing variable polarization of the deflecting force. [...]
2018 - 4 p.
- Published in : 10.18429/JACoW-FEL2017-WEP040
Fulltext: PDF;
In : 38th International Free Electron Laser Conference, Santa Fe, New Mexico, USA, 20 - 25 Aug 2017, pp.WEP040
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10.
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Status of the Polarix-TDS Project
/ Craievich, Paolo (PSI, Villigen) ; Aßmann, Ralph (DESY) ; Bopp, Markus (PSI, Villigen) ; Braun, Hans-Heinrich (PSI, Villigen) ; Catalán Lasheras, Nuria (CERN) ; Christie, Florian (DESY) ; D'Arcy, Richard (DESY) ; Dorda, Ulrich (DESY) ; Foese, Manon (DESY) ; Ganter, Romain (PSI, Villigen) et al.
A collaboration between DESY, PSI and CERN has been established to develop and build an advanced modular X-band transverse deflection structure (TDS) system with the new feature of providing variable polarization of the deflecting force. This innovative CERN design requires very high manufacturing precision to guarantee highest azimuthal symmetry of the structure to avoid the deterioration of the polarization of the streaking field. [...]
CERN-ACC-2018-157.-
2018 - 4 p.
- Published in : 10.18429/JACoW-IPAC2018-THPAL068
Fulltext: PDF;
In : 9th International Particle Accelerator Conference, Vancouver, Canada, 29 Apr - 4 May 2018, pp.THPAL068
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