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1.
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Measurement of $^{12}$C Fragmentation Cross Sections on C, O, and H in the Energy Range of Interest for Particle Therapy Applications
/ Mattei, I ; Alexandrov, A ; Alunni Solestizi, L ; Ambrosi, G ; Argiro, S ; Bartosik, N ; Battistoni, G ; Belcari, N ; Biondi, S ; Bisogni, M G et al.
In a carbon ion treatment the nuclear fragmentation of both target and beam projectiles impacts on the dose released on the tumor and on the surrounding healthy tissues. Carbon ion fragmentation occurring inside the patient body has to be studied in order to take into account this contribution. [...]
2020 - 14 p.
- Published in : IEEE Trans. Rad. Plasma Med. Sci. 4 (2020) 269-282
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2.
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Ion charge separation with new generation of nuclear emulsion films
/ Montesi, M.C. (Naples U. ; INFN, Naples) ; Lauria, A. (Naples U. ; INFN, Naples) ; Alexandrov, A. (INFN, Naples ; Naples U. ; Natl. U. Sci. Tech., Moscow ; Lebedev Inst.) ; Solestizi, L. Alunni (INFN, Perugia ; Perugia U.) ; Giovanni, Ambrosi (INFN, Perugia) ; Argirò, S. (Turin U. ; INFN, Turin) ; Diaz, R. (Havana, CEADEN) ; Bartosik, N. (INFN, Turin) ; Battistoni, G. (INFN, Milan) ; Belcari, N. (Pisa U. ; INFN, Pisa) et al.
In hadron therapy, the accelerated ions, interacting with the body of the patient, cause the fragmentation of both projectile and target nuclei. The fragments interact with the human tissues depositing energy both in the entrance channel and in the volume surrounding the tumor. [...]
2019 - 8 p.
- Published in : Open Physics 17 (2019) 233-240
Fulltext: PDF;
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3.
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Monitoring Proton Therapy Through in-Beam PET: An Experimental Phantom Study
/ Topi, A (INFN, Pisa) ; Muraro, S (INFN, Pisa) ; Battistoni, G (INFN, Milan) ; Belcari, N (INFN, Pisa ; Pisa U.) ; Bisogni, M G (INFN, Pisa ; Pisa U.) ; Camarlinghi, N (INFN, Pisa ; Pisa U.) ; Del Guerra, A (INFN, Pisa ; Pisa U.) ; Ferrari, A (CERN) ; Kopec, R (Cracow, INP) ; Kraan, A C (INFN, Pisa) et al.
In this paper, we investigate the use of a positron
emission tomography (PET) system to monitor the proton therapy. The monitoring procedure is based on the comparison
between the β+ activity generated in the irradiated volume during the treatment, with the β+ activity distribution obtained
with Monte Carlo (MC) simulation. [...]
2020 - 8 p.
- Published in : IEEE Trans. Rad. Plasma Med. Sci. 4 (2020) 194-201
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4.
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Low statistics positron activity reconstruction methods for proton therapy
/ Muraro, S (Pisa U. ; INFN, Pisa) ; Camarlinghi, N (Pisa U. ; INFN, Pisa) ; Battistoni, G (INFN, Milan) ; Belcari, N (Pisa U. ; INFN, Pisa) ; Bisogni, M G (INFN, Pisa ; Pisa U.) ; Cristoforetti, L (Unlisted, IT) ; Del Guerra, A (Pisa U. ; INFN, Pisa) ; Ferrari, A (CERN) ; Fracchiolla, F (Unlisted, IT) ; Kraan, A (Pisa U. ; INFN, Pisa) et al.
Positron emission tomography (PET) is one of the most mature techniques for monitoring in ion beam therapy. PET allows to reconstruct the β$^{+}$ activity generated in the patient by the nuclear interaction of the ions. [...]
2019 - 2 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 936 (2019) 52-53
In : Frontier Detectors for Frontier Physics: XIV Pisa Meeting on Advanced Detectors, La Biodola, Isola D'elba, Italy, 27 May - 2 Jun 2018, pp.52-53
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5.
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The FOOT FragmentatiOn Of Target Experiment
/ Alexandrov, Andrey (INFN, Naples) ; Alpat, Behcet (INFN, Perugia) ; Ambrosi, Giovanni (INFN, Perugia) ; Argirò, Stefano (Turin U. ; INFN, Turin) ; Battistoni, Giuseppe (INFN, Milan) ; Bisogni, Maria Giuseppina (Pisa U. ; INFN, Pisa) ; Belcari, Nicola (Pisa U. ; INFN, Pisa) ; Biondi, Silvia (INFN, Bologna ; Bologna U.) ; Bruni, Graziano (INFN, Bologna) ; Camarlinghi, Niccolò (Pisa U. ; INFN, Pisa) et al.
In proton-therapy clinical practice a constant RBE equal to 1.1 is adopted, regardless of the demonstrated RBE variations, which depends on physical and biological parameters. Among other mechanisms, nuclear interactions might influence the proton-RBE due to secondary heavier particles produced by target fragmentation that can significantly contribute to the total dose: an un-wanted and undetermined increase of normal tissues complications probability may occur. [...]
Geneva : CERN, 2019 - 8 p.
- Published in : CERN Proc.: 1 (2019) , pp. 305-312
Fulltext: PDF;
In : 15th International Conference on Nuclear Reaction Mechanisms, Varenna, Italy, 11 - 15 Jun 2018, pp.305-312
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6.
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Proton therapy treatment monitoring with the DoPET system: activity range, positron emitters evaluation and comparison with Monte Carlo predictions
/ Muraro, S (Pisa U. ; INFN, Pisa) ; Battistoni, G (INFN, Milan) ; Belcari, N (Pisa U. ; INFN, Pisa) ; Bisogni, M G (Pisa U. ; INFN, Pisa) ; Camarlinghi, N (Pisa U. ; INFN, Pisa) ; Cristoforetti, L (Trento Hospital, Trento) ; Guerra, A Del (Pisa U. ; INFN, Pisa) ; Ferrari, A (CERN) ; Fracchiolla, F (Trento Hospital, Trento) ; Morrocchi, M (Pisa U. ; INFN, Pisa) et al.
Ion beam irradiations can deliver conformal dose distributions minimizing damage to healthy tissues thanks to their characteristic dose profiles. Nevertheless, the location of the Bragg peak can be affected by different sources of range uncertainties: a critical issue is the treatment verification. [...]
2017 - 10 p.
- Published in : JINST 12 (2017) C12026
In : 19th International Workshop on Radiation Imaging Detectors, Krakow, Poland, 2 - 6 Jul 2017, pp.C12026
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7.
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The Application of the Monte Carlo Code FLUKA in Radiation Protection Studies for the Large Hadron Collider
/ Battistoni, Giuseppe (INFN, Milan) ; Broggi, Francesco (INFN, Milan) ; Brugger, Markus (CERN) ; Campanella, Mauro (INFN, Milan) ; Carboni, Massimo (INFN, Legnaro) ; Empl, Anton (Houston U.) ; Fassò, Alberto (Jefferson Lab) ; Gadioli, Ettore (INFN, Milan) ; Cerutti, Francesco (CERN) ; Ferrari, Alfredo (CERN) et al.
2011
- Published in : Prog. Nucl. Sci. Tech. 2 (2011) 358-364
Fulltext: PDF; External link: Fulltext
In : Joint International Conference of the 7th Supercomputing in Nuclear Application and the 3rd Monte Carlo, Tokyo, Japan, 17 - 21 Oct 2010, pp.358-364
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8.
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Measurements of secondary particles emitted by $^{12}$C, $^{4}$He and $^{16}$O ion beams in view of innovative dose profiling technique in Particle Therapy
/ Rucinski, A (INFN, Rome ; U. Rome La Sapienza (main)) ; Battistoni, G (INFN, Milan) ; Collamati, F (Rome U. ; INFN, Rome) ; De Lucia, E (Frascati) ; Faccini, R (Rome U. ; INFN, Rome) ; Marafini, M (Rome U. ; INFN, Rome) ; Mattei, I (INFN, Milan) ; Muraro, S (INFN, Milan) ; Paramatti, R (INFN, Rome) ; Patera, V (INFN, Rome ; U. Rome La Sapienza (main) ; Enrico Fermi Ctr., Rome) et al.
Geneva : CERN, 2015
Published version from CERN: PDF;
In : 14th International Conference on Nuclear Reaction Mechanisms, Villa Monastero, Varenna, Italy, 15 - 19 Jun 2015, pp.355
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9.
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Charged and neutral particles production from an 80 MeV/u 12C ion beam on a PMMA target
/ Agodi, A (INFN, LNS) ; Battistoni, G (INFN, Milan) ; Bellini, F (Rome U. ; INFN, Rome) ; Cirrone, G A P (INFN, LNS) ; Collamati, F (Rome U. ; INFN, Rome) ; Cuttone, G (INFN, LNS) ; De Lucia, E (Frascati) ; De Napoli, M (INFN, LNS) ; Di Domenico, A (Rome U. ; INFN, Rome) ; Faccini, R (Rome U. ; INFN, Rome) et al.
2012
Fulltext: PDF;
In : 13th international conference on nuclear reaction mechanisms, Villa Monastero, Varenna, Italy, 11 - 15 Jun 2012, pp.453
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10.
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Applications of FLUKA Monte Carlo code for nuclear and accelerator physics
/ Battistoni, Giuseppe (INFN, Milan ; Milan U.) ; Broggi, Francesco (INFN, Milan ; Milan U.) ; Brugger, Markus (CERN) ; Campanella, Mauro (INFN, Milan ; Milan U.) ; Carboni, Massimo (INFN, Legnaro) ; Empl, Anton (Houston U.) ; Fasso, Alberto (SLAC) ; Gadioli, Ettore (INFN, Milan ; Milan U.) ; Cerutti, Francesco (CERN) ; Ferrari, Alfredo (CERN) et al.
FLUKA is a general purpose Monte Carlo code capable of handling all radiation components from thermal energies (for neutrons) or 1keV (for all other particles) to cosmic ray energies and can be applied in many different fields. Presently the code is maintained on Linux. [...]
2011 - 7 p.
- Published in : Nucl. Instrum. Methods Phys. Res., B 269 (2011) 2850-2856
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