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1.
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Active dosimetry for VHEE FLASH radiotherapy using beam profile monitors and charge measurements
/ Rieker, Vilde F (CERN ; Oslo U.) ; Corsini, Roberto (CERN) ; Stapnes, Steinar (CERN) ; Adli, Erik (Oslo U.) ; Farabolini, Wilfrid (CERN) ; Grilj, Veljko (SUBATECH, Nantes) ; Sjobak, Kyrre N (Oslo U.) ; Wroe, Laurence M (CERN) ; Aksoy, Avni (CERN ; Ankara U.) ; Robertson, Cameron S (Oxford U.) et al.
The discovery of the FLASH effect has revealed a high potential for treating cancer more efficiently by sparing
healthy tissue. The surge in related medical research activities over the last couple of years has triggered a
demand for technology with the capability of generating and measuring ionizing radiation at ultra-high doserates (UHDR). [...]
2024 - 12 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 1069 (2024) 169845
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2.
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A Compact Inverse Compton Scattering Source Based on X-band Technology and Cavity-enhanced High Average Power Ultrafast Lasers
/ Latina, Andrea (CERN) ; Cormier, Eric (LP2N, Bordeaux) ; Corsini, Roberto (CERN) ; Dyks, Luke (CERN) ; Granados, Eduardo (CERN) ; Grudiev, Alexej (CERN) ; Mușat, Vlad (CERN) ; Santarelli, Giorgio (LP2N, Bordeaux) ; Stapnes, Steinar (CERN) ; Wang, Ping (CERN) et al.
A high-pulse-current photoinjector followed by a short high-gradient X-band linac and a Fabry-Pérot enhancement cavity are considered as a driver for a compact Inverse Compton Scattering (ICS) source. Using a high-power ultra-short pulse laser operating in burst mode in a Fabry-Pérot enhancement cavity, we show that outcoming photons with a total flux over 10$^{13}$ and energies in the MeV range are achievable. [...]
2024 - 4 p.
- Published in : JACoW FLS 2023 (2024) TH4A2
Fulltext: PDF;
In : ICFA Advanced Beam Dynamics Workshop on Future Light Sources, Lucerne, Switzerland, 28 Aug - 1 Sep 2023, pp.TH4A2
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3.
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Bubble-beam accelerators: breaking the paradigm
/ Malyzhenkov, Alexander (CERN) ; Latina, Andrea (CERN) ; Dyks, Luke (CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN) ; Aksoy, Avni (CERN ; Ankara U.) ; Korysko, Pierre (JAI, UK ; CERN) ; Burrows, Philip (JAI, UK) ; Tranchedone, Lorenzo (JAI, UK ; CERN)
Most particle accelerators utilize beams with a charge density concentrated in the center of the bunch in real 3-dimensional space and the 6-dimensional phase space. In this work, by enhancing the space-charge forces in the photo-cathode injector of the Compact Linear Electron Accelerator for Research (CLEAR) at CERN, we produce electron bunches with a “bubble-like” shape, with a charge density mostly concentrated on the outside shell. [...]
2024 - 4 p.
- Published in : JACoW IPAC 2024 (2024) WEPC03
Fulltext: PDF;
In : 15th International Particle Accelerator Conference (IPAC 2024), Nashville, TN, United States, 19 - 24 May 2024, pp.WEPC03
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4.
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Application of beam-based alignment to the CLEAR facility
/ Aksoy, Avni (Ankara U. ; CERN) ; Malyzhenkov, Alexander (CERN) ; Latina, Andrea (CERN) ; Korysko, Pierre (Oxford U. ; CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN)
The CERN Linear Electron Accelerator for Research (CLEAR) has been operating since 2017 as a user facility providing beams for a large variety of experiments. Its RF photocathode-based linear accelerator can accelerate electrons up to 220 MeV with a bunch charge of 0.1-1.5nC with single or up to 150 bunches per train. [...]
2023 - 4 p.
- Published in : JACoW IPAC 2023 (2023) WEPL025
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.WEPL025
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5.
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Electron beam test facilities for novel applications
/ Angal-Kalinin, Deepa (Daresbury) ; Mueller, Anke-Susanne (KIT, Karlsruhe) ; Burkart, Florian (DESY) ; Jones, James (Daresbury) ; Schuh, Marcel (KIT, Karlsruhe) ; Pompili, Riccardo (INFN, Milan) ; Corsini, Roberto (CERN) ; Pacey, Thomas (Daresbury) ; Li, Xiangkun (DESY, Zeuthen) ; Stephan, Frank (DESY, Zeuthen)
Delivering and tailoring high brightness electron beams for a wide range of novel applications is a challenging task in single pass accelerator test facilities. This paper will review beam dynamics challenges at single pass accelerator test facilities in Europe to generate, transport and tailor low- to medium-energy high brightness electron beams for a range of novel applications..
2023 - 5 p.
- Published in : JACoW IPAC 2023 (2023) MOZG1
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.MOZG1
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6.
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VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint
/ Wanstall, Hannah C (Manchester U. ; Daresbury) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfred (CERN) ; Corsini, Roberto (CERN) ; Bateman, Joseph J (Oxford U., Theor. Phys.) ; Rieker, Vilde (CERN ; Oslo U.) ; Hemming, Abigail (U. Manchester (main)) ; Henthorn, Nicholas T (U. Manchester (main) ; Manchester U.) ; Merchant, Michael J (Manchester U.) ; Santina, Elham (Manchester U.) et al.
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied across several radiation modalities, including photons, protons and clinical energy electrons, however, very little data is available for the effect of FLASH with Very High Energy Electrons (VHEE). [...]
2024 - 13 p.
- Published in : Sci. Rep. 14 (2024) 14803
Fulltext: PDF;
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7.
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Plastic Scintillator Dosimetry of Ultrahigh Dose-Rate 200 MeV Electrons at CLEAR
/ Hart, Alexander (Victoria U.) ; Giguère, Cloé (Laval U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U.) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Esplen, Nolan (Victoria U.) ; Corsini, Roberto (CERN) ; Dosanjh, Manjit (Oxford U.) ; Beaulieu, Luc (Laval U.) et al.
Very-high-energy electron (VHEE) beams with energies greater than 100 MeV may be promising candidates for FLASH radiotherapy due to their favorable dose distributions and accessibility of ultrahigh dose rates (UHDRs). Combining VHEE with the normal tissue-sparing FLASH effect of UHDR radiotherapy could improve patient outcomes. [...]
2024 - 9 p.
- Published in : IEEE Sensors J. 24 (2024) 14229-14237
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8.
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Development of a novel fibre optic beam profile and dose monitor for very high energy electron radiotherapy at ultrahigh dose rates
/ Bateman, Joseph J (JAI, UK) ; Buchanan, Emma (CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN) ; Korysko, Pierre (JAI, UK ; CERN) ; Larsen, Robert Garbrecht (CERN ; Groningen U.) ; Malyzhenkov, Alexander (CERN) ; Ruiz, Iñaki Ortega (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Gerbershagen, Alexander (Groningen U.)
Objective. Very high energy electrons (VHEE) in the range of 50–250 MeV are of interest for treating deep-seated tumours with FLASH radiotherapy (RT). [...]
2024 - 16 p.
- Published in : Phys. Med. Biol. 69 (2024) 085006
Fulltext: PDF;
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9.
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Mini-GRID radiotherapy on the CLEAR very-high-energy electron beamline: collimator optimization, film dosimetry, and Monte Carlo simulations
/ Clements, Nathan (Victoria U.) ; Esplen, Nolan (Victoria U.) ; Bateman, Joseph (Oxford U.) ; Robertson, Cameron (Oxford U.) ; Dosanjh, Manjit (Oxford U. ; CERN) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfrid (CERN) ; Corsini, Roberto (CERN) ; Bazalova-Carter, Magdalena (Victoria U.)
Objective. Spatially-fractionated radiotherapy (SFRT) delivered with a very-high-energy electron (VHEE) beam and a mini-GRID collimator was investigated to achieve synergistic normal tissue-sparing through spatial fractionation and the FLASH effect. [...]
2024 - 17 p.
- Published in : Phys. Med. Biol. 69 (2024) 055003
Fulltext: PDF;
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10.
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Electron beam studies on a beam position monitor based on Cherenkov diffraction radiation
/ Pakuza, Collette (JAI, UK) ; Malyzhenkov, Alexander (CERN) ; Schloegelhofer, Andreas (CERN) ; Aksoy, Avni (CERN) ; Spear, Bethany (JAI, UK) ; Senes, Eugenio (CERN) ; Lasocha, Kacper (CERN) ; Wendt, Manfred (CERN) ; Krupa, Michal (CERN) ; Chritin, Nicolas (CERN) et al.
A beam position monitor based on Cherenkov diffraction radiation (ChDR BPM) is currently under investigation to disentangle the electromagnetic field of an electron bunch from that of a proton bunch travelling together in time and space in the beam-line of the AWAKE plasma acceleration experiment at CERN. The signals from a horizontal pair of ChDR BPM radiators have been studied under a variety of beam conditions at the CLEAR electron beam test facility. [...]
2023 - 4 p.
- Published in : JACoW IPAC 2023 (2023) THPL146
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.THPL146
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