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1.
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Dosimetric validation of Monte Carlo and analytical dose engines with raster-scanning $^1$H, $^4$He, $^{12}$C, and $^{16}$O ion-beams using an anthropomorphic phantom
/ Mein, Stewart (NCRO, Heidelberg ; Heidelberg U. Hospital ; DKFZ, Heidelberg) ; Kopp, Benedikt (Heidelberg U. Hospital ; Heidelberg U. ; DKFZ, Heidelberg) ; Tessonnier, Thomas (Centre Francois Baclesse, Caen) ; Ackermann, Benjamin (Heidelberg U. Hospital) ; Ecker, Swantje (Heidelberg U. Hospital) ; Bauer, Julia (Heidelberg U. Hospital) ; Choi, Kyungdon (CNAO, Pavia) ; Aricò, Giulia (CERN) ; Ferrari, Alfredo (CERN) ; Haberer, Thomas (Heidelberg U. Hospital) et al.
With high-precision radiotherapy on the rise towards mainstream healthcare, comprehensive validation procedures are essential, especially as more sophisticated technologies emerge. In preparation for the upcoming
translation of novel ions, case-/disease-specific ion-beam selection and advanced multi-particle treatment
modalities at the Heidelberg Ion-beam Therapy Center (HIT), we quantify the accuracy limits in particle therapy
treatment planning under complex heterogeneous conditions for the four ions ($^1$H, $^4$He, $^{12}$C, $^{16}$O) using a Monte
Carlo Treatment Planning platform (MCTP), an independent GPU-accelerated analytical dose engine developed
in-house (FRoG) and the clinical treatment planning system (Syngo RT Planning). [...]
2019 - 9 p.
- Published in : Physica Medica 64 (2019) 123-131
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2.
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An overview of recent developments in FLUKA PET tools
/ Augusto, R S (CERN ; LMU Munich (main)) ; Bauer, J (Heidelberg U. Hospital) ; Bouhali, O (Texas A&M; U. Qatar, Doha) ; Cuccagna, C (CERN ; TERA, Novara ; U. Geneva (main)) ; Gianoli, C (LMU Munich (main)) ; Kozłowska, W S (CERN ; Med. U. of Vienna, Spitalgasse) ; Ortega, P G (U. Salamanca (main)) ; Tessonnier, T (Centre François Baclesse, Caen) ; Toufique, Y (Texas A&M; U. Qatar, Doha ; Hassan 1st U., Settat) ; Vlachoudis, V (CERN) et al.
The new developments of the FLUKA Positron-Emission-Tomography (PET) tools are detailed. FLUKA is a fully integrated Monte Carlo (MC) particle transport code, used for an extended range of applications, including Medical Physics. [...]
2018
- Published in : Physica Medica 54 (2018) 189-199
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3.
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Optimizing the modified microdosimetric kinetic model input parameters for proton and $^4$He ion beam therapy application
/ Mairani, A (CNAO, Milan ; Heidelberg Ion Beam Therapy Center, Heidelberg) ; Magro, G (CNAO, Milan) ; Tessonnier, T (Heidelberg U. Hospital ; LMU Munich (main)) ; Böhlen, T T (EBG MedAustron GmbH, Wiener Neustadt) ; Molinelli, S (CNAO, Milan) ; Ferrari, A (CERN) ; Parodi, K (Heidelberg Ion Beam Therapy Center, Heidelberg ; Heidelberg U. Hospital ; LMU Munich (main)) ; Debus, J (Heidelberg Ion Beam Therapy Center, Heidelberg ; Heidelberg U. Hospital) ; Haberer, T (Heidelberg Ion Beam Therapy Center, Heidelberg)
Models able to predict relative biological effectiveness (RBE) values are necessary for an accurate determination of the biological effect with proton and $^4$He ion beams. This is particularly important when including RBE calculations in treatment planning studies comparing biologically optimized proton and $^4$He ion beam plans. [...]
2017 - 13 p.
- Published in : Phys. Med. Biol. 62 (2017) N244-N256
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4.
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Dosimetric verification in water of a Monte Carlo treatment planning tool for proton, helium, carbon and oxygen ion beams at the Heidelberg Ion Beam Therapy Center
/ Tessonnier, T (Heidelberg U. Hospital ; LMU Munich (main)) ; Böhlen, TT ; Ceruti, F (CERN) ; Ferrari, A (CERN) ; Sala, P (CERN ; INFN, Milan) ; Brons, S (HITS, Heidelberg) ; Haberer, T (HITS, Heidelberg) ; Debus, J (Heidelberg U. Hospital ; HITS, Heidelberg) ; Parodi, K (Heidelberg U. Hospital ; LMU Munich (main)) ; Mairani, A (HITS, Heidelberg)
The introduction of 'new' ion species in particle therapy needs to be supported by a thorough assessment of their dosimetric properties and by treatment planning comparisons with clinically used proton and carbon ion beams. In addition to the latter two ions, helium and oxygen ion beams are foreseen at the Heidelberg Ion Beam Therapy Center (HIT) as potential assets for improving clinical outcomes in the near future. [...]
2017 - 16 p.
- Published in : Phys. Med. Biol. 62 (2017) 6579-6594
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5.
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Helium ions at the heidelberg ion beam therapy center: comparisons between FLUKA Monte Carlo code predictions and dosimetric measurements
/ Tessonnier, T (Heidelberg U. Hospital ; LMU Munich (main)) ; Mairani, A (HITS, Heidelberg) ; Brons, S (HITS, Heidelberg) ; Sala, P (CERN ; INFN, Milan) ; Cerutti, F (CERN) ; Ferrari, A (CERN) ; Haberer, T (HITS, Heidelberg) ; Debus, J (Heidelberg U. Hospital ; HITS, Heidelberg) ; Parodi, K (Heidelberg U. Hospital ; LMU Munich (main))
In the field of particle therapy helium ion beams could offer an alternative for radiotherapy treatments, owing to their interesting physical and biological properties intermediate between protons and carbon ions. We present in this work the comparisons and validations of the Monte Carlo FLUKA code against in-depth dosimetric measurements acquired at the Heidelberg Ion Beam Therapy Center (HIT). [...]
2017 - 20 p.
- Published in : Phys. Med. Biol. 62 (2017) 6784-6803
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6.
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A phenomenological relative biological effectiveness approach for proton therapy based on an improved description of the mixed radiation field
/ Mairani, A (CNAO Foundation, Pavia ; HIT, Heidelberg) ; Dokic, I (HIT, Heidelberg ; Heidelberg, Inst. Radiology) ; Magro, G (CNAO Foundation, Pavia) ; Tessonnier, T (Munich U. ; Heidelberg, Inst. Radiology) ; Bauer, J (HIT, Heidelberg ; Heidelberg, Inst. Radiology) ; Böhlen, TT (EBG GmbH MedAustron, Austria) ; Ciocca, M (CNAO Foundation, Pavia) ; Ferrari, A (CERN) ; Sala, P R (INFN, Milan) ; Jäkel, O (HIT, Heidelberg ; Heidelberg, Inst. Radiology) et al.
Proton therapy treatment planning systems (TPSs) are based on the assumption of a constant relative biological effectiveness (RBE) of 1.1 without taking into account the found in vitro experimental variations of the RBE as a function of tissue type, linear energy transfer (LET) and dose. The phenomenological RBE models available in literature are based on the dose-averaged LET (LET D ) as an indicator of the physical properties of the proton radiation field. [...]
2017 - 18 p.
- Published in : Phys. Med. Biol. 62 (2017) 1378-1395
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7.
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Biologically optimized helium ion plans: calculation approach and its in vitro validation
/ Mairani, A (CNAO, Milan ; HITS, Heidelberg) ; Dokic, I (HITS, Heidelberg ; Heidelberg, Inst. Radiology ; Heidelberg U. Hospital) ; Magro, G (CNAO, Milan) ; Tessonnier, T (Heidelberg U. Hospital ; Munich U., Neutron Group) ; Kamp, F (Munich U.) ; Carlson, D J (Yale U. (main)) ; Ciocca, M (CNAO, Milan) ; Cerutti, F (CERN) ; Sala, P R (INFN, Milan ; Yale U.) ; Ferrari, A (CERN) et al.
Treatment planning studies on the biological effect of raster-scanned helium ion beams should be performed, together with their experimental verification, before their clinical application at the Heidelberg Ion Beam Therapy Center (HIT). For this purpose, we introduce a novel calculation approach based on integrating data-driven biological models in our Monte Carlo treatment planning (MCTP) tool. [...]
2016 - 17 p.
- Published in : Phys. Med. Biol. 61 (2016) 4283-4299
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8.
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Variable RBE in proton therapy: comparison of different model predictions and their influence on clinical-like scenarios
/ Giovannini, Giulia (Munich U. ; Pavia U. ; Heidelberg, Inst. Radiology) ; Böhlen, Till (CERN ; Munich U. ; Fachhochsch., Wiener Neustadt) ; Cabal, Gonzalo (Munich U.) ; Bauer, Julia (Heidelberg Ion-Beam Therapy Center (HIT) ; Heidelberg, Inst. Radiology) ; Tessonnier, Thomas (Heidelberg, Inst. Radiology) ; Frey, Kathrin (Munich U.) ; Debus, Jürgen (Heidelberg, Inst. Radiology ; Heidelberg Ion-Beam Therapy Center (HIT)) ; Mairani, Andrea (CNAO Foundation, Pavia ; Heidelberg Ion-Beam Therapy Center (HIT)) ; Parodi, Katia (Munich U. ; Heidelberg, Inst. Radiology ; Heidelberg Ion-Beam Therapy Center (HIT))
Background: In proton radiation therapy a constant relative biological effectiveness (RBE) of 1.1 is usually assumed. However, biological experiments have evidenced RBE dependencies on dose level, proton linear energy transfer (LET) and tissue type. [...]
2016 - 16 p.
- Published in : Radiat. Oncol. 11 (2016) 68
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9.
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Next generation multi-scale biophysical characterization of high precision cancer particle radiotherapy using clinical proton, helium-, carbon- and oxygen ion beams
/ Dokic, Ivana (Heidelberg, Inst. Radiology ; HITS, Heidelberg ; Heidelberg U. Hospital) ; Mairani, Andrea (HITS, Heidelberg ; CNAO, Milan) ; Niklas, Martin (Heidelberg, Inst. Radiology ; HITS, Heidelberg ; Heidelberg U. Hospital) ; Zimmermann, Ferdinand (Heidelberg, Inst. Radiology ; HITS, Heidelberg ; Heidelberg U. Hospital) ; Chaudhri, Naved (HITS, Heidelberg) ; Krunic, Damir (Heidelberg, Inst. Radiology) ; Tessonnier, Thomas (Heidelberg U. Hospital ; Munich U.) ; Ferrari, Alfredo (CERN) ; Parodi, Katia (HITS, Heidelberg ; Munich U.) ; Jäkel, Oliver (HITS, Heidelberg ; Heidelberg, Inst. Radiology) et al.
The growing number of particle therapy facilities worldwide landmarks a novel era of precision oncology. Implementation of robust biophysical readouts is urgently needed to assess the efficacy of different radiation qualities. [...]
2016 - 14 p.
- Published in : Oncotarget 7 (2016) 56676-56689
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10.
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A model for the accurate computation of the lateral scattering of protons in water
/ Bellinzona, EV (Pavia U. ; INFN, Pavia ; Munich U.) ; Ciocca, M (CNAO, Milan) ; Embriaco, A (Pavia U. ; INFN, Pavia) ; Ferrari, A (CERN) ; Fontana, A (Munich U.) ; Mairani, A (CNAO, Milan) ; Parodi, K (Munich U. ; HITS, Heidelberg) ; Rotondi, A (Pavia U. ; INFN, Pavia) ; Sala, P (INFN, Milan) ; Tessonnier, T (Heidelberg U. Hospital)
A pencil beam model for the calculation of the lateral scattering in water of protons for any therapeutic energy and depth is presented. It is based on the full Molière theory, taking into account the energy loss and the effects of mixtures and compounds. [...]
2016 - 17 p.
- Published in : Phys. Med. Biol. 61 (2016) N102-117
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