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FLUKA particle therapy tool for Monte Carlo independent calculation of scanned proton and carbon ion beam therapy
/ Kozłowska, Wioletta Sandra (CERN ; Med. U. of Vienna, Spitalgasse) ; Böhlen, Till Tobias (PSI, Villigen) ; Cuccagna, Caterina (TERA Foundation, Geneva ; U. Geneva (main)) ; Ferrari, Alfredo (CERN) ; Fracchiolla, Francesco (Proton Therapy Center, Trento) ; Georg, Dietmar (Med. U. of Vienna, Spitalgasse ; Christian Doppler Lab., Vienna) ; Magro, Giuseppe (CNAO, Pavia) ; Mairani, Andrea (CNAO, Pavia ; Heidelberg Ion-Beam Therapy Center) ; Schwarz, Marco (Proton Therapy Center, Trento ; TIFPA-INFN, Trento) ; Vlachoudis, Vasilis (CERN)
While Monte Carlo (MC) codes are considered as the gold standard for dosimetric calculations, the availability of user friendly MC codes suited for particle therapy is limited. Based on the FLUKA MC code and its graphical user interface (GUI) Flair, we developed an easy-to-use tool which enables simple and reliable simulations for particle therapy. [...]
2019 - 12 p.
- Published in : Phys. Med. Biol. 64 (2019) 075012
Fulltext: PDF;
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Optimizing the modified microdosimetric kinetic model input parameters for proton and $^4$He ion beam therapy application
/ Mairani, A (CNAO, Milan ; Heidelberg Ion Beam Therapy Center, Heidelberg) ; Magro, G (CNAO, Milan) ; Tessonnier, T (Heidelberg U. Hospital ; LMU Munich (main)) ; Böhlen, T T (EBG MedAustron GmbH, Wiener Neustadt) ; Molinelli, S (CNAO, Milan) ; Ferrari, A (CERN) ; Parodi, K (Heidelberg Ion Beam Therapy Center, Heidelberg ; Heidelberg U. Hospital ; LMU Munich (main)) ; Debus, J (Heidelberg Ion Beam Therapy Center, Heidelberg ; Heidelberg U. Hospital) ; Haberer, T (Heidelberg Ion Beam Therapy Center, Heidelberg)
Models able to predict relative biological effectiveness (RBE) values are necessary for an accurate determination of the biological effect with proton and $^4$He ion beams. This is particularly important when including RBE calculations in treatment planning studies comparing biologically optimized proton and $^4$He ion beam plans. [...]
2017 - 13 p.
- Published in : Phys. Med. Biol. 62 (2017) N244-N256
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Biologically optimized helium ion plans: calculation approach and its in vitro validation
/ Mairani, A (CNAO, Milan ; HITS, Heidelberg) ; Dokic, I (HITS, Heidelberg ; Heidelberg, Inst. Radiology ; Heidelberg U. Hospital) ; Magro, G (CNAO, Milan) ; Tessonnier, T (Heidelberg U. Hospital ; Munich U., Neutron Group) ; Kamp, F (Munich U.) ; Carlson, D J (Yale U. (main)) ; Ciocca, M (CNAO, Milan) ; Cerutti, F (CERN) ; Sala, P R (INFN, Milan ; Yale U.) ; Ferrari, A (CERN) et al.
Treatment planning studies on the biological effect of raster-scanned helium ion beams should be performed, together with their experimental verification, before their clinical application at the Heidelberg Ion Beam Therapy Center (HIT). For this purpose, we introduce a novel calculation approach based on integrating data-driven biological models in our Monte Carlo treatment planning (MCTP) tool. [...]
2016 - 17 p.
- Published in : Phys. Med. Biol. 61 (2016) 4283-4299
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Data-driven RBE parameterization for helium ion beams
/ Mairani, A (CNAO, Milan ; HITS, Heidelberg) ; Magro, G (CNAO, Milan ; Pavia U. ; INFN, Pavia) ; Dokic, I (HITS, Heidelberg ; Heidelberg, Inst. Radiology ; Heidelberg U.) ; Valle, S M (Pavia U.) ; Tessonnier, T (Munich U., Inst. Astron. Astrophys. ; Heidelberg U.) ; Galm, R (HITS, Heidelberg ; Heidelberg, Inst. Radiology ; Heidelberg U.) ; Ciocca, M (CNAO, Milan) ; Parodi, K (HITS, Heidelberg ; Heidelberg U. ; Munich U., Inst. Astron. Astrophys.) ; Ferrari, A (CERN) ; Jäkel, O (HITS, Heidelberg ; Heidelberg, Inst. Radiology) et al.
Helium ion beams are expected to be available again in the near future for clinical use. A suitable formalism to obtain relative biological effectiveness (RBE) values for treatment planning (TP) studies is needed. [...]
2016 - 18 p.
- Published in : Phys. Med. Biol. 61 (2016) 888-905
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The FLUKA code: An accurate simulation tool for particle therapy
/ Battistoni, Giuseppe (INFN, Milan) ; Bauer, Julia (Uniklinikum, Heidelberg) ; Böhlen, Till T (Uniklinikum, Heidelberg) ; Cerutti, Francesco (CERN) ; Chin, Mary Pik Wai (CERN) ; Dos Santos Augusto, Ricardo M (LMU Munich (main) ; CERN) ; Ferrari, Alfredo (CERN) ; Garcia Ortega, Pablo (CERN) ; Kozlowska, Wioletta S (HIT, Heidelberg ; CERN) ; Magro, Giuseppe (CNAO, Milan) et al.
Monte Carlo (MC) codes are increasingly spreading in the hadrontherapy community due to their detailed description of radiation transport and interaction with matter. The suitability of a MC code for application to hadrontherapy demands accurate and reliable physical models capable of handling all components of the expected radiation field. [...]
2016
- Published in : Front. Oncol. 6 (2016) 116
Frontiers Open Access article: PDF;
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7.
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The FLUKA Code: Developments and Challenges for High Energy and Medical Applications
/ Böhlen, T T (CERN) ; Cerutti, F (CERN) ; Chin, M P W (CERN) ; Fassò, A ; Ferrari, A (CERN) ; Ortega, P G (CERN) ; Mairani, A ; Sala, P R (INFN, Milan) ; Smirnov, G (CERN) ; Vlachoudis, V (CERN)
The FLUKA Monte Carlo code is used extensively at CERN for all beam-machine interactions, radioprotection calculations and facility design of forthcoming projects. Such needs require the code to be consistently reliable over the entire energy range (from MeV to TeV) for all projectiles (full suite of elementary particles and heavy ions). [...]
2014 - 4 p.
- Published in : Nucl. Data Sheets 120 (2014) 211-214
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Performance of the reconstruction algorithms of the FIRST experiment pixel sensors vertex detector
/ Rescigno, R (Strasbourg, IPHC) ; Finck, Ch (Strasbourg, IPHC) ; Juliani, D (Strasbourg, IPHC) ; Spiriti, E (Frascati ; INFN, Rome3) ; Baudot, J (Strasbourg, IPHC) ; Abou-Haidar, Z (CNA, Seville) ; Agodi, C (INFN, LNS) ; Alvarez, M A G (CNA, Seville) ; Aumann, T (Darmstadt, GSI) ; Battistoni, G (INFN, Milan) et al.
Hadrontherapy treatments use charged particles (e.g. protons and carbon ions) to treat tumors. [...]
2014 - 7 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 767 (2014) 34-40
Elsevier Open Access article: PDF;
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A Monte Carlo-based treatment-planning tool for ion beam therapy
/ Böhlen, T T (CERN ; Stockholm U. ; Karolinska Inst., Stockholm) ; Bauer, J (Heidelberg Ion-Beam Therapy Center, Heidelberg ; Heidelberg University Clinic) ; Dosanjh, M (CERN) ; Ferrari, A (CERN) ; Haberer, T (Heidelberg Ion-Beam Therapy Center, Heidelberg) ; Parodi, K (Heidelberg Ion-Beam Therapy Center, Heidelberg ; Heidelberg University Clinic ; Munich U.) ; Patera, V (U. Rome La Sapienza) ; Mairan, A (CNAO, Pavia)
Ion beam therapy, as an emerging radiation therapy modality, requires continuous efforts to develop and improve tools for patient treatment planning (TP) and research applications. Dose and fluence computation algorithms using the Monte Carlo (MC) technique have served for decades as reference tools for accurate dose computations for radiotherapy. [...]
2013
- Published in : J. Radiat. Res. 54 (2013) i77-i81
Oxford Univ. Press Open Access article: PDF;
In : PARTNER, pp.i77-i81
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Performance of upstream interaction region detectors for the FIRST experiment at GSI
/ Abou-Haidar, Z (CNA, Seville) ; Agodi, C (INFN, LNS) ; Alvarez, M A G (CNA, Seville) ; Anelli, M (INFN, Milan) ; Aumann, T (Darmstadt, GSI) ; Battistoni, G (INFN, Milan) ; Bocci, A (CNA, Seville) ; Bohlen, T T (CERN ; Karolinska Hospital, Stockholm ; Stockholm U.) ; Boudard, A (IRFU, SPhN, Saclay) ; Brunetti, A (INFN, Cagliari ; Sassari U.) et al.
The FIRST (Fragmentation of Ions Relevant for Space and Therapy) experiment at GSI has been designed to study carbon fragmentation, measuring (12)C double differential cross sections (- (2)I /- - E) for different beam energies between 100 and 1000 MeV/u. The experimental setup integrates newly designed detectors in the, so called, Interaction Region around the graphite target. [...]
2012 - 15 p.
- Published in : JINST 7 (2012) P02006
IOP Open Access article: PDF;
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