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1.
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Dual-scattering foil installation at CLEAR
/ Robertson, Cameron (Oxford U.) ; Aksoy, Avni (Ankara U.) ; Bateman, Joseph (Oxford U.) ; Corsini, Roberto (CERN) ; Dosanjh, Manjit (CERN) ; Farabolini, Wilfrid (CERN) ; Gerbershagen, Alexander (Groningen U.) ; Korysko, Pierre (Oxford U.) ; Latina, Andrea (CERN) ; Malyzhenkov, Alexander (CERN) et al.
The CLEAR facility at CERN allows users to receive an electron beam with energy up to 200 MeV, allowing flexibility in intensity, beam size and bunch structures. Separate from the main CERN accelerator complex, it is capable of hosting numerous experiments with rapid installations at two test stands.It would be highly desirable for many applications, but particularly those of a medical nature, to be able to provide a ‘flat’ beam at CLEAR, with a uniform intensity distribution over a significant component of its transverse dimensions. [...]
2023 - 4 p.
- Published in : JACoW IPAC 2023 (2023) THPM073
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.THPM073
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2.
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The CLEAR user facility: a review of the experimental methods and future plans
/ Korysko, Pierre (Oxford U. ; CERN) ; Malyzhenkov, Alexander (CERN) ; Aksoy, Avni (CERN) ; Robertson, Cameron (Oxford U.) ; Bateman, Joseph (Oxford U.) ; Sjobak, Kyrre (Oslo U.) ; Dosanjh, Manjit (Oxford U.) ; Corsini, Roberto (CERN) ; Rieker, Vilde (CERN) ; Farabolini, Wilfrid (CERN)
The CERN Linear Accelerator for Research (CLEAR) is a test facility delivering an electron beam in the 30-220 MeV energy range to a diverse user community. In 2022, several hardware and software upgrades were done to the main installation, and procedures and methods were developed to address specific user requirements, including a further extension of the beam parameter ranges. [...]
2023 - 4 p.
- Published in : JACoW IPAC 2023 (2023) MOPL141
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.MOPL141
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3.
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Beam instrumentation for real time FLASH dosimetry: experimental studies in the CLEAR facility
/ Rieker, Vilde (CERN ; Oslo U.) ; Malyzhenkov, Alexander (CERN) ; Aksoy, Avni (Ankara U. ; CERN) ; Bateman, Joseph (Oxford U. ; CERN) ; Korysko, Pierre (Oxford U. ; CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN) ; Adli, Erik (Oslo U.) ; Sjobak, Kyrre (Oslo U.) ; Wroe, Laurence (CERN) et al.
Real-time dosimetry for ultra-high dose-rates (UHDR) and Very High Energy Electrons (VHEE) is a challenge which is currently being studied using the electron beam at CERN Linear Accelerator for Research (CLEAR). These studies are motivated by the demand for reliable dosimetry for FLASH radiotherapy. [...]
2023 - 4 p.
- Published in : JACoW IPAC 2023 (2023) THPM060
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.THPM060
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4.
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Development of reliable VHEE/FLASH passive dosimetry methods and procedures at CLEAR
/ Rieker, Vilde (CERN ; Oslo U.) ; Farabolini, Wilfrid (CERN) ; Corsini, Roberto (CERN) ; Wroe, Laurence (CERN) ; Bateman, Joseph (CERN ; Oxford U.) ; Korysko, Pierre (Oxford U. ; CERN) ; Robertson, Cameron (CERN ; Oxford U.)
The electron beam at CERN Linear Accelerator for Research (CLEAR) has been intensively used to study the potential use of Very High Energy Electrons (VHEE) for radiotherapy, including the so-called FLASH regime. An important part of these studies revolves around the development of reliable dosimetry methods, given that generally accepted standards are partly lacking for electron beams in the 100 MeV range and even more so in the ultra-high dose rates (UHDR) conditions needed for FLASH. [...]
2023
- Published in : JACoW IPAC 2023 (2023) THPM059
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.THPM059
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5.
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VHEE and ultra high dose rate radiotherapy studies in the CLEAR user facility
/ Korysko, Pierre (Oxford U. ; CERN) ; Malyzhenkov, Alexander (CERN) ; Robertson, Cameron (Oxford U.) ; Bateman, Joseph (Oxford U.) ; Dosanjh, Manjit (Oxford U.) ; Corsini, Roberto (CERN) ; Rieker, Vilde (CERN) ; Farabolini, Wilfrid (CERN)
Given the current availability of high-gradient accelerator technology for cost effective and compact electron LINACs in the 100-200 MeV energy range, using Very High Energy Electron (VHEE) radiotherapy (RT) for cancer treatment recently gained a lot of interest. The Ultra High Dose Rate (UHDR) or FLASH dose regime, in which cancerous cells are damaged while healthy tissues are largely spared is one of the main topics studied. [...]
2023 - 4 p.
- Published in : JACoW IPAC 2023 (2023) THPM078
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.THPM078
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6.
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Operational improvements and upgrades of the CLEAR user facility
/ Korysko, Pierre (Oxford U.) ; Malyzhenkov, Alexander (CERN) ; Gilardi, Antonio (CERN) ; Aksoy, Avni (CERN) ; Robertson, C (Oxford U.) ; Granados, Eduardo (CERN) ; Najmudin, I (Oxford U.) ; Wroe, Laurence (CERN) ; Martinez-Calderon, Miguel (CERN) ; Corsini, Roberto (CERN) et al.
The CERN Linear Accelerator for Research (CLEAR) at CERN is a user facility providing a 200 MeV electron beam for accelerator R&D; and irradiation studies, including medical applications. In this paper we will outline the most recent improvements in CLEAR operation and beam control and delivery, and describe the upgrades under way, giving an update of their current status. [...]
2024 - 4 p.
- Published in : JACoW LINAC 2024 (2024) THPB017
Fulltext: PDF;
In : 32nd Linear Accelerator Conference (LINAC 2024), Chicago, Illinois, United States, 25 - 30 Aug 2024, pp.THPB017
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7.
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Spatially fractionated radiotherapy with very high energy electron pencil beam scanning
/ Fischer, Jade (Victoria U.) ; Hart, Alexander (Victoria U.) ; Bedriová, Nicole (Zilina U.) ; Krim, Deae-eddine (Victoria U.) ; Clements, Nathan (Victoria U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U.) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (Oslo U.) ; Corsini, Roberto (CERN) et al.
Objective. To evaluate spatially fractionated radiation therapy (SFRT) for very-high-energy electrons (VHEEs) delivered with pencil beam scanning. [...]
2024 - 12 p.
- Published in : Phys. Med. Biol. 70 (2025) 015011
Fulltext: PDF;
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8.
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Medical activities in CLEAR: studies towards radiotherapy using Very High Energy Electrons (VHEE) in the FLASH regime
/ Corsini, Roberto (CERN) ; Malyzhenkov, Alexander (CERN) ; Gilardi, Antonio (Naples U. ; INFN, Naples) ; Aksoy, Avni (CERN) ; Robertson, Cameron (Oxford U.) ; Bateman, Joseph (Oxford U.) ; Dosanjh, Manjit (CERN) ; Korysko, Pierre (Oxford U.) ; Rieker, Vilde (CERN) ; Farabolini, Wilfrid (CERN)
Given the present availability of high-gradient accelerator technology for compact and cost-effective electron linacs in the 100-200 MeV energy range, the interest for Very High Energy Electron (VHEE) radiotherapy (RT) for cancer treatment recently reached an all-time high. Particular significance is assumed by the Ultra-High Dose Rate (UHDR) regime where the so-called FLASH biological effect takes place, in which cancer cells are damaged while healthy tissue is largely spared. [...]
2024 - 4 p.
- Published in : JACoW LINAC 2024 (2024) THPB018
Fulltext: PDF;
In : 32nd Linear Accelerator Conference (LINAC 2024), Chicago, Illinois, United States, 25 - 30 Aug 2024, pp.THPB018
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9.
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Active dosimetry for VHEE FLASH radiotherapy using beam profile monitors and charge measurements
/ Rieker, Vilde F (CERN ; Oslo U.) ; Corsini, Roberto (CERN) ; Stapnes, Steinar (CERN) ; Adli, Erik (Oslo U.) ; Farabolini, Wilfrid (CERN) ; Grilj, Veljko (SUBATECH, Nantes) ; Sjobak, Kyrre N (Oslo U.) ; Wroe, Laurence M (CERN) ; Aksoy, Avni (CERN ; Ankara U.) ; Robertson, Cameron S (Oxford U.) et al.
The discovery of the FLASH effect has revealed a high potential for treating cancer more efficiently by sparing
healthy tissue. The surge in related medical research activities over the last couple of years has triggered a
demand for technology with the capability of generating and measuring ionizing radiation at ultra-high doserates (UHDR). [...]
2024 - 12 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 1069 (2024) 169845
Fulltext: PDF;
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10.
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VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint
/ Wanstall, Hannah C (Manchester U. ; Daresbury) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfred (CERN) ; Corsini, Roberto (CERN) ; Bateman, Joseph J (Oxford U., Theor. Phys.) ; Rieker, Vilde (CERN ; Oslo U.) ; Hemming, Abigail (U. Manchester (main)) ; Henthorn, Nicholas T (U. Manchester (main) ; Manchester U.) ; Merchant, Michael J (Manchester U.) ; Santina, Elham (Manchester U.) et al.
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied across several radiation modalities, including photons, protons and clinical energy electrons, however, very little data is available for the effect of FLASH with Very High Energy Electrons (VHEE). [...]
2024 - 13 p.
- Published in : Sci. Rep. 14 (2024) 14803
Fulltext: PDF;
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