Gracheva, Nadezda - Search Results - CERN Document Server

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Alpha-PET for Prostate Cancer: Preclinical investigation using 149Tb-PSMA-617 / Umbricht, Christoph A. (PSI, Villigen) ; Gracheva, Nadezda (PSI, Villigen) ; Johnston, Karl (CERN) ; Schibli, Roger (PSI, Villigen ; Zurich, ETH) ; van der Meulen, Nicholas P. (PSI, Villigen) ; Müller, Cristina (PSI, Villigen ; ETH, Zurich) ; Bernhardt, Peter (Chalmers U. Tech.) ; Koster, Ulli (Laue-Langevin Inst.)
In this study, it was aimed to investigate$^{149}$Tb-PSMA-617 for targeted α-therapy (TAT) using a mouse model of prostate-specific membrane antigen (PSMA)-expressing prostate cancer.$^{149}$Tb-PSMA-617 was prepared with >98% radiochemical purity (6 MBq/nmol) for the treatment of mice with PSMA-positive PC-3 PIP tumors.$^{149}$Tb-PSMA-617 was applied at 1 × 6 MBq (Day 0) or 2 × 3 MBq (Day 0 & Day 1 or Day 0 & Day 3) and the mice were monitored over time until they had reached a pre-defined endpoint which required euthanasia. The tumor growth was significantly delayed in mice of the treated groups as compared to untreated controls (p < 0.05). [...]
2019 - Published in : Sci. Rep. 9 (2019) 17800 Fulltext: PDF;

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