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Dosimetric validation of Monte Carlo and analytical dose engines with raster-scanning $^1$H, $^4$He, $^{12}$C, and $^{16}$O ion-beams using an anthropomorphic phantom / Mein, Stewart (NCRO, Heidelberg ; Heidelberg U. Hospital ; DKFZ, Heidelberg) ; Kopp, Benedikt (Heidelberg U. Hospital ; Heidelberg U. ; DKFZ, Heidelberg) ; Tessonnier, Thomas (Centre Francois Baclesse, Caen) ; Ackermann, Benjamin (Heidelberg U. Hospital) ; Ecker, Swantje (Heidelberg U. Hospital) ; Bauer, Julia (Heidelberg U. Hospital) ; Choi, Kyungdon (CNAO, Pavia) ; Aricò, Giulia (CERN) ; Ferrari, Alfredo (CERN) ; Haberer, Thomas (Heidelberg U. Hospital) et al.
With high-precision radiotherapy on the rise towards mainstream healthcare, comprehensive validation procedures are essential, especially as more sophisticated technologies emerge. In preparation for the upcoming translation of novel ions, case-/disease-specific ion-beam selection and advanced multi-particle treatment modalities at the Heidelberg Ion-beam Therapy Center (HIT), we quantify the accuracy limits in particle therapy treatment planning under complex heterogeneous conditions for the four ions ($^1$H, $^4$He, $^{12}$C, $^{16}$O) using a Monte Carlo Treatment Planning platform (MCTP), an independent GPU-accelerated analytical dose engine developed in-house (FRoG) and the clinical treatment planning system (Syngo RT Planning). [...]
2019 - 9 p. - Published in : Physica Medica 64 (2019) 123-131

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Variable RBE in proton therapy: comparison of different model predictions and their influence on clinical-like scenarios / Giovannini, Giulia (Munich U. ; Pavia U. ; Heidelberg, Inst. Radiology) ; Böhlen, Till (CERN ; Munich U. ; Fachhochsch., Wiener Neustadt) ; Cabal, Gonzalo (Munich U.) ; Bauer, Julia (Heidelberg Ion-Beam Therapy Center (HIT) ; Heidelberg, Inst. Radiology) ; Tessonnier, Thomas (Heidelberg, Inst. Radiology) ; Frey, Kathrin (Munich U.) ; Debus, Jürgen (Heidelberg, Inst. Radiology ; Heidelberg Ion-Beam Therapy Center (HIT)) ; Mairani, Andrea (CNAO Foundation, Pavia ; Heidelberg Ion-Beam Therapy Center (HIT)) ; Parodi, Katia (Munich U. ; Heidelberg, Inst. Radiology ; Heidelberg Ion-Beam Therapy Center (HIT))
Background: In proton radiation therapy a constant relative biological effectiveness (RBE) of 1.1 is usually assumed. However, biological experiments have evidenced RBE dependencies on dose level, proton linear energy transfer (LET) and tissue type. [...]
2016 - 16 p. - Published in : Radiat. Oncol. 11 (2016) 68 Fulltext: PDF;

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Next generation multi-scale biophysical characterization of high precision cancer particle radiotherapy using clinical proton, helium-, carbon- and oxygen ion beams / Dokic, Ivana (Heidelberg, Inst. Radiology ; HITS, Heidelberg ; Heidelberg U. Hospital) ; Mairani, Andrea (HITS, Heidelberg ; CNAO, Milan) ; Niklas, Martin (Heidelberg, Inst. Radiology ; HITS, Heidelberg ; Heidelberg U. Hospital) ; Zimmermann, Ferdinand (Heidelberg, Inst. Radiology ; HITS, Heidelberg ; Heidelberg U. Hospital) ; Chaudhri, Naved (HITS, Heidelberg) ; Krunic, Damir (Heidelberg, Inst. Radiology) ; Tessonnier, Thomas (Heidelberg U. Hospital ; Munich U.) ; Ferrari, Alfredo (CERN) ; Parodi, Katia (HITS, Heidelberg ; Munich U.) ; Jäkel, Oliver (HITS, Heidelberg ; Heidelberg, Inst. Radiology) et al.
The growing number of particle therapy facilities worldwide landmarks a novel era of precision oncology. Implementation of robust biophysical readouts is urgently needed to assess the efficacy of different radiation qualities. [...]
2016 - 14 p. - Published in : Oncotarget 7 (2016) 56676-56689

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The FLUKA code: An accurate simulation tool for particle therapy / Battistoni, Giuseppe (INFN, Milan) ; Bauer, Julia (Uniklinikum, Heidelberg) ; Böhlen, Till T (Uniklinikum, Heidelberg) ; Cerutti, Francesco (CERN) ; Chin, Mary Pik Wai (CERN) ; Dos Santos Augusto, Ricardo M (LMU Munich (main) ; CERN) ; Ferrari, Alfredo (CERN) ; Garcia Ortega, Pablo (CERN) ; Kozlowska, Wioletta S (HIT, Heidelberg ; CERN) ; Magro, Giuseppe (CNAO, Milan) et al.
Monte Carlo (MC) codes are increasingly spreading in the hadrontherapy community due to their detailed description of radiation transport and interaction with matter. The suitability of a MC code for application to hadrontherapy demands accurate and reliable physical models capable of handling all components of the expected radiation field. [...]
2016 - Published in : Front. Oncol. 6 (2016) 116 Frontiers Open Access article: PDF;

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