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Dosimetric validation of Monte Carlo and analytical dose engines with raster-scanning $^1$H, $^4$He, $^{12}$C, and $^{16}$O ion-beams using an anthropomorphic phantom / Mein, Stewart (NCRO, Heidelberg ; Heidelberg U. Hospital ; DKFZ, Heidelberg) ; Kopp, Benedikt (Heidelberg U. Hospital ; Heidelberg U. ; DKFZ, Heidelberg) ; Tessonnier, Thomas (Centre Francois Baclesse, Caen) ; Ackermann, Benjamin (Heidelberg U. Hospital) ; Ecker, Swantje (Heidelberg U. Hospital) ; Bauer, Julia (Heidelberg U. Hospital) ; Choi, Kyungdon (CNAO, Pavia) ; Aricò, Giulia (CERN) ; Ferrari, Alfredo (CERN) ; Haberer, Thomas (Heidelberg U. Hospital) et al.
With high-precision radiotherapy on the rise towards mainstream healthcare, comprehensive validation procedures are essential, especially as more sophisticated technologies emerge. In preparation for the upcoming translation of novel ions, case-/disease-specific ion-beam selection and advanced multi-particle treatment modalities at the Heidelberg Ion-beam Therapy Center (HIT), we quantify the accuracy limits in particle therapy treatment planning under complex heterogeneous conditions for the four ions ($^1$H, $^4$He, $^{12}$C, $^{16}$O) using a Monte Carlo Treatment Planning platform (MCTP), an independent GPU-accelerated analytical dose engine developed in-house (FRoG) and the clinical treatment planning system (Syngo RT Planning). [...]
2019 - 9 p. - Published in : Physica Medica 64 (2019) 123-131

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In Vivo Validation of the BIANCA Biophysical Model: Benchmarking against Rat Spinal Cord RBE Data / Carante, Mario P (INFN, Pavia) ; Aricò, Giulia (CERN) ; Ferrari, Alfredo (CERN) ; Karger, Christian P (Heidelberg, Inst. Radiology) ; Kozlowska, Wioletta (CERN ; Med. U. of Vienna, Spitalgasse) ; Mairani, Andrea (HITS, Heidelberg) ; Sala, Paola (INFN, Milan) ; Ballarini, Francesca (INFN, Pavia ; Pavia U.)
(1) Background: Cancer ion therapy is constantly growing thanks to its increased precision and, for heavy ions, its increased biological effectiveness (RBE) with respect to conventional photon therapy. The complex dependence of RBE on many factors demands biophysical modeling. [...]
2020 - 11 p. - Published in : International Journal of Molecular Sciences 21 (2020) 3973 Fulltext from publisher: PDF;

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Benchmarking of FLUKA production cross sections of positron emission tomography isotopes for in-vivo range verification in hadron therapy / Aricò, Giulia (CERN) ; Battistoni, Giuseppe (INFN, Milan ; TIFPA-INFN, Trento) ; Cerutti, Francesco (CERN) ; Horst, Felix (Darmstadt, GSI ; Mittelhessen U., Giessen) ; Mairani, Andrea (HITS, Heidelberg ; pavia cnao) ; Schuy, Christoph (Darmstadt, GSI) ; Weber, Uli (Darmstadt, GSI) ; Ferrari, Alfredo (CERN)
Protons and carbon ions have been extensively used for radiotherapy treatments, and in comparison to conventional radiotherapy, they allow a more conformal dose to the target tumor, especially in case of deep-seated tumors. However, the accuracy of hadron therapy treatments is affected by uncertainties in the particle range calculations. [...]
2020 - 4 p. - Published in : EPJ Web Conf. 239 (2020) 24001
In : International Conference on Nuclear Data for Science and Technology (ND 2019), Beijing, China, 19 - 24 May 2019, pp.24001

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Measurement of PET isotope production cross sections for protons and carbon ions on carbon and oxygen targets for applications in particle therapy range verification / Horst, Felix (Darmstadt, GSI ; Mittelhessen U., Giessen) ; Adi, Wihan (Mittelhessen U., Giessen ; Giessen U.) ; Aricò, Giulia (CERN) ; Brinkmann, Kai-Thomas (Giessen U.) ; Durante, Marco (Darmstadt, GSI ; Darmstadt, Tech. U.) ; Reidel, Claire-Anne (Darmstadt, GSI ; Strasbourg, IPHC) ; Rovituso, Marta (TIFPA-INFN, Trento ; Unlisted, NL) ; Weber, Uli (Darmstadt, GSI) ; Zaunick, Hans-Georg (Giessen U.) ; Zink, Klemens (Frankfurt U., FIAS ; Mittelhessen U., Giessen ; U. Hospital, Giessen-Marburg) et al.
Measured cross sections for the production of the PET isotopes , and from carbon and oxygen targets induced by protons (40–220 ) and carbon ions (65–430 ) are presented. These data were obtained via activation measurements of irradiated graphite and beryllium oxide targets using a set of three scintillators coupled by a coincidence logic. [...]
2019 - 16 p. - Published in : Phys. Med. Biol. 64 (2019) 205012 Fulltext: PDF;

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Measurement of $^4$He charge- and mass-changing cross sections on H, C, O, and Si targets in the energy range 70–220 MeV/u for radiation transport calculations in ion-beam therapy / Horst, Felix (Giessen U. ; Darmstadt, GSI) ; Aricò, Giulia (CERN) ; Brinkmann, Kai-Thomas (U. Giessen, II. Phys. Inst.) ; Brons, Stephan (Heidelberg U.) ; Ferrari, Alfredo (CERN) ; Haberer, Thomas (Heidelberg U.) ; Mairani, Andrea (Heidelberg U. ; CNAO, Pavia) ; Parodi, Katia (Munich U.) ; Reidel, Claire-Anne (Darmstadt, GSI ; Strasbourg, IPHC) ; Weber, Uli (Darmstadt, GSI) et al.
Measured charge- and mass-changing cross sections for the systems He4+C12, He4+O16, He4+Si28, and He4+H1 in the energy range 70–220MeV/u are presented. The cross sections were obtained via the attenuation method where a ΔE-E scintillator telescope was used for particle identification. [...]
2019 - 11 p. - Published in : Phys. Rev. C 99 (2019) 014603 Fulltext from publisher: PDF;

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