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A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma / Ruffieux, Hélène (Ecole Polytechnique, Lausanne) ; Carayol, Jérôme (Ecole Polytechnique, Lausanne) ; Popescu, Radu (CERN) ; Harper, Mary-Ellen (Ottawa U.) ; Dent, Robert (Ottawa Hospital) ; Saris, Wim H M (Maastricht U.) ; Astrup, Arne (Copenhagen U.) ; Hager, Jörg (Ecole Polytechnique, Lausanne) ; Davison, Anthony C (Ecole Polytechnique, Lausanne) ; Valsesia, Armand (Ecole Polytechnique, Lausanne)
Molecular quantitative trait locus (QTL) analyses are increasingly popular to explore the genetic architecture of complex traits, but existing studies do not leverage shared regulatory patterns and suffer from a large multiplicity burden, which hampers the detection of weak signals such as trans associations. Here, we present a fully multivariate proteomic QTL (pQTL) analysis performed with our recently proposed Bayesian method LOCUS on data from two clinical cohorts, with plasma protein levels quantified by mass-spectrometry and aptamer-based assays. [...]
2020 - 24 p. - Published in : PLoS Comp. Bio. 16 (2020) e1007882 Fulltext from publisher: PDF;

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