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{{Main|游离药物}}
[[File:Salviadivinorum.jpg|thumb|175px|right|墨西哥鼠尾草 Salvia divinorum]]
游離藥物在麻醉劑量時能產生止痛、失憶、強直性暈厥的效果<ref>{{cite journal |first1=John W. |last1=Pender |month=November |year=1970 |title=Dissociative Anesthesia |journal=California Medicine |pmid=18730444 |volume=113 |issue=5 |page=73 |pmc=1501800|date=November 1970}}</ref>,同時也會引發與周遭環境的脫離感,因而達到「游離麻醉」。<ref>{{cite journal |first1=John W. |last1=Pender |month=October |year=1972 |title=Dissociative Anesthesia |journal=California Medicine |pmid=18730832 |volume=117 |issue=4 |pages=46–47 |pmc=1518731|date=October 1972}}</ref>游離的症狀包括「意識、記憶、身分識別、思緒的整合功能」崩潰或區隔化。<ref>American Psychiatric Association. Diagnostic and statistical manual of mental disorders (4th ed., text revision). Washington, DC: American Psychiatric Association, 2000.</ref><sup>p.&nbsp;523</sup>輸入感覺的游離會造成[[失實症|失實]],對於外界產生如夢或不實際的感受。其他游離體驗包括[[人格解體]]:感覺從自身肉體脫離;感覺到超現實;像是從外界觀看而無法控制;即使知道鏡子裡的影像是自己卻還是無法辨識。<ref>{{cite journal |first1=Daphne |last1=Simeon |first2=Shira |last2=Gross |first3=Orna |last3=Guralnik |first4=Dan J. |last4=Stein |first5=James |last5=Schmeidler |first6=Eric |last6=Hollander |title=Feeling unreal: 30 cases of DSM-III-R depersonalization disorder |pmid=9247397 |date=08/01/1997 |pages=1107–13 |issue=8 |volume=154 |journal=American Journal of Psychiatry |url=http://ajp.psychiatryonline.org/cgi/pmidlookup?view=long&pmid=9247397}}</ref><ref>Nathan. [http://www.erowid.org/experiences/exp.php?ID=10860 Mostly not regretful]. Erowid Experience Valuts. 29 October 2006.</ref><ref>Keil. [http://www.erowid.org/experiences/exp.php?ID=7799 Like nothing else in the world]. Erowid Experience Vaults. 11 August 2003.</ref>希蒙(2004)寫到:「……對於游離經驗的常見描述:從外界觀看自身(像是在看電影);[[靈魂出竅]];越過動作的感受;以整體視角觀測部分行動……」<ref>{{cite journal |first1=Daphne |last1=Simeon |title=Depersonalisation disorder: a contemporary overview. |pmid=15089102 |year=2004 |pages=343–54 |issue=6 |volume=18 |journal=CNS Drugs |url=http://content.wkhealth.com/linkback/openurl?issn=1172-7047&volume=18&issue=6&spage=343 |doi=10.2165/00023210-200418060-00002}}</ref>
 
== 譫妄药物 ==