When programming in python, using Idiomatic python is normally the way to go. One of python idioms is EAFP: Easier to ask for forgiveness than permission. So try creating a directory, if it exists you'll get an error you can catch.
example
import os, errno
try:
os.makedirs('my_folder')
except OSError as e:
# If error is not already exists, then raise the error else continue
if e.errno != errno.EEXIST:
raise
# Now do what you want with my_folder