Pages that link to "Q40164619"
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The following pages link to Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma (Q40164619):
Displayed 50 items.
- Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy (Q24635408) (← links)
- Small-molecule Bcl-2 antagonists as targeted therapy in oncology (Q24646161) (← links)
- BH3 mimetics to improve cancer therapy; mechanisms and examples (Q24655483) (← links)
- Regulation of Bim in Health and Disease (Q26781203) (← links)
- Bcl-2 antagonists: a proof of concept for CLL therapy (Q26823996) (← links)
- Targeting the apoptosis pathway in hematologic malignancies (Q27024422) (← links)
- Structure and Function of the RedJ Protein, a Thioesterase from the Prodiginine Biosynthetic Pathway in Streptomyces coelicolor (Q27667690) (← links)
- In vitro models of cancer stem cells and clinical applications (Q28076101) (← links)
- Anticancer and immunosuppressive properties of bacterial prodiginines (Q28258853) (← links)
- MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents (Q30502341) (← links)
- Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia (Q33381678) (← links)
- Effect of noncompetitive proteasome inhibition on bortezomib resistance (Q33588424) (← links)
- Emerging Bcl-2 inhibitors for the treatment of cancer (Q33682689) (← links)
- BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention. (Q33727248) (← links)
- Why anti-Bcl-2 clinical trials fail: a solution (Q33758493) (← links)
- Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo (Q33930057) (← links)
- Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress (Q33989217) (← links)
- Pan-Bcl-2 inhibitor, GX15-070 (obatoclax), decreases human T regulatory lymphocytes while preserving effector T lymphocytes: a rationale for its use in combination immunotherapy (Q34004454) (← links)
- Effect of a small molecule BCL-2 inhibitor on immune function and use with a recombinant vaccine (Q34074715) (← links)
- RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells (Q34104089) (← links)
- Targeting mitochondria for cancer therapy (Q34115304) (← links)
- Prognostic impact of bim, puma, and noxa expression in human colon carcinomas. (Q34167987) (← links)
- BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells (Q34168014) (← links)
- Proapoptotic Bad and Bid protein expression predict survival in stages II and III colon cancers (Q34168039) (← links)
- Jacarelhyperol A induced apoptosis in leukaemia cancer cell through inhibition the activity of Bcl-2 proteins (Q34256092) (← links)
- VSV Oncolysis in Combination With the BCL-2 Inhibitor Obatoclax Overcomes Apoptosis Resistance in Chronic Lymphocytic Leukemia (Q34382986) (← links)
- Molecular interactions of prodiginines with the BH3 domain of anti-apoptotic Bcl-2 family members (Q34608671) (← links)
- Optimization of circulating biomarkers of obatoclax-induced cell death in patients with small cell lung cancer (Q34763661) (← links)
- OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis (Q35075657) (← links)
- Small molecule inhibitors of bcl-2 family proteins for pancreatic cancer therapy (Q35099238) (← links)
- Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation (Q35125652) (← links)
- Obatoclax regulates the proliferation and fusion of osteoclast precursors through the inhibition of ERK activation by RANKL (Q35188522) (← links)
- Violacein induces p44/42 mitogen-activated protein kinase-mediated solid tumor cell death and inhibits tumor cell migration (Q35628391) (← links)
- Optical properties of prodigiosin and obatoclax: action spectroscopy and theoretical calculations (Q35676827) (← links)
- Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy (Q35742477) (← links)
- Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process (Q36057887) (← links)
- CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies (Q36170136) (← links)
- Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis (Q36288687) (← links)
- Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates (Q36372894) (← links)
- Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review (Q36541458) (← links)
- Glucocorticoid-induced apoptosis of healthy and malignant lymphocytes (Q36628641) (← links)
- An evidence-based review of obatoclax mesylate in the treatment of hematological malignancies (Q36696524) (← links)
- Obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC-DLBCL cells in vitro and in vivo (Q36697045) (← links)
- GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells (Q36759341) (← links)
- Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis (Q36845783) (← links)
- Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation (Q36952270) (← links)
- Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy. (Q36960751) (← links)
- Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma (Q36988067) (← links)
- Novel therapies targeting the apoptosis pathway for the treatment of acute myeloid leukemia (Q37001406) (← links)
- Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy? (Q37120213) (← links)