HTLV Deregulation of the NF-κB Pathway: An Update on Tax and Antisense Proteins Role. (Q52728051)

http://europepmc.org/abstract/PMC/5826390

6 May 2018

title

HTLV Deregulation of the NF-κB Pathway: An Update on Tax and Antisense Proteins Role. (English)

1 reference

http://europepmc.org/abstract/PMC/5826390

6 May 2018

0 references

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29515558%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Stefania Fochi

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29515558%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Simona Mutascio

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29515558%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Umberto Bertazzoni

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29515558%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Maria G Romanelli

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29515558%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

publication date

21 February 2018

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http://europepmc.org/abstract/PMC/5826390

6 May 2018

published in

Frontiers in Microbiology

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29515558%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

volume

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29515558%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

page(s)

285

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29515558%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

6 June 2020

copyright license

start time

21 February 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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HTLV-1 basic leucine zipper factor downregulates cyclin D1 expression via interactions with NF-κB.

22 May 2018

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Adult T-cell leukemia: molecular basis for clonal expansion and transformation of HTLV-1-infected T cells.

22 May 2018

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HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains

22 May 2018

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Role of the HTLV-1 viral factors in the induction of apoptosis.

22 May 2018

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Reducing the global burden of HTLV-1 infection: An agenda for research and action

22 May 2018

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HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZ

22 May 2018

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Identification of TBK1 and IKKε, the non-canonical IκB kinases, as crucial pro-survival factors in HTLV-1-transformed T lymphocytes

22 May 2018

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HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin Chains

22 May 2018

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Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis

22 May 2018

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The Role of HBZ in HTLV-1-Induced Oncogenesis

22 May 2018

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Functional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis

22 May 2018

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The Major Histocompatibility Complex Class II Transactivator CIITA Inhibits the Persistent Activation of NF-κB by the Human T Cell Lymphotropic Virus Type 1 Tax-1 Oncoprotein

22 May 2018

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Polycomb-dependent epigenetic landscape in adult T-cell leukemia

22 May 2018

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Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB.

22 May 2018

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HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT).

22 May 2018

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Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1.

22 May 2018

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I-mfa domain proteins specifically interact with HTLV-1 Tax and repress its transactivating functions.

22 May 2018

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The autophagy molecule Beclin 1 maintains persistent activity of NF-κB and Stat3 in HTLV-1-transformed T lymphocytes

22 May 2018

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HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation.

22 May 2018

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Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling

22 May 2018

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HTLV-1 Tax protein recruitment into IKKε and TBK1 kinase complexes enhances IFN-I expression.

22 May 2018

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Regulation of HTLV-1 tax stability, cellular trafficking and NF-κB activation by the ubiquitin-proteasome pathway

22 May 2018

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A critical role for IL-17RB signaling in HTLV-1 tax-induced NF-κB activation and T-cell transformation

22 May 2018

1 reference

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A non-SUMOylated tax protein is still functional for NF-κB pathway activation

22 May 2018

1 reference

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HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

HTLV-1 bZIP factor supports proliferation of adult T cell leukemia cells through suppression of C/EBPα signaling

22 May 2018

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Human T-cell leukemia virus type 1 Tax-deregulated autophagy pathway and c-FLIP expression contribute to resistance against death receptor-mediated apoptosis

22 May 2018

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HSP90 protects the human T-cell leukemia virus type 1 (HTLV-1) tax oncoprotein from proteasomal degradation to support NF-κB activation and HTLV-1 replication

22 May 2018

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Highlights on distinctive structural and functional properties of HTLV Tax proteins

22 May 2018

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The MHC-II transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators

22 May 2018

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Functional comparison of antisense proteins of HTLV-1 and HTLV-2 in viral pathogenesis

22 May 2018

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Ubiquitination and sumoylation of the HTLV-2 Tax-2B protein regulate its NF-κB activity: a comparative study with the HTLV-1 Tax-1 protein

22 May 2018

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Interplay between the HTLV-2 Tax and APH-2 proteins in the regulation of the AP-1 pathway

22 May 2018

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Epidemiological Aspects and World Distribution of HTLV-1 Infection

22 May 2018

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Human T cell leukemia virus type 2 tax-mediated NF-κB activation involves a mechanism independent of Tax conjugation to ubiquitin and SUMO.

22 May 2018

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Molecular hallmarks of adult T cell leukemia

22 May 2018

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Low nuclear body formation and tax SUMOylation do not prevent NF-kappaB promoter activation

22 May 2018

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HTLV-2 Tax immortalizes human CD4+ memory T lymphocytes by oncogenic activation and dysregulation of autophagy

22 May 2018

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HBZ and its roles in HTLV-1 oncogenesis

22 May 2018

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Human T-cell leukemia virus type 2 antisense viral protein 2 is dispensable for in vitro immortalization but functions to repress early virus replication in vivo

22 May 2018

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Dynamic roles for NF-κB in HTLV-I and HIV-1 retroviral pathogenesis

22 May 2018

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The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP.

22 May 2018

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HTLV-2 APH-2 expression is correlated with proviral load but APH-2 does not promote lymphocytosis

22 May 2018

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Intracellular localization and cellular factors interaction of HTLV-1 and HTLV-2 Tax proteins: similarities and functional differences.

22 May 2018

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Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesis

22 May 2018

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NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ.

22 May 2018

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ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells

22 May 2018

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Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy

22 May 2018

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Emerging roles for the non-canonical IKKs in cancer

22 May 2018

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Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures participates in Tax-mediated NF-κB activation

22 May 2018

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Molecular determinants of PDLIM2 in suppressing HTLV-I Tax-mediated tumorigenesis

22 May 2018

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Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis

22 May 2018

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Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2.

22 May 2018

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Induction of p21(CIP1/WAF1) expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization

22 May 2018

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Deregulation of microRNA involved in hematopoiesis and the immune response in HTLV-I adult T-cell leukemia

22 May 2018

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In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

22 May 2018

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PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation

22 May 2018

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Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-kappaB.

22 May 2018

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Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1

22 May 2018

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An interaction between the human T cell leukemia virus type 1 basic leucine zipper factor (HBZ) and the KIX domain of p300/CBP contributes to the down-regulation of tax-dependent viral transcription by HBZ

22 May 2018

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HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein

22 May 2018

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The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation

22 May 2018

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Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line

22 May 2018

1 reference

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Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Preferential selection of human T-cell leukemia virus type 1 provirus lacking the 5' long terminal repeat during oncogenesis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Modulation of nuclear factor-kappaB by human T cell leukemia virus type 1 Tax protein: implications for oncogenesis and inflammation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-kappaB activation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Localization of human T-cell lymphotropic virus type II Tax protein is dependent upon a nuclear localization determinant in the N-terminal region.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

5'-long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Phosphorylation of the human T-cell leukemia virus type 1 transactivator tax on adjacent serine residues is critical for tax activation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Bcl-3 suppresses Tax-induced NF-κB activation through p65 nuclear translocation blockage in HTLV-1-infected cells

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Polycomb-mediated loss of miR-31 activates NIK-dependent NF-κB pathway in adult T cell leukemia and other cancers.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5826390

13 August 2018

Identifiers

DOI

10.3389/FMICB.2018.00285

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29515558%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29515558%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

PubMed publication ID

29515558

1 reference