Interleukin-21 receptor blockade inhibits secondary humoral responses and halts the progression of preestablished disease in the (NZB × NZW)F1 systemic lupus erythematosus model (Q46273645)

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scientific article published on 19 June 2015

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English	Interleukin-21 receptor blockade inhibits secondary humoral responses and halts the progression of preestablished disease in the (NZB × NZW)F1 systemic lupus erythematosus model	scientific article published on 19 June 2015

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

Interleukin-21 receptor blockade inhibits secondary humoral responses and halts the progression of preestablished disease in the (NZB × NZW)F1 systemic lupus erythematosus model (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

author name string

Ming Zhang

1

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

Gang Yu

2

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

Brian Chan

3

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

Joshua T Pearson

4

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

Palaniswami Rathanaswami

5

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

John Delaney

6

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

Ai Ching Lim

7

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

John Babcook

8

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

Hailing Hsu

9

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

Marc A Gavin

10

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

publication date

19 June 2015

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

Arthritis & Rheumatology

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

67

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

10

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

2723-2731

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

Interleukin-21: a double-edged sword with therapeutic potential

1 reference

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21 January 2018

Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage.

1 reference

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21 January 2018

Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration

1 reference

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21 January 2018

IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice

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21 January 2018

IL-21 is required to control chronic viral infection

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21 January 2018

Human IL-21 and IL-21R deficiencies: two novel entities of primary immunodeficiency.

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21 January 2018

Targeting interleukin-21 in immune-mediated pathologies

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21 January 2018

Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus.

1 reference

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21 January 2018

A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice

1 reference

https://api.crossref.org/works/10.1002%2FART.39233

21 January 2018

IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.

1 reference

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21 January 2018

A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice.

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21 January 2018

Limiting dilution assay for human B cells based on their activation by mutant EL4 thymoma cells: total and antimalaria responder B cell frequencies

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21 January 2018

A novel strategy for generating monoclonal antibodies from single, isolated lymphocytes producing antibodies of defined specificities

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21 January 2018

A critical role for IL-21 in regulating immunoglobulin production

1 reference

https://api.crossref.org/works/10.1002%2FART.39233

21 January 2018

Treatment of murine lupus with monoclonal antibody to L3T4. I. Effects on the distribution and function of lymphocyte subsets and on the histopathology of autoimmune disease

1 reference

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21 January 2018

Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus

1 reference

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21 January 2018

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

1 reference

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21 January 2018

IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells.

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21 January 2018

Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells

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21 January 2018

Sialylation determines the nephritogenicity of IgG3 cryoglobulins

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21 January 2018

Therapeutic Effect of Early Thymic Irradiation in (NZB × NZW)F1 Mice, Associated with a Selective Decrease in the Levels of IgG3 and gp70-Anti-gp70 Immune Complexes

1 reference

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21 January 2018

Beneficial effects of the anti-oestrogen tamoxifen on systemic lupus erythematosus of (NZBxNZW)F1 female mice are associated with specific reduction of IgG3 autoantibodies

1 reference

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21 January 2018

In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon

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21 January 2018

Cutting edge: reversal of murine lupus nephritis with CTLA4Ig and cyclophosphamide

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21 January 2018

Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies

1 reference

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21 January 2018

IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells

1 reference

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21 January 2018

IL-21 promotes skin recruitment of CD4(+) cells and drives IFN-γ-dependent epidermal hyperplasia

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21 January 2018

ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus

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21 January 2018

Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis.

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21 January 2018

Interferon-inducible Ifi200-family genes as modifiers of lupus susceptibility

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21 January 2018

Genetic variation at a Yin-Yang 1 response site regulates the transcription of cyclin-dependent kinase inhibitor p18INK4C transcript in lupus-prone mice

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21 January 2018

Murine lupus susceptibility locus Sle1c2 mediates CD4+ T cell activation and maps to estrogen-related receptor γ.

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Polymorphism of the mouse gene for the interleukin 10 receptor alpha chain (Il10ra) and its association with the autoimmune phenotype

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Identification of a lupus-susceptibility locus leading to impaired clearance of apoptotic debris on New Zealand Black chromosome 13.

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Murine lupus susceptibility locus Sle2 activates DNA-reactive B cells through two sub-loci with distinct phenotypes

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Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells

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Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells

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Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2

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Inflammation and lymphopenia trigger autoimmunity by suppression of IL-2-controlled regulatory T cell and increase of IL-21-mediated effector T cell expansion.

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21 January 2018

Identifiers

10.1002/ART.39233

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26097207

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