Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2 (Q34803113)

4 August 2017

title

Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2 (English)

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4 August 2017

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B F McAdam

1

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4 August 2017

F Catella-Lawson

2

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4 August 2017

I A Mardini

3

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4 August 2017

S Kapoor

4

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4 August 2017

J A Lawson

5

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4 August 2017

G A FitzGerald

6

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4 August 2017

language of work or name

English

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publication date

1 January 1999

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4 August 2017

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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4 August 2017

volume

96

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4 August 2017

issue

1

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4 August 2017

page(s)

272-277

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Aspirin-like molecules that covalently inactivate cyclooxygenase-2.

4 August 2017

cites work

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Altered pain perception and inflammatory response in mice lacking prostacyclin receptor

8 July 2018

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Cyclooxygenase-2 inhibitors: a new class of anti-inflammatory agents that spare the gastrointestinal tract

8 July 2018

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Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.

8 July 2018

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Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor

8 July 2018

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Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

8 July 2018

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Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils

8 July 2018

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Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

8 July 2018

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Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear str

8 July 2018

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Prostaglandin endoperoxide H synthases-1 and -2.

8 July 2018

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Effects of the novel anti-inflammatory compounds, N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulphonamide (NS-398) and 5-methanesulphonamido-6-(2,4-difluorothio-phenyl)-1-inda none (L-745,337), on the cyclo-oxygenase activity of human blood prostagl

8 July 2018

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Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.

8 July 2018

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Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines

8 July 2018

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Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells

8 July 2018

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Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Prostaglandin G/H synthase isoenzyme 2 expression in fibroblasts: regulation by dexamethasone, mitogens, and oncogenes

8 July 2018

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Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

8 July 2018

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Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Interactions of PGH synthase isozymes-1 and -2 with NSAIDs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs

8 July 2018

1 reference

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A better understanding of anti-inflammatory drugs based on isoforms of cyclooxygenase (COX-1 and COX-2).

8 July 2018

1 reference

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Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

The biochemical pharmacology of thromboxane synthase inhibition in man.

8 July 2018

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Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Paired analysis of urinary thromboxane B2 metabolites in humans.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Inflammation and the mechanism of action of anti-inflammatory drugs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

The eicosanoids and their biochemical mechanisms of action

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Mechanisms of NSAID-induced gastroenteropathy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Suppression of thromboxane A2 but not of systemic prostacyclin by controlled-release aspirin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Human cyclooxygenase-2 cDNA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Prostanoid biosynthesis and mechanisms of action

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Simultaneous mass spectrometric measurement of prostaglandins E1 (PGE1) and PGE2 with a deuterated internal standard

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Interleukin 10 suppression of monocyte prostaglandin H synthase-2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15129

Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects

26 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Metabolic disposition of prostacyclin in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Platelet activation in unstable coronary disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Effects of low-dose aspirin on endogenous eicosanoid formation in normal and atherosclerotic men

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Measurement of thromboxane metabolites by gas chromatography-mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Suppression of eicosanoid biosynthesis during coronary angioplasty by fish oil and aspirin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Presystemic acetylation of platelets by aspirin: reduction in rate of drug delivery to improve biochemical selectivity for thromboxane A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Regulation of cyclooxygenase-2 expression in aortic smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Differential sensitivities of human blood monocytes and alveolar macrophages to the inhibition of prostaglandin endoperoxide synthase-2 by interleukin-4

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Changes in peripheral hemodynamics and vasodilating prostaglandins after high-dose short-term ibuprofen in chronically treated hypertensive patients

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https://pubmed.ncbi.nlm.nih.gov/9874808

12 December 2020

Identifiers

DOI

10.1073/PNAS.96.1.272

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4 August 2017

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4 August 2017

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