The role of PI3K in immune cells (Q28186713)

Signal transduction by the TCR for antigen

Europe PubMed Central

title

The role of PI3K in immune cells (English)

0 references

author name string

Shigeo Koyasu

series ordinal

1

0 references

language of work or name

English

0 references

publication date

April 2003

0 references

published in

Nature Immunology

0 references

volume

4

0 references

issue

4

0 references

page(s)

313-9

0 references

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Regulation of B-cell signal transduction by adaptor proteins

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Structure and function of phosphoinositide 3-kinases.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Synthesis and function of 3-phosphorylated inositol lipids

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Structural insights into phosphoinositide 3-kinase catalysis and signalling

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Phosphoinositide 3-kinases in T lymphocyte activation

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Regulation of B-cell activation and differentiation by the phosphatidylinositol 3-kinase and phospholipase Cgamma pathway

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Regulation of phospholipase C-gamma2 and phosphoinositide 3-kinase pathways by adaptor proteins in B lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Signalling through the high-affinity IgE receptor Fc epsilonRI.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

A point mutation in CD28 distinguishes proliferative signals from survival signals

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

The physiologic role of CD19 cytoplasmic tyrosines

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

The p85 Subunit of Phosphatidylinositol 3-Kinase Associates with the Fc Receptor γ-Chain and Linker for Activitor of T Cells (LAT) in Platelets Stimulated by Collagen and Convulxin

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

https://api.crossref.org/works/10.1038%2FNI0403-313

1 reference

7 January 2021

Antigen-receptor cross-linking and lipopolysaccharide trigger distinct phosphoinositide 3-kinase-dependent pathways to NF-kappa B activation in primary B cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Phosphatidylinositol 3-kinase and NF-kappa B/Rel are at the divergence of CD40-mediated proliferation and survival pathways

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

The PI3 kinase, p38 SAP kinase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

PI3K-mediated negative feedback regulation of IL-12 production in DCs

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Btk function in B cell development and response.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Pten is essential for embryonic development and tumour suppression

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Distinct roles for the p110alpha and hVPS34 phosphatidylinositol 3'-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Toll-like receptors: critical proteins linking innate and acquired immunity

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

IFN-gamma production by antigen-presenting cells: mechanisms emerge.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Nitric oxide and macrophage function

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Essential role for Gab2 in the allergic response

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Requirement for B cell linker protein (BLNK) in B cell development

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Immunodeficiency in protein kinase cbeta-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Imaging antigen-induced PI3K activation in T cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

The Listeria monocytogenes protein InlB is an agonist of mammalian phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt.

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

Enteropathogenic Escherichia coli mediates antiphagocytosis through the inhibition of PI 3-kinase-dependent pathways

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021

SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase

1 reference

https://api.crossref.org/works/10.1038%2FNI0403-313

7 January 2021