Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes (Q24551045)

1

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S M Medghalchi

2

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R G Lake

3

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E N Noensie

4

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H C Dietz

Molecular and Cellular Biology

5

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language of work or name

English

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publication date

December 2000

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published in

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volume

20

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issue

23

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page(s)

8944-57

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cites work

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SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast

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Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein

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A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation

24 March 2017

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The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

24 March 2017

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Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation

24 March 2017

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Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A

24 March 2017

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Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein

24 March 2017

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A new translational regulator with homology to eukaryotic translation initiation factor 4G

24 March 2017

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DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death

24 March 2017

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Mammalian orthologues of a yeast regulator of nonsense transcript stability

24 March 2017

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Murine mucopolysaccharidosis type VII. Characterization of a mouse with beta-glucuronidase deficiency

24 March 2017

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An analysis of vertebrate mRNA sequences: intimations of translational control

24 March 2017

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Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p

24 March 2017

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A factor required for nonsense-mediated mRNA decay in yeast is exported from the nucleus to the cytoplasm by a nuclear export signal sequence.

24 March 2017

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Relationship between yeast polyribosomes and Upf proteins required for nonsense mRNA decay

24 March 2017

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Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover

24 March 2017

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Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen

24 March 2017

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The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm

24 March 2017

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Epitope tagging of yeast genes using a PCR-based strategy: more tags and improved practical routines

24 March 2017

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High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

24 March 2017

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A tale of two termini: a functional interaction between the termini of an mRNA is a prerequisite for efficient translation initiation

24 March 2017

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Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1

24 March 2017

1 reference

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A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme

24 March 2017

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Molecular genetic analysis of fission yeast Schizosaccharomyces pombe

24 March 2017

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Nonsense-mediated mRNA decay in health and disease

7 April 2017

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Starting at the beginning, middle, and end: translation initiation in eukaryotes

7 April 2017

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Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G

7 April 2017

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Premature translational termination triggers mRNA decapping

7 April 2017

1 reference

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The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon

7 April 2017

1 reference

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Degradation of mRNA in eukaryotes

7 April 2017

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Recognition of yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping

7 April 2017

1 reference

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Yeast Upf proteins required for RNA surveillance affect global expression of the yeast transcriptome

27 September 2017

1 reference

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Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover

27 September 2017

1 reference

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Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae

27 September 2017

1 reference

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Mutations in the MOF2/SUI1 gene affect both translation and nonsense-mediated mRNA decay.

27 September 2017

1 reference

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RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer

27 September 2017

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smg-7 is required for mRNA surveillance in Caenorhabditis elegans.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86549

mRNA stabilization by poly(A) binding protein is independent of poly(A) and requires translation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86549

A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86549

Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86549

Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86549

Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86549

A single-base-pair deletion in the beta-glucuronidase gene accounts for the phenotype of murine mucopolysaccharidosis type VII

27 September 2017

1 reference

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Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86549

Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay

27 September 2017

1 reference

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Nuclear degradation of nonsense mutated beta-globin mRNA: a post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of beta-thalassemia?

27 September 2017

1 reference

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When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86549

Identification of an additional gene required for eukaryotic nonsense mRNA turnover

27 September 2017

1 reference

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Nonsense mutations in the dihydrofolate reductase gene affect RNA processing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86549

A new kind of informational suppression in the nematode Caenorhabditis elegans

27 September 2017

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High-frequency transformation method and library transducing vectors for cloning mammalian cDNAs by trans-complementation of Schizosaccharomyces pombe

27 September 2017

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Gene products that promote mRNA turnover in Saccharomyces cerevisiae

27 September 2017

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The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein

27 September 2017

1 reference

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Interference of nonsense mutations with eukaryotic messenger RNA stability

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86549

Cytoplasmic mRNA for human triosephosphate isomerase is immune to nonsense-mediated decay despite forming polysomes

27 September 2017

1 reference

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A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro

27 September 2017

1 reference

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eIF4G: a multipurpose ribosome adapter?

27 September 2017

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An internal open reading frame triggers nonsense-mediated decay of the yeast SPT10 mRNA.

27 September 2017

1 reference

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Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint

30 May 2018

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Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme

30 May 2018

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Genetic engineering of Schizosaccharomyces pombe: a system for gene disruption and replacement using the ura4 gene as a selectable marker

30 May 2018

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DNA sequence analysis of the ade6 gene of Schizosaccharomyces pombe. Wild-type and mutant alleles including the recombination host spot allele ade6-M26.

30 May 2018

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Analysis of mutations in the yeast mRNA decapping enzyme

30 May 2018

1 reference

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Nonsense suppressors partially revert the decrease of the mRNA level of a nonsense mutant allele in yeast

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/11073994

12 December 2020

A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/11073994

12 December 2020

The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay

1 reference

https://pubmed.ncbi.nlm.nih.gov/11073994

12 December 2020

Comparative genomics, genome cross-referencing and XREFdb

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https://pubmed.ncbi.nlm.nih.gov/11073994

12 December 2020

Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/11073994

12 December 2020

Thiamine-repressible expression vectors pREP and pRIP for fission yeast

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https://pubmed.ncbi.nlm.nih.gov/11073994

12 December 2020

The skipping of constitutive exons in vivo induced by nonsense mutations

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https://pubmed.ncbi.nlm.nih.gov/11073994

12 December 2020

mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11073994

12 December 2020

mRNA surveillance by the Caenorhabditis elegans smg genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11073994

12 December 2020

Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon

1 reference

https://pubmed.ncbi.nlm.nih.gov/11073994

12 December 2020