Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor (Q24316179)

GOA release 2020-03-11

antigen binding

1 reference

GOA release 2020-03-11

author name string

A E Corcoran

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A Riddell

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D Krooshoop

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A R Venkitaraman

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

4

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language of work or name

English

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publication date

26 February 1998

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published in

Nature

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volume

391

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issue

6670

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page(s)

904-7

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cites work

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The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver

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Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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RAG-1-deficient mice have no mature B and T lymphocytes

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Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

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Development of the primary antibody repertoire

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Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

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Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

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Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells

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Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

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Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis

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Regulation of the assembly and expression of variable-region genes

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Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

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Failure of B-cell differentiation in mice lacking the transcription factor EBF.

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Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line

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Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

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Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion

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Enumeration and characterization of DJH structures in mouse fetal liver

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7 January 2021

VH gene family utilization in colonies derived from B and pre-B cells detected by the RNA colony blot assay

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Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

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Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor

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The status of Ig loci rearrangements in single cells from different stages of B cell development

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7 January 2021