Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB (Q24290138)

protein homodimerization activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Transcription factor 12

1 reference

Molecular and Cellular Biology

GOA release 2020-03-11

author name string

R J Barndt

series ordinal

1

0 references

M Dai

series ordinal

2

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Y Zhuang

series ordinal

3

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language of work or name

English

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publication date

September 2000

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published in

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volume

20

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issue

18

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page(s)

6677-85

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cites work

B-cell-specific DNA binding by an E47 homodimer

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Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

19 March 2017

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A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

19 March 2017

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The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

19 March 2017

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Profound block in thymocyte development in mice lacking p56lck

19 March 2017

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HEB, a Helix-Loop-Helix Protein Related to E2A and ITF2 That Can Modulate the DNA-Binding Ability of Myogenic Regulatory Factors

19 March 2017

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Essential role of LAT in T cell development

19 March 2017

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Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1

19 March 2017

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E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

19 March 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

The helix-loop-helix gene E2A is required for B cell formation

19 March 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

The protein Id: a negative regulator of helix-loop-helix DNA binding proteins

19 March 2017

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Transcription factor GATA-3 is required for development of the T-cell lineage

19 March 2017

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The Ikaros gene is required for the development of all lymphoid lineages

19 March 2017

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Definition of a T-cell receptor beta gene core enhancer of V(D)J recombination by transgenic mapping.

19 March 2017

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Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice

27 September 2017

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Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12.

27 September 2017

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Functional replacement of the mouse E2A gene with a human HEB cDNA.

27 September 2017

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EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

Developmental regulation of VDJ recombination by the core fragment of the T cell receptor alpha enhancer

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

E47 activates the Ig-heavy chain and TdT loci in non-B cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

Helix-loo-helix proteins in the regulation of immunoglobulin gene transcription

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

T-cell specific rearrangement of T-cell receptor beta transgenes in mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

Early alpha beta T cell development in the thymus of normal and genetically altered mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

Overexpression of the Helix-Loop-Helix protein Id2 blocks T cell development at multiple stages.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

Both E12 and E47 allow commitment to the B cell lineage

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

Tissue-specific RNA splicing generates an ankyrin-like domain that affects the dimerization and DNA-binding properties of a bHLH protein

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86175

Constitutive expression of the Id1 gene impairs mouse B cell development

29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/10958665

12 December 2020

An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures

1 reference

https://pubmed.ncbi.nlm.nih.gov/10958665

12 December 2020

An HMG-box-containing T-cell factor required for thymocyte differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10958665

12 December 2020

T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10958665

12 December 2020