GATA binding protein 3 (Q21497809)

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mammalian protein found in Mus musculus
  • trans-acting T-cell-specific transcription factor GATA-3
  • Gata3
  • GATA-binding factor 3
edit
Language Label Description Also known as
English
GATA binding protein 3
mammalian protein found in Mus musculus
  • trans-acting T-cell-specific transcription factor GATA-3
  • Gata3
  • GATA-binding factor 3

Statements

molecular function
protein binding
determination method
IPI
6 references
retrieved
14 February 2019
stated in
Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet
GOA
curator
UniProt
UniProt protein ID
P23772
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IPI
retrieved
14 February 2019
stated in
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
GOA
curator
UniProt
UniProt protein ID
P23772
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IPI
retrieved
14 February 2019
stated in
GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2
GOA
curator
UniProt
UniProt protein ID
P23772
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IPI
retrieved
14 February 2019
stated in
c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation
GOA
curator
UniProt
UniProt protein ID
P23772
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IPI
retrieved
14 February 2019
stated in
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IPI
retrieved
14 February 2019
stated in
Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IPI
transcription coactivator activity
determination method
IBA
IDA
IEA
ISO
ISS
5 references
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P23772
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772
determination method
ISS
retrieved
1 January 2018
stated in
Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772
determination method
ISO
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772
determination method
IEA
retrieved
1 January 2018
stated in
Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772
determination method
IBA
cell component
nucleus
determination method
IDA
IEA
ISO
10 references
retrieved
21 June 2018
stated in
Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772
determination method
ISO
retrieved
21 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P23772
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772
determination method
IEA
retrieved
21 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772
determination method
IEA
retrieved
21 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772
determination method
IEA
retrieved
21 June 2018
stated in
TCR-dependent translational control of GATA-3 enhances Th2 differentiation
GOA
curator
UniProt
UniProt protein ID
P23772
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
21 June 2018
stated in
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
GOA
curator
UniProt
UniProt protein ID
P23772
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
21 June 2018
stated in
GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
21 June 2018
stated in
GATA-3: an unexpected regulator of cell lineage determination in skin
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
21 June 2018
stated in
GATA3 is downregulated during hair cell differentiation in the mouse cochlea
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
21 June 2018
stated in
Gata3 is a critical regulator of cochlear wiring
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23772&geneProductId=UniProtKB:P23772
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
ISO
11 references
retrieved
14 February 2019
stated in
Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P23772
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IEA
retrieved
14 February 2019
stated in
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
GOA
curator
UniProt
UniProt protein ID
P23772
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
14 February 2019
stated in
TCR-dependent translational control of GATA-3 enhances Th2 differentiation
GOA
curator
UniProt
UniProt protein ID
P23772
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
14 February 2019
stated in
GATA3 is downregulated during hair cell differentiation in the mouse cochlea
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
14 February 2019
stated in
GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
14 February 2019
stated in
Gata3 is a critical regulator of cochlear wiring
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
14 February 2019
stated in
GATA-3: an unexpected regulator of cell lineage determination in skin
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IBA
biological process
regulation of transcription by RNA polymerase II
determination method
IDA
IGI
IMP
5 references
retrieved
14 February 2019
stated in
Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IMP
retrieved
14 February 2019
stated in
Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IMP
retrieved
14 February 2019
stated in
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IGI
retrieved
14 February 2019
stated in
Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
14 February 2019
stated in
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA
positive regulation of transcription, DNA-templated
determination method
IDA
IEA
IMP
ISO
6 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
ISO
retrieved
14 February 2019
stated in
Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction
GOA
curator
UniProt
UniProt protein ID
P23772
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IMP
retrieved
14 February 2019
stated in
Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney
GOA
curator
UniProt
UniProt protein ID
P23772
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IEA
retrieved
14 February 2019
stated in
GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2
GOA
curator
UniProt
UniProt protein ID
P23772
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
14 February 2019
stated in
Identification and characterization of SKAT-2, a novel Th2-specific zinc finger gene
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA
positive regulation of transcription by RNA polymerase II
determination method
IDA
IGI
IEA
IMP
ISO
12 references
retrieved
14 February 2019
stated in
Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
ISO
retrieved
14 February 2019
stated in
GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IMP
retrieved
14 February 2019
stated in
ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1)
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IMP
retrieved
14 February 2019
stated in
The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IMP
retrieved
14 February 2019
stated in
TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IGI
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IEA
retrieved
14 February 2019
stated in
Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
14 February 2019
stated in
Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
14 February 2019
stated in
Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
14 February 2019
stated in
Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
14 February 2019
stated in
GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA
retrieved
14 February 2019
stated in
Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23772
determination method
IDA

Identifiers

 
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