Role of the CDK inhibitor p27 (Kip1) in mammary development and carcinogenesis: insights from knockout mice (Q35745139)

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scientific article published on January 2004

Language	Label	Description	Also known as
English	Role of the CDK inhibitor p27 (Kip1) in mammary development and carcinogenesis: insights from knockout mice	scientific article published on January 2004

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

1 reference

Europe PubMed Central

Role of the CDK inhibitor p27 (Kip1) in mammary development and carcinogenesis: insights from knockout mice (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

0 references

1 reference

based on heuristic

inferred from title

Christopher J Ormandy

3

object named as

Christopher J Ormandy

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

author name string

Elizabeth A Musgrove

1

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Elizabeth A Davison

2

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

publication date

1 January 2004

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Journal of Mammary Gland Biology and Neoplasia

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Europe PubMed Central

PubMed publication ID

10 August 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

55-66

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of Neu-induced mammary tumor growth in cyclin D1 deficient mice is compensated for by cyclin E.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the cdk inhibitor p27 and its deregulation in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brca1 inactivation induces p27(Kip1)-dependent cell cycle arrest and delayed development in the mouse mammary gland.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer susceptibility and the functions of BRCA1 and BRCA2

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the phosphatidylinositol 3-kinase signaling pathway in anchorage-independent growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibin and p27 interact to regulate gonadal tumorigenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Germline BRCA1/2 mutations and p27(Kip1) protein levels independently predict outcome after breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired mammary gland development in Cyl-1(-/-) mice during pregnancy and lactation is epithelial cell autonomous

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New functional activities for the p21 family of CDK inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRCA1 expression status in relation to DNA methylation of the BRCA1 promoter region in sporadic breast cancers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ErbB-2-induced mammary tumor growth: the role of cyclin D1 and p27Kip1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation of p27 protein expression with HER-2/neu expression in breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ErbB receptors and their role in cancer progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional microarray analysis of mammary organogenesis reveals a developmental role in adaptive thermogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p27 deregulation in breast cancer: prognostic significance and implications for therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p27(Kip1) induces quiescence and growth factor insensitivity in tamoxifen-treated breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during the granulosa->luteal transition

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

To cycle or not to cycle: a critical decision in cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammary tumor formation in p53- and BRCA1-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Untangling the ErbB signalling network

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p27Kip1 Inhibition of GRB2-SOS Formation Can Regulate Ras Activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of cyclin-dependent kinase inactivation by progestins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific protection against breast cancers by cyclin D1 ablation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased immunoreactivity for p27 protein in patients with early-stage breast carcinoma is correlated with HER-2/neu overexpression and with benefit from one course of perioperative chemotherapy in patients with negative lymph node status: results

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRCA-associated breast cancer: absence of a characteristic immunophenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cyclin-dependent kinase inhibitor p27 (Kip1) regulates both DNA synthesis and apoptosis in mammary epithelium but is not required for its functional development during pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRCA1 transactivates the cyclin-dependent kinase inhibitor p27(Kip1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p27Kip1 and p21Cip1 Are Not Required for the Formation of Active D Cyclin-cdk4 Complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted inactivation of p27kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a Western-style high-risk diet.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of cyclin D2 and p27(Kip1) in cyclin D2 transgenic mouse mammary gland during development

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ErbBs in mammary development

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRCA1-associated tumorigenesis: what have we learned from knockout mice?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High p27Kip1 Expression Predicts Superior Relapse-Free and Overall Survival for Premenopausal Women With Early-Stage Breast Cancer Receiving Adjuvant Treatment With Tamoxifen Plus Goserelin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15082918

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/B:JOMG.0000023588.55733.84

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

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