Anti-epileptic activity of group II metabotropic glutamate receptor agonists (--)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (--)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795). (Q34083484)

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Language	Label	Description	Also known as
English	Anti-epileptic activity of group II metabotropic glutamate receptor agonists (--)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (--)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795).	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

30 July 2017

Anti-epileptic activity of group II metabotropic glutamate receptor agonists (--)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (--)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795). (English)

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30 July 2017

author name string

R X Moldrich

1

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Europe PubMed Central

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30 July 2017

M Jeffrey

2

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Europe PubMed Central

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30 July 2017

A Talebi

3

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Europe PubMed Central

PubMed publication ID

30 July 2017

P M Beart

4

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Europe PubMed Central

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30 July 2017

A G Chapman

5

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Europe PubMed Central

PubMed publication ID

30 July 2017

B S Meldrum

6

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Europe PubMed Central

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30 July 2017

publication date

1 July 2001

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30 July 2017

Neuropharmacology

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30 July 2017

41

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30 July 2017

1

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30 July 2017

8-18

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30 July 2017

Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV).

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Specific group II metabotropic glutamate receptor activation inhibits the development of kindled epilepsy in rats

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LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia

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beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain

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Inhibition of the interaction of G protein G(o) with calcium channels by the calcium channel beta‐subunit in rat neurones

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Regulation of neurotransmitter release by metabotropic glutamate receptors

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Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).

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Pharmacology and functions of metabotropic glutamate receptors

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The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice

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Activity-dependent presynaptic autoinhibition by group II metabotropic glutamate receptors at the perforant path inputs to the dentate gyrus and CA1.

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Neuroprotection by metabotropic glutamate receptor glutamate receptor agonists: LY354740, LY379268 and LY389795.

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Roles of group II metabotropic glutamate receptors in modulation of seizure activity.

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Group II selective metabotropic glutamate receptor agonists and local cerebral glucose use in the rat

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Decreased (45)Ca(2)(+) uptake in P/Q-type calcium channels in homozygous lethargic (Cacnb4lh) mice is associated with increased beta3 and decreased beta4 calcium channel subunit mRNA expression

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Glutamate receptors and transporters in genetic and acquired models of epilepsy

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Anticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for group II metabotropic glutamate receptors against intraventricular kainate in the rat.

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The mGlu(2/3) agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti- and proconvulsant in DBA/2 mice

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7 January 2021

Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxioly

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The metabotropic glutamate receptors: structure and functions

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Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4- dicarboxylate

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The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors

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10.1016/S0028-3908(01)00044-2

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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