Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70. (Q41909802)

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scientific article published on November 1997

Language	Label	Description	Also known as
English	Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.	scientific article published on November 1997

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70. (English)

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

author name string

C R Calvo

1

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

D Amsen

2

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

A M Kruisbeek

3

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

publication date

1 November 1997

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Journal of Experimental Medicine

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

186

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

10

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

1645-1653

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion

1 reference

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Is CTLA-4 a master switch for peripheral T cell tolerance?

1 reference

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Costimulation and autoimmunity

1 reference

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The emerging field of receptor-mediated inhibitory signaling: SHP or SHIP?

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Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways

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Mitogen-activated protein kinase cascades and regulation of gene expression

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Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes

1 reference

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T cell antigen receptor signal transduction pathways

1 reference

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CD28/B7 system of T cell costimulation

1 reference

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5 June 2018

CTLA-4 ligation blocks CD28-dependent T cell activation

1 reference

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5 June 2018

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

1 reference

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Upstream-downstream: CD28 cosignaling pathways and T cell function

1 reference

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5 June 2018

Regulation of CTLA-4 expression during T cell activation

1 reference

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Signaling through CD28/CTLA-4 family receptors: puzzling participation of phosphatidylinositol-3 kinase

1 reference

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Die and let live: eliminating dangerous lymphocytes

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Enhancement of antitumor immunity by CTLA-4 blockade

1 reference

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5 June 2018

Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase

1 reference

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5 June 2018

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1 reference

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5 June 2018

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1 reference

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5 June 2018

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1 reference

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5 June 2018

T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

1 reference

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5 June 2018

Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes

1 reference

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5 June 2018

Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.

1 reference

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5 June 2018

Characterization of CTLA-4 structure and expression on human T cells.

1 reference

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The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

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p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes.

1 reference

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5 June 2018

Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation

1 reference

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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

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Raf-1 is required for T cell IL2 production.

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5 June 2018

JNK is involved in signal integration during costimulation of T lymphocytes.

1 reference

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The stress-activated protein kinase subfamily of c-Jun kinases

1 reference

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1 reference

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Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors

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CTLA-4 can function as a negative regulator of T cell activation

1 reference

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Transcriptional regulation by extracellular signals: mechanisms and specificity

1 reference

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CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells

1 reference

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Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function

1 reference

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Constitutive Tyrosine Phosphorylation of the T-Cell Receptor (TCR) ζ Subunit: Regulation of TCR-Associated Protein Tyrosine Kinase Activity by TCR ζ

1 reference

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ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

1 reference

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1 reference

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Induction of apoptosis in mature T cells by tumour necrosis factor

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Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail

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CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

1 reference

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The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

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Contingent genetic regulatory events in T lymphocyte activation

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1 reference

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Nuclear factor of activated T cells contains Fos and Jun.

1 reference

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1 reference

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p21ras mediates control of IL-2 gene promoter function in T cell activation.

1 reference

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ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

1 reference

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Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes

1 reference

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Identification and distribution of the costimulatory receptor CD28 in the mouse

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Antigen receptor tail clue.

1 reference

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Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70

1 reference

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18 August 2018

Identifiers

10.1084/JEM.186.10.1645

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

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