Interleukin 6 (Q412889)

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mammalian protein found in Homo sapiens
  • BSF-2
  • IL6
  • interleukin-6
  • interferon beta-2
  • interleukin BSF-2
  • CDF
  • CTL differentiation factor
  • hybridoma growth factor
  • B-cell differentiation factor
  • IFN-beta-2
  • B-cell stimulatory factor 2
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Language Label Description Also known as
English
Interleukin 6
mammalian protein found in Homo sapiens
  • BSF-2
  • IL6
  • interleukin-6
  • interferon beta-2
  • interleukin BSF-2
  • CDF
  • CTL differentiation factor
  • hybridoma growth factor
  • B-cell differentiation factor
  • IFN-beta-2
  • B-cell stimulatory factor 2

Statements

molecular function
cytokine activity
determination method or standard
NAS
IDA
ISS
IEA
6 references
retrieved
27 March 2018
stated in
Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
determination method or standard
NAS
retrieved
27 March 2018
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
determination method or standard
ISS
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P05231
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
determination method or standard
IEA
retrieved
27 March 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
determination method or standard
IEA
retrieved
27 March 2018
stated in
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
determination method or standard
IDA
retrieved
27 March 2018
stated in
Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
determination method or standard
IDA
protein binding
determination method or standard
IPI
5 references
retrieved
27 March 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
determination method or standard
IPI
retrieved
27 March 2018
stated in
Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
determination method or standard
IPI
retrieved
27 March 2018
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
determination method or standard
IPI
retrieved
27 March 2018
stated in
Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
determination method or standard
IPI
retrieved
27 March 2018
stated in
Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
determination method or standard
IPI
cell component
biological process
positive regulation of receptor signaling pathway via JAK-STAT
determination method or standard
IC
IDA
4 references
retrieved
27 March 2018
stated in
Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
determination method or standard
IDA
retrieved
27 March 2018
stated in
JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
determination method or standard
IDA
retrieved
27 March 2018
stated in
Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
determination method or standard
IDA
retrieved
27 March 2018
stated in
Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
determination method or standard
IC

Identifiers

BNCF Thesaurus ID
73989
0 references
 
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