TC-1734: an orally active neuronal nicotinic acetylcholine receptor modulator with antidepressant, neuroprotective and long-lasting cognitive effects. (Q34324800)

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English	TC-1734: an orally active neuronal nicotinic acetylcholine receptor modulator with antidepressant, neuroprotective and long-lasting cognitive effects.	scientific article

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scholarly article

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29 December 2019

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TC-1734: an orally active neuronal nicotinic acetylcholine receptor modulator with antidepressant, neuroprotective and long-lasting cognitive effects (English)

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29 December 2019

author name string

Gregory J Gatto

1

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29 December 2019

G Andrees Bohme

2

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29 December 2019

William S Caldwell

3

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29 December 2019

Sharon R Letchworth

4

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29 December 2019

Vincent M Traina

5

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29 December 2019

M Carmen Obinu

6

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29 December 2019

Michel Laville

7

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29 December 2019

Michel Reibaud

8

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29 December 2019

Laurent Pradier

9

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29 December 2019

Geoffrey Dunbar

10

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29 December 2019

Merouane Bencherif

11

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29 December 2019

publication date

1 January 2004

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29 December 2019

CNS Neuroscience & Therapeutics

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29 December 2019

10

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29 December 2019

2

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29 December 2019

147-166

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29 December 2019

Intravenous nicotine in a patient with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2004.TB00010.X

21 January 2018

Multiple central nervous system targets for eliciting beneficial effects on memory and cognition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic nicotinic stimulation and blockade effects on working memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIB-1553A, (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride, a subtype-selective ligand for nicotinic acetylcholine receptors with putative cognitive-enhancing properties: effects on working and reference memory performances in a

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of non-alpha7 nicotinic receptors partially protects dopaminergic neurons from 1-methyl-4-phenylpyridinium-induced toxicity in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-selective stimulation of nicotinic receptors by TC-1734 enhances ACh transmission from frontoparietal cortex and memory in rodents

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting neuronal nicotinic receptors: a path to new therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistence of chronic nicotine-induced cognitive facilitation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of nicotine on attention, information processing, and short-term memory in patients with dementia of the Alzheimer type

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-nicotine protects against systemic kainic acid-induced excitotoxic effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of local and repeated systemic administration of (-)nicotine on extracellular levels of acetylcholine, norepinephrine, dopamine, and serotonin in rat cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic nicotine treatment counteracts dopamine D2 receptor upregulation induced by a partial meso-diencephalic hemitransection in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine protects cultured striatal neurones against N-methyl-D-aspartate receptor-mediated neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine enhances the learning and memory of aged rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine-induced protection against glutamate cytotoxicity. Nicotinic cholinergic receptor-mediated inhibition of nitric oxide formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine rescues PC12 cells from death induced by nerve growth factor deprivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine inhibits amyloid formation by the beta-peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology of (-)-nicotine and novel cholinergic channel modulators.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine protects against the dexamethasone potentiation of kainic acid-induced neurotoxicity in cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A microdialysis study of the effects of the nicotinic agonist RJR-2403 on cortical release of acetylcholine and biogenic amines

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GTS-21, a Nicotinic Agonist, Protects against Neocortical Neuronal Cell Loss Induced by the Nucleus Basalis Magnocellularis Lesion in Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via alpha7-neuronal receptors and neuronal CNS receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15179444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1527-3458.2004.TB00010.X

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30 July 2022

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30 July 2022

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PMC publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15179444%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

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30 July 2022

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