Reaching a genetic and molecular understanding of skeletal development (Q34611297)

3 August 2017

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title

Reaching a genetic and molecular understanding of skeletal development (English)

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3 August 2017

Erwin F Wagner

2

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author name string

Gerard Karsenty

series ordinal

1

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3 August 2017

language of work or name

English

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publication date

1 April 2002

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3 August 2017

number of pages

18

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inferred from page(s)

published in

Developmental Cell

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3 August 2017

volume

2

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3 August 2017

issue

4

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3 August 2017

page(s)

389-406

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Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors

3 August 2017

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Regulation of osteoclast formation and function

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Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL.

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Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones

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Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype

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Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton

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7 January 2021

Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues.

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7 January 2021

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

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7 January 2021

Involvement of Wnt-5a in chondrogenic pattern formation in the chick limb bud.

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7 January 2021

Regulation of chondrocyte differentiation by Cbfa1

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7 January 2021

Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis

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7 January 2021

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

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7 January 2021

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7 January 2021

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

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7 January 2021

PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth

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Transforming growth factor-beta regulation of bone morphogenetic protein-1/procollagen C-proteinase and related proteins in fibrogenic cells and keratinocytes

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7 January 2021

A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene

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7 January 2021

Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures

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7 January 2021

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

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The microphthalmia transcription factor regulates expression of the tartrate-resistant acid phosphatase gene during terminal differentiation of osteoclasts

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Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway

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Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

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Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

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SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse

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Fibroblast growth factors

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Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

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7 January 2021

Fra-1 potentiates osteoclastic differentiation in osteoclast-macrophage precursor cell lines

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7 January 2021

Mutations in CDMP1 cause autosomal dominant brachydactyly type C

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7 January 2021

Bone morphogenetic proteins: an unconventional approach to isolation of first mammalian morphogens.

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Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice

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7 January 2021

Atrial natriuretic factor and related peptide hormones

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7 January 2021

Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

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Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development.

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Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis.

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7 January 2021

FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway

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7 January 2021

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

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7 January 2021

A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia

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7 January 2021

Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide

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7 January 2021

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

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7 January 2021

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

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7 January 2021

The transcription factors L-Sox5 and Sox6 are essential for cartilage formation

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7 January 2021

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

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7 January 2021

Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily

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7 January 2021

GDF5 coordinates bone and joint formation during digit development

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7 January 2021

Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism

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7 January 2021

Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide

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7 January 2021

Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families

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7 January 2021

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

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7 January 2021

Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice

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7 January 2021

Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3.

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7 January 2021

Bone resorption by osteoclasts

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7 January 2021

Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1

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7 January 2021

A human chondrodysplasia due to a mutation in a TGF-beta superfamily member

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7 January 2021

Osteopetrosis in mice lacking haematopoietic transcription factor PU.1.

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7 January 2021

Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function

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7 January 2021

Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes

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7 January 2021

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein

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7 January 2021

MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes

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7 January 2021

Genetic control of skeletal development

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7 January 2021

Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9

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Recombinant human bone morphogenetic protein induces bone formation

1 reference

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Bone and haematopoietic defects in mice lacking c-fos

1 reference

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7 January 2021

Chondrocytes as a specific target of ectopic Fos expression in early development

1 reference

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7 January 2021

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

1 reference

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Linkage of M-CSF signaling to Mitf, TFE3, and the osteoclast defect in Mitf(mi/mi) mice

1 reference

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7 January 2021

The status of Wnt signalling regulates neural and epidermal fates in the chick embryo

1 reference

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7 January 2021

TRANCE is a TNF family member that regulates dendritic cell and osteoclast function

1 reference

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7 January 2021

The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor

1 reference

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7 January 2021

TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells

1 reference

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TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage

1 reference

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7 January 2021

Negative regulation of BMP/Smad signaling by Tob in osteoblasts

1 reference

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7 January 2021

Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2.

1 reference

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Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation

1 reference

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7 January 2021

Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage

1 reference

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7 January 2021

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Identifiers

DOI

1 reference

3 August 2017

1 reference