CD80 molecule (Q5009843)

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mammalian protein found in Homo sapiens

B7
T-lymphocyte activation antigen CD80
costimulatory factor CD80
B-lymphocyte activation antigen B7
CD80
costimulatory molecule variant IgV-CD80
CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
CTLA-4 counter-receptor B7.1
activation B7-1 antigen
BB1

Language	Label	Description	Also known as
English	CD80 molecule	mammalian protein found in Homo sapiens	B7 T-lymphocyte activation antigen CD80 costimulatory factor CD80 B-lymphocyte activation antigen B7 CD80 costimulatory molecule variant IgV-CD80 CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) CTLA-4 counter-receptor B7.1 activation B7-1 antigen BB1

Statements

1 reference

13 November 2019

UniProt protein ID

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33681

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33681

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

coreceptor activity

determination method or standard

1 reference

31 October 2017

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

virus receptor activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

protein binding

determination method or standard

6 references

8 April 2019

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

8 April 2019

Structure and Interactions of the Human Programmed Cell Death 1 Receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

8 April 2019

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

8 April 2019

A secreted protein microarray platform for extracellular protein interaction discovery

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

8 April 2019

PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

8 April 2019

Interaction of human PD-L1 and B7-1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

determination method or standard

external side of plasma membrane

determination method or standard

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

integral component of membrane

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

protein complex involved in cell adhesion

determination method or standard

1 reference

8 April 2019

Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

external side of plasma membrane

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

determination method or standard

integral component of membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

biological process

intracellular signal transduction

determination method or standard

1 reference

8 April 2019

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of interleukin-2 production

determination method or standard

1 reference

8 April 2019

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of alpha-beta T cell proliferation

determination method or standard

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

cell-cell signaling

determination method or standard

1 reference

31 October 2017

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of signal transduction

determination method or standard

1 reference

8 April 2019

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

cellular response to lipopolysaccharide

determination method or standard

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of T-helper 1 cell differentiation

determination method or standard

1 reference

8 April 2019

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

viral entry into host cell

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of T cell proliferation

determination method or standard

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of peptidyl-tyrosine phosphorylation

determination method or standard

1 reference

8 April 2019

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

1 reference

8 April 2019

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of granulocyte macrophage colony-stimulating factor production

determination method or standard

1 reference

8 April 2019

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

T cell activation

determination method or standard

1 reference

31 October 2017

CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

phosphatidylinositol phosphate biosynthetic process

determination method or standard

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33681&geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of protein kinase B signaling

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

immune response

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

signal transduction

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

cell surface receptor signaling pathway

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

cytokine-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

T cell costimulation

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

positive regulation of T cell proliferation

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

negative regulation of T cell proliferation

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

cellular response to lipopolysaccharide

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33681

determination method or standard

http://purl.uniprot.org/uniprot/P33681

1 reference

Identifiers.org

CD80-like, immunoglobulin C2-set

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33681

immunoglobulin V-set domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33681

immunoglobulin-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33681

immunoglobulin subtype

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33681

CD80, IgC-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33681

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

22 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000264246

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000264246

ENSP00000373165

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373165

ENSP00000418364

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000418364

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(9 entries)

arwiki كتلة التمايز 80
cswiki CD80
dewiki B7-1
enwiki CD80
fawiki CD80
plwiki CD80
trwiki CD80
ukwiki CD80
urwiki سیڈی اسی

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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