'Evolutionary medicine' perspectives on Alzheimer's Disease: Review and new directions (Q57174334)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30059789%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

title

'Evolutionary medicine' perspectives on Alzheimer's Disease: Review and new directions (English)

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15 April 2020

1 reference

1

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15 April 2020

author name string

Molly Fox

series ordinal

1

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language of work or name

English

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publication date

27 July 2018

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15 April 2020

published in

Ageing Research Reviews

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15 April 2020

volume

47

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15 April 2020

page(s)

140-148

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Unusual sex hormone patterns among desert-dwelling hunter-gatherers

15 April 2020

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Humans, lipids and evolution

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The normal menopause transition

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Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells

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Hypothesis: Alzheimer's disease is a phylogenetic disease

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The genetics of Alzheimer's disease: a review and a discussion of the implications

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Stone agers in the fast lane: chronic degenerative diseases in evolutionary perspective

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Chronic degenerative diseases in evolutionary perspective

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Menarche, pregnancy, birth spacing and menopause among the Agta women foragers of Cagayan province, Luzon, the Philippines

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The genetical evolution of social behaviour. I

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Alzheimer's disease: a study of epidemiological aspects.

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Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans.

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High frequency of the apo epsilon 4 allele in Khoi San from South Africa

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12 December 2020

Women's reproductive cancers in evolutionary context

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Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury

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Alterations in glucose metabolism in patients with Alzheimer's disease.

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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12 December 2020

Antioxidant potential of specific estrogens on lipid peroxidation

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12 December 2020

Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study

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12 December 2020

Structure-antioxidant activity relationships of flavonoids and phenolic acids

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12 December 2020

APP peptides stimulate lymphocyte proliferation in normals, but not in patients with Alzheimer's disease

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12 December 2020

ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative.

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12 December 2020

Herpes simplex virus type 1 in brain and risk of Alzheimer's disease

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12 December 2020

Interactions of the Alzheimer beta amyloid fragment (25-35) with peripheral blood dendritic cells.

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12 December 2020

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

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12 December 2020

Apolipoprotein E phenotypes and cardiovascular responses to experimentally induced mental stress in adolescent boys

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12 December 2020

Apolipoprotein E polymorphism in elderly east Africans

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12 December 2020

Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures

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12 December 2020

Genetic association of apolipoprotein E with age-related macular degeneration

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12 December 2020

Physical activity, energy expenditure and fitness: an evolutionary perspective

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12 December 2020

Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy

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12 December 2020

TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer's disease.

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms

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12 December 2020

Immunization with beta-amyloid: could T-cell activation have a harmful effect?

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a 'thrifty' allele?

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12 December 2020

Archaeology. The cradle of agriculture

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12 December 2020

Antiinflammatory effects of estrogen on microglial activation

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Apolipoprotein E polymorphism and serum concentration in Alzheimer's disease in nine European centres: the ApoEurope study. ApoEurope group

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Alzheimer's disease and some speculations about the evolution of its modifiers.

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12 December 2020

How is Darwinian medicine useful?

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12 December 2020

Life span and synapses: will there be a primary senile dementia?

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Environmental pesticide exposure as a risk factor for Alzheimer's disease: a case-control study

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Estrogen induces a rapid secretion of amyloid beta precursor protein via the mitogen-activated protein kinase pathway

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Estrogen regulates bcl-x expression in rat hippocampus

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Hominid behaviour and the earliest occupation of Europe: an exploration

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

T-helper-1 and T-helper-2 responses in psychiatric disorders

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Evolutionary health promotion

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

The paradoxical nature of hunter-gatherer diets: meat-based, yet non-atherogenic

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Influence of the apolipoprotein E epsilon4 allele on human embryonic development.

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

The variability of female reproductive ageing

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

ApoE4: is it the absence of good or the presence of bad?

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

A Darwinian-evolutionary concept of age-related diseases

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Neurodegenerative diseases and exposure to pesticides in the elderly.

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

The common polymorphism of apolipoprotein E: geographical aspects and new pathophysiological relations

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Genetic and environmental epidemiology of Alzheimer's disease in arabs residing in Israel

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Apolipoprotein E polymorphisms and risk of malaria

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Modulation of memory by insulin and glucose: neuropsychological observations in Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Meat-adaptive genes and the evolution of slower aging in humans

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Recent decline in age at menarche: the Fels Longitudinal Study

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

APOE4 protects the cognitive development in children with heavy diarrhea burdens in Northeast Brazil

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Aluminium in Alzheimer's disease: are we still at a crossroad?

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Glycogen synthase kinase 3beta links neuroprotection by 17beta-estradiol to key Alzheimer processes

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective?

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

What is aging? What is its role in Alzheimer's disease? What can we do about it?

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

APOE epsilon4 is not associated with Alzheimer's disease in elderly Nigerians

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

[Alzheimer's disease and brain evolution: is Alzheimer's disease an example of antagonistic pleiotropy?].

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12 December 2020

Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin.

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Relationship between Helicobacter pylori infection and Alzheimer disease.

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

FREQUENCY-DEPENDENT SELECTION AT THE ESTERASE 6 LOCUS IN Drosophila melanogaster

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease.

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

The association between apolipoprotein E and multiple sclerosis

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Involvement of environmental mercury and lead in the etiology of neurodegenerative diseases

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Genetic risk profiles for Alzheimer's disease: integration of APOE genotype and variants that up-regulate inflammation.

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Therapy Insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Apolipoprotein E4 genotype increases the risk of postoperative cognitive dysfunction in patients undergoing coronary artery bypass graft surgery.

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Neuropsychological and neuroimaging changes in preclinical Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

APOE distribution in world populations with new data from India and the UK

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best?

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

ApoE genotype, cardiovascular risk and responsiveness to dietary fat manipulation

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

The hygiene hypothesis and the increasing prevalence of chronic inflammatory disorders

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Estradiol in vivo regulation of brain mitochondrial proteome.

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Impact of apoE genotype on oxidative stress, inflammation and disease risk

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression.

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

A comparative study to screen dementia and APOE genotypes in an ageing East African population.

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Osteoporosis: an evolutionary perspective

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Review series on helminths, immune modulation and the hygiene hypothesis: the broader implications of the hygiene hypothesis

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Alzheimer's disease and natural cognitive aging may represent adaptive metabolism reduction programs.

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Pooled energy budget and human life history

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Forecasting the global burden of Alzheimer’s disease

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Infections and autoimmunity--friends or foes?

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Air pollution: mechanisms of neuroinflammation and CNS disease

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Life expectancy in Alzheimer's disease (AD).

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Alzheimer's disease is type 3 diabetes-evidence reviewed

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Evolution in health and medicine Sackler colloquium: Evolutionary perspectives on health and medicine.

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: darwinian medicine and the 'hygiene' or 'old friends' hypothesis

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Colloquium paper: how grandmother effects plus individual variation in frailty shape fertility and mortality: guidance from human-chimpanzee comparisons

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Drugs for Alzheimer's disease: are they effective?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Technology, diet, and the burden of chronic disease

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Inflammatory gene variants in the Tsimane, an indigenous Bolivian population with a high infectious load

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Effects of BRCA1 and BRCA2 mutations on female fertility

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Impact of chronic Helicobacter pylori infection on Alzheimer's disease: preliminary results

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Some evolutionary perspectives on Alzheimer's disease pathogenesis and pathology

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Immune profiling of Alzheimer patients

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Hunter-gatherer energetics and human obesity

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Alzheimer's disease: the downside of a highly evolved parietal lobe?

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

The case for soluble Aβ oligomers as a drug target in Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Environmental toxins and Parkinson's disease

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Cumulative estrogen exposure, number of menstrual cycles, and Alzheimer's risk in a cohort of British women

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Hygiene and the world distribution of Alzheimer's disease: Epidemiological evidence for a relationship between microbial environment and age-adjusted disease burden

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Heavy metals toxicity: effect of cadmium ions on amyloid beta protein 1-42. Possible implications for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

APOE genotype and neuroimaging markers of Alzheimer's disease: systematic review and meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Alzheimer's associated β-amyloid protein inhibits influenza A virus and modulates viral interactions with phagocytes.

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

β-Amyloid peptides display protective activity against the human Alzheimer's disease-associated herpes simplex virus-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Genomic divergence and brain evolution: How regulatory DNA influences development of the cerebral cortex

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden

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https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Does selection for short sleep duration explain human vulnerability to Alzheimer's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Coronary atherosclerosis in indigenous South American Tsimane: a cross-sectional cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Parkinson Disease: An Evolutionary Perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Effect of APOE ε4 allele on survival and fertility in an adverse environment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

The transition to modernity and chronic disease: mismatch and natural selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30059789

12 December 2020

10.1016/J.ARR.2018.07.008

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30059789%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30059789%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

PubMed publication ID

30059789

1 reference