ambrisentan (Q410789)

Ambrisentan (English)

18 November 2016

2 references

inferred from InChIKey

based on heuristic

inferred from InChI

chemical formula

C₂₂H₂₂N₂O₄

1 reference

Ambrisentan (English)

18 November 2016

canonical SMILES

CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C

1 reference

Ambrisentan (English)

18 November 2016

isomeric SMILES

CC1=CC(=NC(=N1)O[C@H](C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C

1 reference

Ambrisentan (English)

18 November 2016

defined daily dose

7.5 milligram

route of administration

oral administration

1 reference

https://www.whocc.no/atc_ddd_index/?code=C02KX02

active ingredient in

Volibris

1 reference

European Medicines Agency product number

EMEA/H/C/000839

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000839/human_med_001151.jsp

22 March 2017

1 reference

14 February 2018

medical condition treated

portal hypertension

1 reference

2 October 2018

systemic scleroderma

1 reference

2 October 2018

cor pulmonale

1 reference

Portopulmonary hypertension

2 October 2018

1 reference

2 October 2018

pulmonary hypertension

1 reference

connective tissue disease

2 October 2018

1 reference

chronic pulmonary heart disease

2 October 2018

1 reference

Food and Drug Administration

2 October 2018

pulmonary hypertension

start time

15 June 2007

approved by

1 reference

Inxight: Drugs Database

2 November 2018

https://drugs.ncats.io/drug/HW6NV07QEC

http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022081s029lbl.pdf

physically interacts with

Endothelin receptor type A

subject has role

antagonist

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Endothelin receptor type B

17 August 2016

subject has role

antagonist

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

legal status (medicine)

boxed warning

1 reference

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

Australian pregnancy category X

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)

pregnancy category

1 reference

imported from Wikimedia project

English Wikipedia

US pregnancy category X

1 reference

imported from Wikimedia project

English Wikipedia

LiverTox likelihood score

LiverTox toxicity likelihood category E

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Ambrisentan

last update

30 September 2017

subject has role

antihypertensive drug

1 reference

InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1

Medical Subject Headings

15 March 2018

Ambrisentan

0 references

Identifiers

InChI

1 reference

Ambrisentan (English)

18 November 2016

2 references

ChemIDplus

Ambrisentan (English)

5 May 2016

http://chem.sis.nlm.nih.gov/chemidplus/rn/177036-94-1

Ambrisentan (English)

18 November 2016

3 references

Ambrisentan (English)

5 May 2016

http://chem.sis.nlm.nih.gov/chemidplus/rn/177036-94-1

ambrisentan (English)

18 November 2016

https://commonchemistry.cas.org/detail?cas_rn=177036-94-1

9 April 2021

1 reference

ambrisentan (English)

3 October 2016

2 references

Ambrisentan (English)

18 November 2016

ChEBI ID

135949

mapping relation type

exact match

3 references

ChEBI release 2019-10-02

ChEBI release 2021-03-01

International Chemical Identifier

InChI

InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1

1 reference

AMBRISENTAN (English)

18 November 2016

2 references

inferred from InChIKey

splash10-0fb9-0519000000-334b60bcbe0d4e18e21c

1 reference

0 references

DSSTox substance ID

DTXSID4046282

2 references

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

DSSTOX compound identifier

0 references

0 references

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.184.855

27 December 2018

ECHA Substance Infocard ID

(+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid (English)

quotation

CAS no.: 177036-94-1 (English)

100.184.855

1 reference

ECHA Substance Infocard database

(+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid (English)

ECHA Substance Infocard ID

5 May 2016

100.184.855

ATC code

C02KX02

0 references

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

ambrisentan (English)

18 November 2016

1 reference

Medical Subject Headings

14 March 2018

1 reference

ambrisentan (English)

18 November 2016

DrugBank ID

DB06403

1 reference

3 references

Ambrisentan (English)

5 May 2016

http://chem.sis.nlm.nih.gov/chemidplus/rn/177036-94-1

ambrisentan (English)

18 November 2016

MedlinePlus drug identifier

a612023

0 references

PatientsLikeMe treatment ID

0 references

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

ambrisentan (English)

18 November 2016

0 references

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

UMLS CUI

C1176329

1 reference

ambrisentan (English)