Urokinase-type plasminogen activator and its receptor synergize to promote pathogenic proteolysis (Q34489359)

2 August 2017

title

Urokinase-type plasminogen activator and its receptor synergize to promote pathogenic proteolysis (English)

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2 August 2017

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H M Zhou

1

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2 August 2017

A Nichols

series ordinal

2

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2 August 2017

P Meda

series ordinal

3

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2 August 2017

J D Vassalli

series ordinal

4

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2 August 2017

language of work or name

English

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publication date

1 September 2000

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2 August 2017

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2 August 2017

volume

19

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2 August 2017

issue

17

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2 August 2017

page(s)

4817-4826

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Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling

2 August 2017

cites work

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Urokinase-type plasminogen activator binding to its receptor stimulates tumor cell migration by enhancing integrin-mediated signal transduction

6 July 2018

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Urokinase is a positive regulator of epidermal proliferation in vivo

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A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity.

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Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect

6 July 2018

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6 July 2018

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6 July 2018

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The receptor for urokinase-type plasminogen activator is expressed by keratinocytes at the leading edge during re-epithelialization of mouse skin wounds

6 July 2018

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6 July 2018

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Keratins (Kl6 and Kl7) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro

6 July 2018

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Interstitial collagenase is expressed by keratinocytes that are actively involved in reepithelialization in blistering skin disease

6 July 2018

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Sequences 5' of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development

6 July 2018

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Plasminogen is present in the basal layer of the epidermis

6 July 2018

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A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase

6 July 2018

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Limited cleavage of cellular fibronectin by plasminogen activator purified from transformed cells

6 July 2018

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The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases

6 July 2018

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The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type

6 July 2018

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Interaction of heparin with plasminogen activators and plasminogen: effects on the activation of plasminogen

6 July 2018

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Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin

6 July 2018

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Differential protease expression by cutaneous squamous and basal cell carcinomas

6 July 2018

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The plasminogen activator/plasmin system

6 July 2018

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Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor

6 July 2018

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Single-chain urokinase-type plasminogen activator does not possess measurable intrinsic amidolytic or plasminogen activator activities

6 July 2018

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Soluble fibrin preparations inhibit the reaction of plasmin with alpha 2-macroglobulin. Comparison with alpha 2-antiplasmin and leupeptin

6 July 2018

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Proteolytic processing of the 72,000-Da type IV collagenase by urokinase plasminogen activator

6 July 2018

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Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain

6 July 2018

1 reference

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Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor

6 July 2018

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Urokinase-catalyzed plasminogen activation at the monocyte/macrophage cell surface: a localized and regulated proteolytic system

6 July 2018

1 reference

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Plasminogen binding sites in normal human skin

6 July 2018

1 reference

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Extracellular proteolysis alters tooth development in transgenic mice expressing urokinase-type plasminogen activator in the enamel organ.

6 July 2018

1 reference

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The urokinase-type-plasminogen-activator receptor (CD87) is a pleiotropic molecule

27 October 2018

1 reference

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Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.

27 October 2018

1 reference

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uPA, uPAR, PAI-1: key intersection of proteolytic, adhesive and chemotactic highways?

27 October 2018

1 reference

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Binding and activation of plasminogen at the surface of human keratinocytes

27 October 2018

1 reference

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Correlation of proteolytic activities of organ cultured intact mouse skin with defined hair cycle stages.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=302082

Glycogen metabolism in psoriatic epidermis and in regenerating epidermis

27 October 2018

1 reference

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Concomitant secretion of prourokinase and of a plasminogen activator-specific inhibitor by cultured human monocytes-macrophages

27 October 2018

1 reference

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Tissue plasminogen activator in psoriasis

27 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

Migrating keratinocytes express urokinase-type plasminogen activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

Urokinase- and tissue-type plasminogen activators in keratinocytes during wound reepithelialization in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

Natural inhibitors of fibrinolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

Plasminogen activator in cultured human epidermal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

A cleaved form of the receptor for urokinase-type plasminogen activator in invasive transplanted human and murine tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

Physiological consequences of loss of plasminogen activator gene function in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

Demonstration of 72-kDa and 92-kDa forms of type IV collagenase in human skin: variable expression in various blistering diseases, induction during re-epithelialization, and decrease by topical glucocorticoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

Quantitative reverse zymography: analysis of picogram amounts of metalloproteinase inhibitors using gelatinase A and B reverse zymograms

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

The receptor for urokinase-type plasminogen activator is expressed during mouse spermatogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

Transforming growth factor-beta receptor type I and type II expression during murine hair follicle development and cycling

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

Pemphigus IgG induces expression of urokinase plasminogen activator receptor on the cell surface of cultured keratinocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

Regulation of gelatinase activity in mice with targeted inactivation of components of the plasminogen/plasmin system

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

Inhibition of mammary tumor cell adhesion, migration, and invasion by the selective synthetic urokinase inhibitor B428

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

The wound repair-associated keratins 6, 16, and 17. Insights into the role of intermediate filaments in specifying keratinocyte cytoarchitecture

1 reference

https://pubmed.ncbi.nlm.nih.gov/10970872

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/19.17.4817

1 reference

2 August 2017

1 reference

2 August 2017

1 reference